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| 1 | Adipose-derived stem cells:Pathophysiologic implications vs therapeutic potential in systemic sclerosis显示文摘Adipose-derived stem cells(ADSCs)residing in the stromal vascular fraction(SVF)of white adipose tissue are recently emerging as an alternative tool for stem cell-based therapy in systemic sclerosis(SSc),a complex connective tissue disorder affecting the skin and internal organs with fibrotic and vascular lesions.Several preclinical and clinical studies have reported promising therapeutic effects of fat grafting and autologous SVF/ADSC-based local treatment for facial and hand cutaneous manifestations of SSc patients.However,currently available data indicate that ADSCs may represent a double-edged sword in SSc,as they may exhibit a pro-fibrotic and anti-adipogenic phenotype,possibly behaving as an additional pathogenic source of pro-fibrotic myofibroblasts through the adipocyte-to-myofibroblast transition process.Thus,in the perspective of a larger employ of SSc-ADSCs for further therapeutic applications,it is important to definitely unravel whether these cells present a comparable phenotype and similar immunosuppressive,anti-inflammatory,anti-fibrotic and pro-angiogenic properties in respect to healthy ADSCs.In light of the dual role that ADSCs seem to play in SSc,this review will provide a summary of the most recent insights into the preclinical and clinical studies employing SVF and ADSCs for the treatment of the disease and,at the same time,will focus on the main findings highlighting the possible involvement of these stem cells in SSc-related fibrosis pathogenesis. | Irene Rosa Eloisa Romano Bianca Saveria Fioretto Marco Matucci-Cerinic Mirko Manetti | 2021 | World Journal of Stem Cells2021，13，1： | 3 |
| 2 | 猪精子细胞中胰岛素诱导产生的一氧化氮自由基促进精子获能显示文摘近期,胰岛素被证实具有诱导猪精子获能的能力。在不同的哺乳动物中,精子获能被认为与一氧化氮信号通路相关;因此,本研究使用荧光激活细胞分选技术探究经胰岛素处理的猪精子中一氧化氮水平。在同一样本中,用金霉素染色、蛋白质酪氨酸磷酸化模式和顶体状态来评估精子获能。结果显示经胰岛素处理的精子内一氧化氮水平及三种评价精子获能的指标均有显著提高;相反,用一氧化氮合成酶抑制剂(N-硝基-L-精氨酸甲酯)或抗胰岛素受体β抗体预处理的精子中胰岛素相关的作用全被逆转。这些结果表明胰岛素具有增强猪精子细胞内一氧化氮浓聚的能力并且提示胰岛素可能通过一氧化氮促进精子获能。 | Saveria Aquila Francesca Giordano Carmela Guido Vittoria Rago Amalia Carpino | 2013 | Asian Journal of Andrology2013，15，6： | 2 |
| 3 | The Role of Oxidative Stress and Autophagy in Atherosclerosis显示文摘 | Ida Perrotta Saveria Aquila David Pattison | 2015 | Oxidative Medicine and Cellular Longevity2015，，： | 1 |
| 4 | Growth factors sustain primordial germ cell survival, proliferation and entering into meiosis in the absence of somatic cells 显示文摘 | Donatella F Maria L S Saveria I | 2005 | Dev Biol2005，285，1： | 1 |
| 5 | Differential modulation of stress-inflammation responses by plant polyphenols in cultured normal human keratinocytes and immortalized HaCaT cells显示文摘 | Saveria Pastore Daniela Lulli Alla I. Potapovich Paolo Fidanza Vladimir A. Kostyuk Elena Dellambra Chiara De Luca Riccardo Maurelli Liudmila G. Korkina | 2011 | Journal of Dermatological Science2011，，2： | 1 |
| 6 | The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs)显示文摘 | Marco Pupo Adele Vivacqua Ida Perrotta Assunta Pisano Saveria Aquila Sergio Abonante Anna Gasperi-Campani Vincenzo Pezzi Marcello Maggiolini | 2013 | Molecular and Cellular Endocrinology . 2013 (1-2)2013，，： | 1 |
| 7 | Sodium butyrate sensitises human pancreatic cancer cells to both the intrinsic and the extrinsic apoptotic pathways显示文摘 | Federica Natoni Laura Diolordi Claudio Santoni Maria Saveria Gilardini Montani | 2005 | BBA - Molecular Cell Research2005，，3： | 1 |
