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| 1 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 2 | Influence of the vertical profile of Saharan dust on the visible direct radiative forcing显示文摘 | Meloni D Sarra A D lorio T D | 2005 | Journal of Quantitative Spectroscopy and Radiative Transfer2005，93，4： | 1 |
| 3 | Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression显示文摘 | Olsen AS Sarras MP Jr Leontovich A | 2012 | Diabetes2012，61，2： | 1 |
| 4 | Influence of vertical profile of Saharan dust on the visible direct radiative forcing 显示文摘 | Meloni D Sarra A D Lorio T D | 2005 | Journal of Quantitative Spectroscopy and Radiative Transfer2005，，4： | 1 |
| 5 | Accuracy and precision in stock separation of north- east Arctic and Norwegian coastal cod by otoliths- comparing readings, image analyses and a genetic method 显示文摘 | Berg E Sarras T H Harbitz A | 2005 | Marine and Freshwater Research2005，56，： | 1 |
| 6 | A random variable shape parameter strategy for radial basis function approximation methods 显示文摘 | SARRA S A STURGILL D | 2009 | Engineering Analysis with Boundary Elements2009，33，5： | 1 |
| 7 | Experimentallymeasured shear stress in the standpipe of a circulatingfluidized bed显示文摘 | Sarra A Miller A L Shadle L J | | 0，，： | 1 |
| 8 | Treatment with interleukin-2(IL-2) and interferon after autologous bone marrow or peripheral blood stem cell transplantation in onco-hematological malignancies with a high risk of relapse显示文摘 | Granena A Jr Sarra J | 1999 | Bone Marrow Transplant1999，23，2： | 1 |
| 9 | Modeling the influ- ence of electron beam irradiation on the heat resistance of Bacillus cereus spores显示文摘 | Valero M Sarras J A Alvarez D | 2006 | Food Microbiology2006，23，： | 1 |
| 10 | Cloning and biological function of laminin in Hydra vulgaris显示文摘 | Sarras MP Jr Yan L Grens A | | 0，，1： | 1 |
| 11 | Influence ofvertical profile of Saharan dust on the visible direct radiativeforcing 显示文摘 | MELONI D SARRA A D LORIO T D | 2005 | Journal of Quantitative Spectroscopy and2005，2005，4： | 1 |
| 12 | Influence of the vertical profile of Saharan dust on the visible direct radiativeforcing显示文摘 | Meloni D Sarra A D Iotio T D | 2005 | J Quant Spectrosc Radiat Transfer2005，93，4： | 1 |
| 13 | Evidence for cell surface extracellular matrix binding proteins in Hydra vulgaris显示文摘 | A(g)ba(s) A Sarras M P Jr | | 0，，1： | 1 |
| 14 | Aerosol optical properities at Lampedusa (Central Mediterranean),1 Influence of transport and identification of different aerosol types显示文摘 | Pace G Sarra A D Meloni D | | 0，，03： | 1 |
| 15 | Jolkinolide diterpenoids and other constituents from Euhorbia hirta显示文摘 | Hazimi A Mohammad H Sarra A | 2008 | J Saudi Chem Soc2008，12，1： | 1 |
| 16 | Adaptive radial basis function methods for time dependent partial differential equations显示文摘 | Sarra S A | 2005 | Applied Numerical Mathematics2005，54，1： | 1 |
| 17 | Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression显示文摘 | Olsen AS Sarras MP Jr Leontovich A | 2012 | Diabetes2012，61，2： | 1 |
| 18 | Mobility of total petroleum hydrocarbons in Shambat soil in Sudan 显示文摘 | All Nuhad M Saad Sarra A M Elamin A | 2014 | World Journal of Science Technology and Sustainable Development2014，11，2： | 1 |
| 19 | Chebyshev super spectral viscosity method for a two-dimensional fluidized bed model显示文摘 | Sarra S A | 2002 | Internation Journal for Numerical Methods in Fluids2002，，4： | 1 |
| 20 | Treatment with interlukin-2 (IL-2) and interferon (IFN (alpha 2b)) after autologous bone marrow or peripheral blood stem cell transplantation in onco-hematological malignancies with a high risk of relapse 显示文摘 | Vivancos P Granena A Jr Sarra J | 1999 | Bone Marrow Transplant1999，23，： | 1 |
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