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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA collaboration显示文摘 | Sare GM Ali M Shuaib A | 2009 | Stroke2009，40，6： | 1 |
| 3 | Intermittent pneumatic sequential eompression of the lower extremities restores the cerebral oxygen saturation during laparoscopic eholecysteeto-my显示文摘 | Kurukahveeioglu O Sare M Karamerean A | 2008 | Surg Endosc2008，22，4： | 1 |
| 4 | Is lowering blood pressure hazardous in patients with significant ipsilateral carotid stenosis and acute ischaemic stroke Interim assessment in the 'efficacy of nitric oxide in stroke' trial显示文摘 | SARE G M GRAY L J WARDLAW J | 2009 | Blood Press Monit2009，14，1： | 1 |
| 5 | Microstructure-property relationships in high chromium white iron alloys显示文摘 | Tabrett C P Sare I R Ghomashchi M R | 1996 | International Materials Reviews1996，41，2： | 1 |
| 6 | Microstructure-property relationship in high chromium white iron alloys显示文摘 | Tabrett C P Sare I R Ghomashchi M R | 1996 | International Materials Reviews1996，41，： | 1 |
| 7 | Microstructure-property relationships in high chromium white iron alloys 显示文摘 | Tabrett C Sare I Ghomashchi M | 1996 | International Materials Reviews1996，41，2： | 1 |
| 8 | Microstructureproperty relationships in high chromium white iron alloys显示文摘 | Tabrett C P Sare I R Ghomashchi M R | 1996 | International Materials Reviews1996，41，2： | 1 |
| 9 | Microstructure-property relationship in high chromium white iron alloys显示文摘 | Tabrett C P Sare I R Ghomashchi M R | | 0，，41： | 1 |
| 10 | Microstructure-property relationship in high chromium white iron alloys显示文摘 | TABRETT C P,SARE I R,GHOMASHCHI M R | 1996 | International Materials Review1996，41，2： | 1 |
| 11 | Stability of Timoshenko systems with past history显示文摘 | RIVERA J E M FERNANDEZ SARE H D | 2008 | J Math Anal Appl2008，339，1： | 1 |
| 12 | Relationship between hyperacute blood pressure and outcome after ischemic stroke : data from the VISTA collaboration 显示文摘 | Sare GM Ali M Shuaib A | 2009 | Stroke2009，40，6： | 1 |
| 13 | The effect of carbon dioxide pneumoperitoneum on free radicals显示文摘 | Yilmaz I Hamamci D | 2000 | Surg Endosc2000，14，7： | 1 |
| 14 | Mirizzi syndrome:choice of surgical procedure in the laparoscopic era显示文摘 | Sare M Gurer S Taskin B | 1998 | Surg Laparosc Endosc1998，8，： | 1 |
| 15 | Preoperative left ventricular systolic dysfunction correlates with the adverse postoperative consequences of annular-papillary disconnection in the course of mitral valve replacement for stenosis 显示文摘 | Essop M R Kontozis L Sareli P | 1998 | J Heart Valve Dis1998，7，4： | 1 |
| 16 | Effects of carbon dioxide pneumoperitoneum on free radical formation in lung and liver tissues 显示文摘 | Sare M J Hamamei DG Yilmaz IL | 2002 | Surg Endosc2002，16，3： | 1 |
| 17 | Asymp- tomatic hemorrhagic transformation of infarction and its relationship with functional outcome and stroke subtype: assessment from the Tinzaparin in Acute Ischaemic Stroke Trial显示文摘 | ENGLAND T J BATH P M SARE G M | 2010 | Stroke2010，41，12： | 1 |
| 18 | Microstructure- property relationships in high chromium white iron alloys 显示文摘 | Tabrett C P Sare I R and Ghomashchi M R | 1996 | International Materials Reviews1996，41，2： | 1 |
| 19 | The elemen- tal composition, the microfibril angle distribution and the shape of the cell cross section in Norway spruce xylem显示文摘 | PEURA M SARE'N M LAUKKANEN J etal | 2008 | Trees2008，22，： | 1 |
| 20 | Relationship between hyper acute blood pressure and outcome after ischemic stroke data from the VISTA collaboration显示文摘 | Sare GM Ali M Shuaib A | 2009 | Stroke2009，40，6： | 1 |
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