| 8 | Comparison between hepatocellular carcinoma prognostic scores:A 10-year single-center experience and brief review of the current literature显示文摘BACKGROUND Hepatocellular carcinoma(HCC)represents the most common primitive liver malignancy.A relevant concern involves the lack of agreement on staging systems,prognostic scores,and treatment allocation algorithms.AIM To compare the survival rates among already developed prognostic scores.METHODS We retrospectively evaluated 140 patients with HCC diagnosed between February 2006 and November 2017.Patients were categorized according to 15 prognostic scoring systems and estimated median survivals were compared with those available from the current medical literature.RESULTS The median overall survival of the cohort of patients was 35(17;67)mo,and it was statistically different in relation to treatment choice,ultrasound surveillance,and serum alpha-fetoprotein.The Italian Liver Cancer(ITA.LI.CA)tumor staging system performed best in predicting survival according to stage allocation among all 15 evaluated prognostic scores.Using the ITA.LI.CA prognostic system,28.6%,40.7%,22.1%,and 8.6%of patients fell within stages 0-1,2-3,4-5 and>5 respectively.The median survival was 57.9 mo for stages 0-1,43 mo for stages 2-3,21.7 mo for stages 4-5,and 10.4 mo for stage>5.The 1-,3-,and 5-year survival rates were respectively 95%,65%,and 20%,for stages 0-1;94.7%,43.9%and 26.3%for stages 2-3;71%,25.8%and 16.1%for stages 4-5;and 50%,16.7%and 8.3%for stage>5.At the same time,although statistically significant in prognostic stratification,the most commonly used Barcelona Clinic Liver Cancer system showed one of the most relevant differences in median survival,especially for stages A and C,when compared to the medical literature.In fact,10.7%,59.3%,27.1%,1.4%,and 0%of patients were stratified into stages 0,A,B,C,and D respectively.The median survival was>81.1 mo for stage 0,44.9 mo for stage A,21.3 mo for stage B,and 3.1 mo for stage C.The 1-,3-,and 5-year survival rates were respectively 86.7%,60%,and 46.7%for stage 0;91.6%,50.6%,and 20.5%for stage A;73.7%,23.7%and 13.2%for stage B;and 2%,0%and 0%for stage C.CONCLUSION Survival analysis shows excellent prognostic ability of the ITA.LI.CA scoring system compared to other staging systems. | Michele Campigotto Mauro Giuffrè Anna Colombo Alessia Visintin Alessandro Aversano Martina Budel Flora Masutti Cristiana Abazia Lory Saveria Croce | 2020 | World Journal of Hepatology2020，12，12： | 1 |
| 9 | Dasatinib in the management of lymphoid blast crisis of Philadelphia-positive chronic myeloid leukemia with multiple extra-medullary and intracranial localizations显示文摘 | Giuliana Alimena Massimo Breccia Roberto Latagliata Sara Grammatico Angela Matturro Saveria Capria Maria Stefania De Propris Daniela Diverio Giovanna Meloni | 2009 | Leukemia Research2009，，8： | 1 |
| 10 | Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors显示文摘 | Saveria Pastore Daniela Lulli Giampiero Girolomoni | 2014 | Archives of Toxicology2014，，6： | 1 |
| 11 | Verbascum xanthophoeniceum derived phenylethanoid glycosides are potent inhibitors of inflammatory chemokines in dormant and interferon- gamma stimulated human keratinocytes 显示文摘 | Mileu Georgiev Saveria Pastore Daniela Lulli | 2012 | J Ethnopharmacol2012，144，： | 1 |
| 12 | Growth factors sustain primordial germ cell survival,proliferation and entering into meiosis in the absence of somatic cells显示文摘 | Donatella F Maria L S Saveria I | 2005 | Developmental Biology2005，，285： | 1 |
| 13 | The effect of sample hemolysis on cardiac troponin I and T assay显示文摘 | Giovanni B Saveria C Roberta DD | 2010 | Clin Chem2010，56，8： | 1 |
| 14 | Subcellular location of APE-1/Ref-1 in human hepatoceilular carcinoma: possible prognostic significance 显示文摘 | VITTORIO DI MASO CLAUDIO AVELLINI LORY SAVERIA CROCe | 2007 | Molecular Medicine2007，13，12： | 1 |
| 15 | Taguchi-Optimized Catalytic Growth of Carbon Nanotubes for Applications in Electro-Catalysis显示文摘 | Saveria Santangelo Elpida Piperopoulos Giuliana Faggio Maurizio Lanza Giacomo Messina Candida Milone | 2013 | Journal of Chemistry and Chemical Engineering2013，7，8： | 0 |
