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| 1 | Does adiuvant steroid therapy post-Kasai portoenterostomy improve the outcome of biliary atresia? A systematic review and meta- analysis显示文摘 | Sarkhy A Schreiber RA Milner RA | 2011 | Can J Gastroenterol2011，25，8： | 1 |
| 2 | Effect of drag-reducing polymers on annular gas-liquid flow in aa horizontal pipe显示文摘 | Hanratty T J | 2001 | Int J Multiphase Flow2001，27，： | 1 |
| 3 | Does adjuvant steroid therapy post-Kasaiportoenterostomy improve the outcome of bili- ary atresia? A systematic review and meta-analysis 显示文摘 | Sarkhy A Schreiber RA Milner R | 2011 | Can J Gastroentero12011，25，8： | 1 |
| 4 | Regional variation of pediatric inflammatory bowel disease in Saudi Arabia: Results from a multicenter study显示文摘BACKGROUND Incidence and severity variations of inflammatory bowel disease(IBD)have been reported from Western populations between continents and regions of the same countries.However,no data were available from other countries.AIM To investigate the regional differences in the IBD profiles of pediatric patients from the Kingdom of Saudi Arabia.METHODS Data from a national multicenter IBD study were used.The incidence,time trend,and clinical presentation of Crohn’s disease(CD)and ulcerative colitis(UC)in the Central region(CR),Western region(WR),and Eastern region(ER)were analyzed and compared.Statistical analysis included Poisson regression analysis for incidence variation and Chi-square test for demographic and clinical parameters.A P<0.05 was considered significant.RESULTS The prevalence of positive family history was lower in children with CD from the ER than the CR or the WR.Consanguinity rate was higher in children with CD and UC from the CR and the ER,respectively.The incidences and time trends of CD and UC were not significantly different between regions.In the ER,a significantly higher percentage of children with CD presented with abdominal pain(P<0.001),blood in stools(P=0.048),stricturing or penetrating disease(P=0.029),higher erythrocyte sedimentation rate(P<0.001),higher C-reactive protein(P<0.001),higher anemia(P=0.017),and lower albumin level(P=0.014).For children with UC from the ER,a significantly higher percentage presented with anemia(P=0.006)and a lower percentage with pancolitis(P<0.001).CONCLUSION The most important finding is the identification of significantly more severe presentation of CD in the ER of the Kingdom of Saudi Arabia.Prospective studies are needed to explain such variations. | Mohammad I El Mouzan Mohammed H AlEdreesi Mohammed Y Hasosah Abdulrahman A Al-Hussaini Ahmad A Al Sarkhy Asaad A Assiri | 2020 | World Journal of Gastroenterology2020，26，4： | 1 |
| 5 | Efficiency of Miller engine at maximum power - density 显示文摘 | Al - Sarkhi A AKASH B A | 2002 | Int Commun Heat Mass Transfer2002，29，： | 1 |
| 6 | Effects of friction and temperature -dependent specific -heat of the working fluid on the performance of a Diesel -engine显示文摘 | Al -Sarkhi A JABER J O Abu -Qudais M PROBERT S D | 2006 | Appl Energy2006，83，： | 1 |
| 7 | Efficiency of a Millerengine 显示文摘 | Al - Sarkhi A JABER J O PROBERT S D | 2006 | Appl Energy2006，83，： | 1 |
| 8 | Does adjuvant steroid therapy post-Kasai portoenterostomy improve outcome of biliary atresia? Systematic review and meta-analysis显示文摘 | Sarkhy A Schreiber RA Milner RA | | 0，，08： | 1 |
| 9 | Does adjuvant steroid therapy post-Kasai portoenterostomy improve the outcome of biliary atresia? A systematic review and meta- analysis显示文摘 | Sarkhy A Schreiber RA Milner RA | 2011 | Can J Gastroenterol2011，25，8： | 1 |
| 10 | Does adju- vant steroid therapy post-Kasai portoenterostomy improve the out- come of biliary atresia? A systematic review and meta-analysis显示文摘 | SARKHY A SCHREIBER R A MILNER R A | 2011 | CanJ Gastroenterol2011，25，8： | 1 |
| 11 | Knowledge and Practice Styles of Pediatricians in Saudi Arabia Regarding Childhood Constipation显示文摘 | Mohammed Hasosah Abdulwahab Telmesani Ali Al-Binali Ahmed Sarkhi Sharifah Alghamdi Khalid Alquair Moath Alturaiki Aziz Alanazi Ashraf Alsahafi Abdullah Alzaben Carlo Di Lorenzo | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，1： | 1 |
