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| 1 | Concurrent infections of dengue viruses serotype 2 and 3 in patient with severe dengue from Jakarta, Indonesia显示文摘Objective: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses(DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. Methods: Dengue diagnosis was performed using NS1 antigen detection and Ig G/Ig M ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data. DENV concurrent infections were detected and confirmed using RT-PCR and DENV Envelope gene sequencing. Phylogenetic analyses were performed to determine the genotypes of the viruses. Results: The patient was classified as having severe dengue characterized by severe plasma leakage, hemorrhage, and organ damage involving lung, liver, and kidney. Concurrent infection of DENV serotype 2 and 3 was observed. The infecting DENV-2 virus was grouped into Cosmopolitan genotype while DENV-3 virus was classified into Genotype Ⅰ. Both viruses were closely related to isolates that were endemic in Jakarta. Viremia measurement was conducted and revealed a significantly higher virus titer of DENV-3 compared to DENV-2. Conclusions: The occurrence of multi-serotype DENV infections was presented in a patient with severe clinical manifestation in Indonesia. The hyperendemicity of dengue in Indonesia may contribute to the DENV concurrent infections cases and may underlie the severity of the disease. | Soroy Lardo Yaldiera Utami Benediktus Yohan Seri MMU Tarigan Widayat Djoko Santoso Leonard Nainggolan R Tedjo Sasmono | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，2： | 3 |
| 2 | T-cell protein tyrosine phosphatase,distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas,is the nuclear phosphatase of STAT6显示文摘 | Chen J Sasmono RT | 2007 | Mol Cell Biol2007，27，6： | 1 |
| 3 | A macro-phage colony-stimulating factor receptor-green fluorescentprotein transgene is expressed throughout the mononuclearphagocyte system of the mouse显示文摘 | Sasmono RT Oceandy D Pollard JW | 2003 | Blood2003，101，3： | 1 |
| 4 | Nonsyndromic sensorineural deafness associated with the A1555G mutation in the mitochondrial small subunit ribosomal RNA in a Balinese family显示文摘 | Malik S Sudoyo H Sasmono T | 2003 | J Hum 4Genet2003，48，： | 1 |
| 5 | Nonsyndromic sensorineural deafness associated with the A1555G mutation in the mitochondrial small subunit ribosomal RNA in a Balinese family显示文摘 | MALIK S SUDOYO H SASMONO T | 2003 | J Hum Genet2003，48，： | 1 |
| 6 | Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter显示文摘 | Rae F Woods K Sasmono T | | 0，，01： | 1 |
| 7 | Characterisafion and trophic functions of murine embryonic macrophages based upon the use of a Csflr-EGFP transgene reporter显示文摘 | Rae F Woods K Sasmono T | 2007 | Dev Biol2007，308，1： | 1 |
| 8 | Mouse neutrophilic granuiocytes express mRNA encoding the macrophage colony-stimulating factor receptor ( CSF- 1 R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1 显示文摘 | Sasmono RT Ehrnsperger A Cronau SL Ravasi T Kaudane R ttickey MJ | 2007 | J Leukoc Biol2007，82，1： | 1 |
| 9 | Nonsyndromic sensorineural deafness associated with the AI555G mutation in the mitochondrial small subunit ribosomal RNA in a Balinese family显示文摘 | Malik S Sudoyo H Sasmono T | 2003 | J Hum Genet2003，48，3： | 1 |
| 10 | Nonsyndromic sensorineural deafness associated with the A1555G mutation in the mitochondrial small subunit ribosomal RNA in a Balinese family显示文摘 | S. Malik H. Sudoyo T. Sasmono S. Winata I. N. Arhya P. Pramoonjago W. Sudana S. Marzuki | 2003 | Journal of Human Genetics2003，，3： | 1 |
| 11 | Inhibitory Effect of Alpha‑Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells显示文摘Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease.The active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional medicine and dietary supplement.We examined the effect ofα-mangostin against dengue virus(DENV)infection in human peripheral blood mononuclear cells(PBMC)by the measurement of virus titer and TNF-αand IFN-γcytokines concentration post infection.Increasing concentration ofα-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24-and 48-h post infection.Our results support the potential use ofα-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue. | Zaenal Sugiyanto Benediktus Yohan Soeharyo Hadisaputro Edi Dharmana Catharina Suharti Winarto Kis Djamiatun Fifin LRahmi R.Tedjo Sasmono | 2019 | Natural Products and Bioprospecting2019，9，5： | 0 |
| 12 | Modifiable determinants of attitude towards dengue vaccination among healthy inhabitants of Aceh,Indonesia:Findings from a community-based survey显示文摘Objective:To explore and understand the attitude towards dengue vaccination and its modifiable determinants among inhabitants of Aceh(northern Sumatra Island,Indonesia),the region that was most severely affected by the earthquake and tsunami of 26 December 2004.Methods:A communitybased,cross-sectional study was conducted among 535 healthy inhabitants in nine regencies(Kabupaten or Kotamadya) of Aceh that were selected randomly from November 2014 to March 2015.A set of validated,pre-tested,structured questionnaires was used to guide the interviews.The questionnaires covered a range of explanatory variables and one outcome variable(attitude to dengue vaccination).Multi-step logistic regression analysis and Spearman's rank correlation were used to test the role of explanatory variables for the outcome variable.Results:More than 70%of the participants had a poor attitude towards dengue vaccination.Modifiablc determinants associated with poor attitude to dengue vaccination were low education level,working as farmers and traditional market traders,low socioeconomic status and poor knowledge,attitude and practice regarding dengue fever(P<0.05).The KAP domain scores were correlated strongly with attitude to dengue vaccination,r_s=0.25,r_S=0.67 and r_s=0.20,respectively(P<0.001).Multivariate analysis found that independent predictors associated with attitude towards dengue vaccination among study participants were only sex and attitude towards dengue fever(P<0.001).Conclusions:This study reveals that low KAP regarding dengue fever,low education level and low socioeconomic status are associated with a poor attitude towards dengue vaccination.Therefore,inhabitants of suburbs who are working as larmers or traditional market traders with low socioeconomic status are the most appropriate target group for a dengue vaccine introduction program. | Harapan Harapan Samsul Anwar Aslam Bustaman Arsil Radiansyah Pradiba Angraini Riny Fasli Salwiyadi Salwiyadi Reza Akbar Bastian Ade Oktiviyari Imaduddin Akmal Muhammad Iqbalamin Jamalul Adil Fenni Henrizal Darmayanti Darmayanti Rovy Pratama Jhony Karunia Fajar Abdul Malik Setiawan Mandira Lamichhane Dhimal Ulrich Kuch David Alexander Groneberg R.Tedjo Sasmono Meghnath Dhimal Ruth Mueller | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，11： | 0 |
| 13 | The Concept of MDSA (Macro Demand Spatial Approach) on Spatial Demand Forecasting for Main Development Area in Transmission Planning显示文摘 | Djoko Darwanto Sudarmono Sasmono Ngapuli Irmea Sinisuka Mukmin Widyanto Atmopawiro | 2014 | Journal of Energy and Power Engineering2014，8，6： | 0 |
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