| 16 | Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma显示文摘Background and Aims:Identification of prognostic factors for hepatocellular carcinoma(HCC)opens new perspectives for therapy.Circulating and cellular onco-miRNAs are noncoding RNAs which can control the expression of genes involved in oncogenesis through post-transcriptional mechanisms.These microRNAs(miRNAs)are considered novel prognostic and predictive factors in HCC.The apurinic/apyrimidinic endodeoxyribonuclease 1(APE1)contributes to the quality control and processing of specific onco-miRNAs and is a negative prognostic factor in several tumors.The present work aims to:a)define APE1 prognostic value in HCC;b)identify miRNAs regulated by APE1 and their relative target genes and c)study their prognostic value.Methods:We used The Cancer Genome Atlas(commonly known as TCGA)data analysis to evaluate the expression of APE1 in HCC.To identify differentially-expressed miRNAs(DEmiRNAs)upon APE1 depletion through specific small interfering RNA,we used NGS and nanostring approaches in the JHH-6 HCC tumor cell line.Bioinformatics analyses were performed to identify signaling pathways involving APE1-regulated miRNAs.Microarray analysis was performed to identify miRNAs correlating with serum APE1 expression.Results:APE1 is considerably overexpressed in HCC tissues compared to normal liver,according to the TCGA-liver HCC(known as LIHC)dataset.Enrichment analyses showed that APE1-regulated miRNAs are implicated in signaling and metabolic pathways linked to cell proliferation,transformation,and angiogenesis,identifying Cyclin Dependent Kinase 6 and Lysosomal Associated Membrane Protein 2 as targets.miR-33a-5p,miR-769,and miR-877 are related to lower overall survival in HCC patients.Through array profiling,we identified eight circulating DE-miRNAs associated with APE1 overexpression.A training phase identified positive association between sAPE1 and miR-3180-3p and miR-769.Conclusions:APE1 regulates specific miRNAs having prognostic value in HCC. | Giovanna Mangiapane Devis Pascut Emiliano Dalla Giulia Antoniali Monica Degrassi Lory Saveria Crocè Veronica De Sanctis Silvano Piazza Giulia Canarutto Claudio Tiribelli Gianluca Tell | 2023 | Journal of Clinical and Translational Hepatology2023，11，6： | 0 |
| 17 | High fecal calprotectin levels are associated with SARS-CoV-2 intestinal shedding in COVID-19 patients:A proof-of-concept study显示文摘BACKGROUND One third of coronavirus disease 2019(COVID-19)patients have gastrointestinal symptoms.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA has been detected in stool samples of approximately 50%of COVID-19 individuals.Fecal calprotectin is a marker of gastrointestinal inflammation in the general population.AIM To investigate if fecal calprotectin correlates with SARS-CoV-2 intestinal shedding in COVID-19 patients with pneumonia.METHODS Patients with SARS-CoV-2 pneumonia admitted to the Infectious Disease Unit(University Hospital of Trieste,Italy)from September to November 2020 were consecutively enrolled in the study.Fecal samples were collected and analyzed for quantification of fecal calprotectin(normal value<50 mg/kg)and SARS-CoV-2 RNA presence by polymerase chain reaction(PCR).Inter-group differences were determined between patients with and without diarrhea and patients with and without detection of fecal SARS-CoV-2.RESULTS We enrolled 51 adults(40 males)with SARS-CoV-2 pneumonia.Ten patients(20%)presented with diarrhea.Real-time-PCR of SARS-CoV-2 in stools was positive in 39 patients(76%),in all patients with diarrhea(100%)and in more than two thirds(29/41,71%)of patients without diarrhea.Obesity was one of the most common comorbidities(13 patients,25%);all obese patients(100%)(P=0.021)tested positive for fecal SARS-CoV-2.Median fecal calprotectin levels were 60 mg/kg[interquartile range(IQR)21;108];higher fecal calprotectin levels were found in the group with SARS-CoV-2 in stools(74 mg/kg,IQR 29;132.5)compared to the group without SARS-CoV-2(39 mg/kg,IQR 14;71)(P<0.001).CONCLUSION High fecal calprotectin levels among COVID-19 patients correlate with SARSCoV-2 detection in stools supporting the hypothesis that this virus can lead to bowel inflammation and potentially to the‘leaky gut’syndrome. | Verena Zerbato Stefano Di Bella Mauro Giuffrè Anna Wladyslawa Jaracz Ylenia Gobbo Diego Luppino Paolo Macor Ludovica Segat Raffaella Koncan Pierlanfranco D'Agaro Michael Valentini Lory Saveria Crocé Maurizio Ruscio Roberto Luzzati | 2021 | World Journal of Gastroenterology2021，27，22： | 0 |
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