| 12 | Fungal dysbiosis predicts the diagnosis of pediatric Crohn's disease显示文摘AIM To investigate the accuracy of fungal dysbiosis inmucosa and stool for predicting the diagnosis of Crohn's disease(CD). METHODS Children were prospectively enrolled in two medical centers: one university hospital and one private gastroenterology clinic in the city of Riyadh, Kingdom of Saudi Arabia. The children with confirmed diagnosis of CD by standard guidelines were considered cases, and the others were considered non-inflammatory bowel disease controls. Mucosal and stool samples were sequenced utilizing Illumina MiSeq chemistry following the manufacturer's protocols, and abundance and diversity of fungal taxa in mucosa and stool were analyzed. Sparse logistic regression was used to predict the diagnosis of CD. The accuracy of the classifier was tested by computing the receiver operating characteristic curves with 5-fold stratified cross-validation under 100 permutations of the training data partition and the mean area under the curve(AUC) was calculated. RESULTS All the children were Saudi nationals. There were 15 children with CD and 20 controls. The mean age was 13.9(range: 6.7-17.8) years for CD children and 13.9(3.25-18.6) years for controls, and 10/15(67%) of the CD and 13/20(65%) of the control subjects were boys. CD locations at diagnosis were ileal(L1) in 4 and colonic(L3) in 11 children, while CD behavior was non-stricturing and non-penetrating(B1) in 12 and stricturing(B2) in 3 children. The mean AUC for the fungal dysbiosis classifier was significantly higher in stools(AUC = 0.85 ± 0.057) than in mucosa(AUC = 0.71 ± 0.067)(P < 0.001). Most fungal species were significantly more depleted in stools than mucosal samples, except for Saccharomyces cerevisiae and S. bayanus, which were significantly more abundant. Diversity was significantly more reduced in stools than in mucosa. CONCLUSION We found high AUC of fungal dysbiosis in fecal samples of children with CD, suggesting high accuracy in predicting diagnosis of CD. | Mohammad I El Mouzan Kirill S Korolev Mohammad A Al Mofarreh Rajita Menon Harland S Winter Ahmad A Al Sarkhy Scot E Dowd Ahmad M Al Barrag Asaad A Assiri | 2018 | World Journal of Gastroenterology2018，24，39： | 1 |
| 13 | Muscle weakness in a girl with autoimmune hepatitis and Graves’ disease显示文摘 | Ahmed Sarkhy Rabindranath Persad Mark Tarnopolsky | 2008 | European Journal of Pediatrics2008，，： | 1 |
| 14 | Energy analysis of Jordan’s commercial sector显示文摘 | JABER JO MOHSEN MS SARKHI A A | 2003 | Energy Policy2003，，9： | 1 |
| 15 | Gut microbiota predicts the diagnosis of ulcerative colitis in Saudi children显示文摘BACKGROUND Ulcerative colitis(UC)is an immune-mediated chronic inflammatory condition with a worldwide distribution.Although the etiology of this disease is still unknown,the understanding of the role of the microbiota is becoming increasingly strong.AIM To investigate the predictive power of the gut microbiota for the diagnosis of UC in a cohort of newly diagnosed treatment-naïve Saudi children with UC.METHODS The study population included 20 children with a confirmed diagnosis of UC and 20 healthy controls.Microbial DNA was extracted and sequenced,and shotgun metagenomic analysis was performed for bacteria and bacteriophages.Biostatistics and bioinformatics demonstrated significant dysbiosis in the form of reduced alpha diversity,beta diversity,and significant difference of abundance of taxa between children with UC and control groups.The receiver operating characteristic curve,a probability curve,was used to determine the difference between the UC and control groups.The area under the curve(AUC)represents the degree of separability between the UC group and the control group.The AUC was calculated for all identified bacterial species and for bacterial species identified by the random forest classification