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| 1 | MicroRNA in TLR signaling and endotoxin tolerance显示文摘Toll-like receptors(TLRs)in innate immune cells are the prime cellular sensors for microbial components.TLR activation leads to the production of proinflammatory mediators and thus TLR signaling must be properly regulated by various mechanisms to maintain homeostasis.TLR4-ligand lipopolysaccharide(LPS)-induced tolerance or cross-tolerance is one such mechanism,and it plays an important role in innate immunity.Tolerance is established and sustained by the activity of the microRNA miR-146a,which is known to target key elements of the myeloid differentiation factor 88(MyD88)signaling pathway,including IL-1 receptor-associated kinase(IRAK1),IRAK2 and tumor-necrosis factor(TNF)receptor-associated factor 6(TRAF6).In this review,we comprehensively examine the TLR signaling involved in innate immunity,with special focus on LPS-induced tolerance.The function of TLR ligand-induced microRNAs,including miR-146a,miR-155 and miR-132,in regulating inflammatory mediators,and their impact on the immune system and human diseases,are discussed.Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases. | Md A Nahid Minoru Satoh Edward KL Chan | 2011 | Cellular & Molecular Immunology2011，8，5： | 34 |
| 2 | Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis显示文摘 | Sakai Y Masamune A Satoh A | 2003 | Gastroenterology2003，124，3： | 1 |
| 3 | Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice显示文摘 | Satoh A Cho EJ | 2004 | J Pharm Pharmacol2004，56，： | 1 |
| 4 | Clinicopathological study on liver dysfunction in mensles显示文摘 | Satoh A Kobayshi H Yodhida T | 1999 | Internal Med1999，38，5： | 1 |
| 5 | A prospective study on the effects of early surgery on vasospasm after subarachnoid hemorrhage显示文摘 | Yoshimoto Y Wakai S Satoh A | 1999 | Surg Neurol1999，51，4： | 1 |
| 6 | Starch-branching enzyme I -deficient mutation specifically affects the structure and properties of starch in rice endosperm显示文摘 | Satoh H Nishi A Yamashita K | 2003 | Plant Physiology2003，133，： | 1 |
| 7 | Production of polyhydroxyalkanoates (PHA) by activated sludge treating municipal wastewater: effect of pH, sludge retention time (SRT), and acetate concentration in influent 显示文摘 | Chua A S M Takabatake H Satoh H | 2003 | War Res2003，37，： | 1 |
| 8 | Ascites of rat experimental model of severe acute pancreatitis induces lung injury 显示文摘 | Fujita M Masamune A Satoh A | 2001 | Pancreas2001，22，4： | 1 |
| 9 | Immune modulation and expression of cytokine genes in rainbow trout Oncorhynchus mykiss upon probiotic feeding 显示文摘 | Panigrahi A Kiron V Satoh S | 2007 | Developmental & Comparative Immunology2007，31，： | 1 |
| 10 | Age-associated loss of Sirt1-mediated enhancement of glucose stimulated insulin secretion in beta cell-specific Sirt1-overexpressing(BESTO)mice显示文摘 | Ramsey KM Mills KF Satoh A | 2008 | Aging Cell2008，7，1： | 1 |
| 11 | Intraparechymal and intrasylvian haenmtomas secondary to mptured middle cerebral artery aneurysms: prognostic factors and therapeutic considerations 显示文摘 | Yoshimoto Y Wakai S Satoh A | 1999 | Br J Neurosurg1999，13，1： | 1 |
| 12 | Ponsin/SH3P12:an l-afadin-and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions显示文摘 | MANDAI K NAKANISHI H SATOH A | 1999 | J Cell Biol1999，144，5： | 1 |
| 13 | Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice显示文摘 | Yokozawa T Satoh A Cho EJ | 2004 | J Pharm Pharmacol2004，56，1： | 1 |
| 14 | Intraparenchymal and intrasylvian hematomas secondary to ruptured middle cerebral artery aneurysms:prognostic factors and therapeutic considerations显示文摘 | Yoshimoto Y Wakai S Satoh A | 1999 | Br J Neurosurg1999，13，1： | 1 |
| 15 | Generalized Network Voronoi Diagrams: Concepts, Computa- tional Methods, and Applications显示文摘 | Okabe A Satoh T Furuta T | 2008 | International Journal 05 Geographical Information Science2008，22，9： | 1 |
| 16 | Water glass bonding 显示文摘 | SATOH A | 1999 | Sensors and Actua tors: A1999，72，2： | 1 |
| 17 | The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection显示文摘 | Satoh T Takeuchi O Vandenbon A | 2010 | Nat Immunol2010，11，10： | 1 |
| 18 | Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis 显示文摘 | Sakai Y Masamune A Satoh A | 2003 | Gastroenterology2003，124，： | 1 |
| 19 | Inhibition of nuclear factor-kB activation improves the survival of rats with taurocholate pancreatitis显示文摘 | A Satoh T Shimosegawa M Fujita | 1999 | Gut1999，44，： | 1 |
| 20 | Fine structure of cholesterolosis in the human gallbladder and the medchanism of lipid accumulation显示文摘 | Satoh H Koga A | 1997 | Microse Res Tech1997，39，1： | 1 |
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