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您的检索式：作者名="Sarah Macfarlane"
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| 1 | Osteoblastic glucocorticoid signaling exacerbates high-fat-diet-induced bone loss and obesity显示文摘Chronic high-fat diet(HFD)consumption not only promotes obesity and insulin resistance,but also causes bone loss through mechanisms that are not well understood.Here,we fed wild-type CD-1 mice either chow or a HFD(43%of energy from fat)for 18 weeks;HFD-fed mice exhibited decreased trabecular volume(-28%)and cortical thickness(-14%)compared to chow-fed mice.In HFD-fed mice,bone loss was due to reduced bone formation and mineral apposition,without obvious effects on bone resorption.HFD feeding also increased skeletal expression of sclerostin and caused deterioration of the osteocyte lacunocanalicular network(LCN).In mice fed HFD,skeletal glucocorticoid signaling was activated relative to chow-fed mice,independent of serum corticosterone concentrations.We therefore examined whether skeletal glucocorticoid signaling was necessary for HFD-induced bone loss,using transgenic mice lacking glucocorticoid signaling in osteoblasts and osteocytes(HSD2^(OB/OCY)-tg mice).In HSD2^(OB/OCY)-tg mice,bone formation and mineral apposition rates were not suppressed by HFD,and bone loss was significantly attenuated.Interestingly,in HSD2^(OB/OCY)-tg mice fed HFD,both Wnt signaling(less sclerostin induction,increased P | Sarah Kim Holger Henneicke Lauryn L.Cavanagh Eugenie Macfarlane Lee Joanne Thai Daphne Foong Sylvia J.Gasparini Colette Fong-Yee Michael M.Swarbrick Markus J.Seibel Hong Zhou | 2021 | Bone Research2021，9，4： | 2 |
| 2 | Oral Administration of Curcumin Emulsified in Carboxymethyl Cellulose Has a Potent Anti-inflammatory Effect in the IL-10 Gene-Deficient Mouse Model of IBD显示文摘 | Victoria Y. L. Ung Rae R. Foshaug Sarah M. MacFarlane Thomas A. Churchill Jason S. G. Doyle Beate C. Sydora Richard N. Fedorak | 2010 | Digestive Diseases and Sciences2010，，5： | 1 |
| 3 | Acrokeratosis Verruciformis of Hopf is Caused by Mutation in ATP2A2:Evidence That it is Allelic to Darier's Disease显示文摘 | Jittima Dhitavat Sarah Macfarlane Leonard Dode | 2003 | Journal of Investigative Dermatology2003，120，： | 1 |
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