algorithm as important potential biomarkers of UC.A similar method of AUC calculation for all bacteriophages and important species was used.RESULTS The median age and range were 14(0.5-21)and 12.9(6.8-16.3)years for children with UC and controls,respectively,and 40%and 35%were male for children with UC and controls,respectively.The AUC for all identified bacterial species was 89.5%.However,when using the bacterial species identified as important by random forest classification algorithm analysis, the accuracy increased to 97.6%. Similarly, the AUC for all theidentified bacteriophages was 87.4%, but this value increased to 94.5% when the important bacteriophagebiomarkers were used.CONCLUSIONThe very high to excellent AUCs of fecal bacterial and viral species suggest the potential use of noninvasivemicrobiota-based tests for the diagnosis of unusual cases of UC in children. In addition, the identification ofimportant bacteria and bacteriophages whose abundance is reduced in children with UC suggests the potential ofpreventive and adjuvant microbial therapy for UC. | Mohammad El Mouzan Ahmed Al Sarkhy Asaad Assiri | 2024 | World Journal of Clinical Pediatrics2024，13，1： | 0 |
| 16 | Gut microbiota predicts the diagnosis of celiac disease in Saudi children显示文摘BACKGROUND Celiac disease(CeD)is a multisystem immune-mediated multifactorial condition strongly associated with the intestinal microbiota.AIM To evaluate the predictive power of the gut microbiota in the diagnosis of CeD and to search for important taxa that may help to distinguish CeD patients from controls.METHODS Microbial DNA from bacteria,viruses,and fungi,was isolated from mucosal and fecal samples of 40 children with CeD and 39 controls.All samples were sequenced using the HiSeq platform,the data were analyzed,and abundance and diversities were assessed.For this analysis,the predictive power of the microbiota was evaluated by calculating the area under the curve(AUC)using data for the entire microbiome.The Kruskal-Wallis test was used to evaluate the significance of the difference between AUCs.The Boruta logarithm,a wrapper built around the random forest classification algorithm,was used to identify important bacterial biomarkers for CeD.RESULTS In fecal samples,AUCs for bacterial,viral,and fungal microbiota were 52%,58%,and 67.7%respectively,suggesting weak performance in predicting CeD.However,the combination of fecal bacteria and viruses showed a higher AUC of 81.8%,indicating stronger predictive power in the diagnosis of CeD.In mucosal samples,AUCs for bacterial,viral,and fungal microbiota were 81.2%,58.6%,and 35%,respectively,indicating that mucosal bacteria alone had the highest predictive power.Two bacteria,Bacteroides intestinalis and Burkholderiales bacterium 1-1-47,in fecal samples and one virus,Human_endogenous_retrovirus_K,in mucosal samples are predicted to be“important”biomarkers,differentiating celiac from nonceliac disease groups.Bacteroides intestinalis is known to degrade complex arabinoxylans and xylan which have a protective role in the intestinal mucosa.Similarly,several Burkholderiales species have been reported to produce peptidases that hydrolyze gluten peptides,with the potential to reduce the gluten content of food.Finally,a role for Human_endogenous_retrovirus_K in immune-mediated disease such as CeD has been reported.CONCLUSION The excellent predictive power of the combination of the fecal bacterial and viral microbiota with mucosal bacteria alone indicates a potential role in the diagnosis of difficult cases of CeD.Bacteroides intestinalis and Burkholderiales bacterium 1-1-47,which were found to be deficient in CeD,have a potential protective role in the development of prophylactic modalities.Further studies on the role of the microbiota in general and Human_endogenous_retrovirus_K in particular are needed. | Mohammad El Mouzan Asaad Assiri Ahmed Al Sarkhy | 2023 | World Journal of Gastroenterology2023，29，13： | 0 |
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