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| 1 | Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer显示文摘AIM:To study the effect of celecoxib(CXB) on diethylnitrosamine activation through the regulation of cytochrome P450 in a hepatocarcinogenesis model.METHODS:Six-week-old male Sprague-Dawley rats were randomly divided into fi ve groups,a non-treated group(NT) ,a diethylnitrosamine-treated group(DEN) ,a DEN+CXB-treated group(DEN+CXB) ,and CXB 8 d-treated and CXB 32 d-treated groups.The effects of celecoxib on the enzymatic activities of CYP1A1,2A,2B1/2,and 2E1 were assessed in hepatic microsomes 24 h after DEN administration.Changes in CYP1A1 and CYP2B1/2 protein expression were also evaluated.The rate of DEN metabolism was measured by the production of the deethylation metabolite acetaldehyde,and the denitrosation metabolite nitrite.RESULTS:DEN+CXB administration produced a significant increase in the enzymatic activities of CYP2B1/2 and 1A1,whereas it did not change the activities of CYP2A and 2E1,compared to that of the DEN group.CXB treatment for eight days did not produce a signif icant effect on enzymatic activity when compared to the NT group;however,when it was administered for prolonged times(CXB 32 d group) ,the enzymatic activities were increased in a similar pattern to those in the DEN+CXB group.The observed increase in the enzymatic activities in the DEN+CXB group was accompanied by an increase in the CYP2B1/2 protein levels;no changes were observed in the levels of CYP1A1.In vitro,CXB increased the denitrosation of DEN,a pathway of metabolic detoxification.The addition of SKF-525A,a preferential inhibitor of CYP2B,abrogated the denitrosation of DEN.CONCLUSION:These results suggest that the mechanism of action of CXB involves enhancement of the detoxif ication of DEN by an increasing denitrosation via CYP2B1/2. | Martha Estela Salcido-Neyoy Adolfo Sierra-Santoyo Olga Beltrán-Ramírez José Roberto Macías-Pérez Saúl Villa-Trevio | 2009 | World Journal of Gastroenterology2009，15，19： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | The MTS assay as an indicator of chemosensitivity/resistance in malignant gynae- cological turnouts显示文摘 | O'Toole SA Sheppard BL Mcguinness EP | 2003 | Cancer Detect Prev2003，27，1： | 1 |
| 4 | Gene therapy of bone morphogenetic protein for periodontal tissue engineering 显示文摘 | Jin QM Anusaksathien O Webb SA | 2003 | J Periodontol2003，74，2： | 1 |
| 5 | A randomized, double-blind comparison of olanzapine/fluoxetine combination,olanzapine, and fluoxetine in treatment-resistant major depressivedisorder显示文摘 | Thasem E Copya SA Osuntokun O | 2007 | JClin Psychiatry2007，68，2： | 1 |
| 6 | Anti- Helicobacter pylori and urease inhibitory activities of resveratrol and red wine显示文摘 | Luísa Paulo Mónica Oleastro Eugenia Gallardo Jo?o António Queiroz Fernanda Domingues | 2011 | Food Research International2011，，4： | 1 |
| 7 | Potassium leak channels and the KCNK family of two-P- domain subunits显示文摘 | Goldstein SA Bockenhauer D O'Kelly I | 2001 | Nat Rev Neurosci2001，2，3： | 1 |
| 8 | Henoeh Schonlein purpura in childhood: clinical analysis of 254 cases over a 3-year period 显示文摘 | PERU H SOYLEMEZOGLU O BAKKALOGLU SA | 2008 | Clin Rheumatol Belgium2008，27，9： | 1 |
| 9 | Radiological appearances of lymphomas arising from mucosa- associated lymphoid tissue (MALT) in the lung显示文摘 | O'Donnell PG Jackson SA Tung KT | 1998 | Clin Radiol1998，53，1： | 1 |
| 10 | Determination of the fatty acid composition of saponified vegetable oils using matrix-assisted laser dcsorption/ionization time-of-flight mass spectrometry显示文摘 | AYORINDE F O GARVIN K SAED K | 2000 | Rapid Commun Mass Spectrum2000，14，： | 1 |
| 11 | Nurse-based antenatal and child health care in rural India,imple-mentation and effects-an Indian-Swedish collaboration显示文摘 | Alehagen SA Finnstrm O Hermansson GV | 2012 | Rural Remote Health2012，12，： | 1 |
| 12 | Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases显示文摘 | Mandel SA Amit T Weinreb O | 2011 | J Alzheimers Dis2011，25，2： | 1 |
| 13 | PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality显示文摘 | Lopez-Knowles E O Tople SA McNeil CM | | 0，，05： | 1 |
| 14 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 15 | Astrocyte-neuron lactate trans- port is required for long-term memory formation 显示文摘 | Suzuki A Stem SA Bozdagi O | 2011 | Cell2011，144，5： | 1 |
| 16 | Empirical studies assessing the quality of health information for consumers on the world wide web: a systematic review显示文摘 | Eysenbach G Powell J Kuss O Sa ER | 2002 | Jour- nalofthe American Medical Association2002，287，20： | 1 |
| 17 | Periprosthetic frac tures in the resurfaced hip-A case report and review of the lit- erature显示文摘 | Brennan SA Devitt BM O'Neill CJ et a l | 2013 | Injury2013，44，2： | 1 |
| 18 | Gas chromatography/flame ionisation detection mass spectrometry for the detection of endogenous urine metabolites for metabonomic studies and its use as a complementary tool to nuclear magnetic resonance spectroscopy显示文摘 | Fancy SA Beckonert O Darbon G | 2006 | Rapid Commun Mass Spectrom2006，20，15： | 1 |
| 19 | Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response显示文摘 | Bryan SA O'Connor B J Matti S | 2000 | Lancet2000，356，9248： | 1 |
| 20 | Solid lipid nanopariticles for parenterat drug detivery显示文摘 | Cavatti SA Kayser O Muller RH | 2007 | Adv Drug Deliv Rev2007，56，9： | 1 |
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