|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Problem based learning in midwifery-The students' perspective显示文摘 | Catherine JR McCourt C Sarah B | | 0，，01： | 1 |
| 3 | Problem based learning in midwifery-The students' perspective 显示文摘 | Catherine JR McCourt C Sarah B | 2008 | Nurse Education Today2008，28，1： | 1 |
| 4 | Animal Models of Bone Metastasis 显示文摘 | Thomas JR Sarah HT Bruce EL | 2003 | Cancer2003，97，3： | 1 |
| 5 | Relation between peripheral blood leukocyte counts and respiratory symptoms atopy lung function and airway responsiveness in adults 显示文摘 | Sarah AL Lan DP Stnger JR | 2001 | Chest2001，119，： | 1 |
| 6 | Engineering plants with increased disease resistence:what are we going to express显示文摘 | Sarah JG Paul JR | 2005 | Trend in Biotechnology2005，23，6： | 1 |
| 7 | Problem based learning in mid- wifery-The students'perspective显示文摘 | Catherine JR McCourt C Sarah B | 2008 | Nurse Education Today2008，28，1： | 1 |
| 8 | Problem based learning in midwifery-The students ~ perspective 显示文摘 | Catherine JR McCourt C Sarah B | 2008 | Nurse Education Today2008，28，1： | 1 |
| 9 | Paying for health insurance: the tradeoff between competition and adverse selection显示文摘 | Cutler DM Sarah JR | 1998 | Quarterly Journal of Economics1998，113，2： | 1 |
| 10 | Aging:impact upon local cerebral oxygenation and blood flow with acute isovolemic hemodilution显示文摘 | MIN L SARAH JR FRANKK etal | 2006 | J Neurosury Anesthesiol2006，18，2： | 1 |
| 11 | Regulatory T-cells and immune tolerance in pregnancy:a new target for infertility treatment 显示文摘 | Guerin LR Prins JR Sarah SA | 2009 | Human Reproduction Update2009，15，5： | 1 |
| 12 | Comparison of the extrusion rate of Crawford tubes显示文摘· AIM: To compare the outcomes of dacryocystorhinostomy(DCR) using traditional Crawford tubes(TCT) and Crawford tubes with suture(CTS) in the lumen.· METHODS: Retrospective case series consisting of patients who underwent DCR between 2008 and 2013.·RESULTS: A total of 61 DCRs were performed on 50 patients. Patients who underwent DCR using CTS had higher rates of prolapse compared to the TCT group(50% vs 9.4%; P =0.003). Stent removal occurred earlier in patients who received CTS(3.3mo vs 5.1mo; P =0.004). Success rates were equivalent between the two groups(75% vs 81.1%; P =0.684).·CONCLUSION: CTS in the lumen increases the risk of prolapse, prompting earlier tube removal in patients following DCR for nasolacrimal duct obstruction(NLDO).Earlier removal of tubes does not appear to significantly decrease success rates. | Kira L.Segal Sarah H.Van Tassel Charles Kim Nicole Hsu Ashutosh Kacker Gary J.Lelli Jr | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 0 |
| 13 | Remote light-activation of native Orai channels显示文摘Optogenetic control of the Ca^(2+)signaling machinery has been a powerful approach but requires complex cell manipulation to introduce modified genes.A newly developed non-invasive,ultrafast laser technique allows for the remote activation of native Orai1 Ca^(2+)channels,without the need for gene introduction,protein expression,or exogenous reagents. | Sarah A.Kazzaz James H.Baraniak Jr Yandong Zhou Donald L.Gill | 2021 | Cell Research2021，31，7： | 0 |
| 14 | Comparison of approaches to quantify SARS-CoV-2 in wastewater using RT-qPCR: Results and implications from a collaborative inter-laboratory study in Canada显示文摘Detection of SARS-CoV-2 RNA in wastewater is a promising tool for informing public health decisions during the COVID-19 pandemic.However,approaches for its analysis by use of reverse transcription quantitative polymerase chain reaction(RT-q PCR)are still far from standardized globally.To characterize inter-and intra-laboratory variability among results when using various methods deployed across Canada,aliquots from a real wastewater sample were spiked with surrogates of SARS-CoV-2(gamma-radiation inactivated SARS-CoV-2 and human coronavirus strain 229E[HCoV-229E])at low and high levels then provided'blind'to eight laboratories.Concentration estimates reported by individual laboratories were consistently within a 1.0-log_(10) range for aliquots of the same spiked condition.All laboratories distinguished between low-and high-spikes for both surrogates.As expected,greater variability was observed in the results amongst laboratories than within individual laboratories,but SARS-CoV-2 RNA concentration estimates for each spiked condition remained mostly within 1.0-log_(10) ranges.The no-spike wastewater aliquots provided yielded non-detects or trace levels(<20 gene copies/mL)of SARS-CoV-2 RNA.Detections appear linked to methods that included or focused on the solids fraction of the wastewater matrix and might represent in-situ SARS-CoV-2 to the wastewater sample.HCoV-229E RNA was not detected in the no-spike aliquots.Overall,all methods yielded comparable results at the conditions tested.Partitioning behavior of SARS-CoV-2 and spiked surrogates in wastewater should be considered to evaluate method effectiveness.A consistent method and laboratory to explore wastewater SARS-CoV-2 temporal trends for a given system,with appropriate quality control protocols and documented in adequate detail should succeed. | Alex H.S.Chik Melissa B.Glier Mark Servos Chand S.Mangat Xiao-Li Pang Yuanyuan Qiu Patrick M.D’Aoust Jean-Baptiste Burnet Robert Delatolla Sarah Dorner Qiudi Geng John P.Giesy Jr Robert Mike McKay Michael R.Mulvey Natalie Prystajecky Nivetha Srikanthan Yuwei Xie Bernadette Conant Steve E.Hrudey Canadian SARS-CoV-Inter-Laboratory Consortium | 2021 | Journal of Environmental Sciences2021，33，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员