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| 1 | Measurement uncertainty in pharmaceutical analysis and its application显示文摘The measurement uncertainty provides complete information about an analytical result. This is very important because several decisions of compliance or non-compliance are based on analytical results in pharmaceutical industries. The aim of this work was to evaluate and discuss the estimation of uncertainty in pharmaceutical analysis. The uncertainty is a useful tool in the assessment of compliance or non-compliance of in-process and final pharmaceutical products as well as in the assessment of pharmaceutical equivalence and stability study of drug products. | Marcus Augusto Lyrio Traple Alessandro Morais Saviano Fabiane Lacerda Francisco Felipe Rebello Lourencon | 2014 | Journal of Pharmaceutical Analysis2014，4，1： | 8 |
| 2 | Combined therapy with bevacizumab and photodynamic therapy for myopic choroidal neovascularization: A oneyear follow-up controlled study显示文摘AIM:To evaluate the efficacy and safety of a combined treatment for myopic choroidal neovascularization(CNV)using photodynamic therapy(PDT)and intravitreal bevacizumab and to compare it with intravitreal bevacizumab monotherapy.METHODS:Thirty-four eyes with angiographic evidence of myopic CNV were randomly divided into two groups:17 were treated with one intravitreal bevacizumab injection(1.25 mg)and low-fluence-rate PDT within seven days of the injection(Group A).The other 17 received monotherapy with bevacizumab injections(Group B).Clinical evidence of complications,best corrected visual acuity(BCVA)and fluorescein leakage were evaluated.BCVA and optical coherence tomography(OCT)were evaluated monthly.The timepoints follow-up was established at 6 and 12mo.All patients were retreated following a PRN protocol.RESULTS:A total of 34 eyes of 34 patients(26 women and 8 men)with a mean age of 62.35 years were included.In Group A(17 eyes)the mean BCVA increased from 0.55±0.13 logMAR before the treatment to 0.40±0.09 logMAR at the 12mo follow-up(P<0.01).In Group B(17 eyes)the mean BCVA increased from 0.60±0.11 logMAR before the treatment to 0.55±0.12 logMAR at the 12mo follow-up(P<0.01).There was no statistically significant difference between the two groups in terms of LogMar visual acuity.In Group A the mean number of combined treatments was 1.8±0.11 per patient;in Group B the mean number of intravitreal bevacizumab injections was3.1±0.08 per patient.The number of treatments was significantly fewer in Group A(P<0.01).No local or systemic side effects occurred among any of the patients treated in this study.CONCLUSION:The combination of anti-angiogenic injections and PDT appears to be a safe and effective option for myopic CNV treatment and allows for a significant reduction of intravitreal injections. | Sandro Saviano Rita Piermarocchi Pia E.Leon Alessandro Mangogna Andrea Zanei Fabiano Cavarzeran Sc Daniele Tognetto | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 5 |
| 3 | Spontaneous or secondary to intravitreal injections of anti-angiogenic agents retinal pigment epithelial tears in age-related macular degeneration显示文摘·AIM:Toevaluatethevisualfunctionevolutionofretinal pigment epithelial(RPE) tears in patients with age-related macular degeneration(AMD) according to type of occurrence [spontaneous or secondary to anti-vascular endothelial growth factor(anti-VEGF) injection] and the topographic location of the tear after a two-year followup period.·METHODS: A total of 15 eyes of 14 patients with RPE tears in exudative AMD were analyzed retrospectively at the University Eye Clinic of Trieste. Inclusion criteria were: patient age of 50 or older with AMD and RPE tears both spontaneous occurring or post anti-VEGF treatment. Screening included: careful medical history,complete ophthalmological examination, fluorescein angiography(FA), indocyanine green angiography(ICG),autofluorescence and infrared imaging and optical coherence tomography(OCT). Patients were evaluated every month for visual acuity(VA), fundus examination and OCT. Other data reported were: presence of PED,number of injections before the tear, location of the lesion.·RESULTS:Meanfollow-up was24wk(SD±4wk). Atotal of 15 eyes were studied for RPE tear. In 6 cases(40%),the RPE tears occurred within two years of anti-VEGF injections the others occurred spontaneously. In 13cases(86.6%), the RPE tear was associated with pigment epithelial detachment(PED). In 7 cases(46.6%), the RPE tear occurred in the central area of the retina and involved the fovea. Two lesions were found in the parafoveal region, six in the extra-macular area. In all cases visual acuity decreased at the end of the follow-up period(P <0.01) independently of the type or the topographical location of the lesion.·CONCLUSION: RPE tear occurs in exudative AMD as a spontaneous complication or in relation to anti-VEGF injections. Visual acuity decreased significantly and gradually in the follow-up period in all cases. No correlation was found between visual loss and the type of onset or the topographic location of the tears. | Pia E.Leon Sandro Saviano Andrea Zanei Marco R.Pastore Elvira Guaglione Alessandro Mangogna Daniele Tognetto | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 3 |
| 4 | Liver Involvement in Obese Children (Ultrasonography and Liver Enzyme Levels at Diagnosis and During Follow-up in an Italian Population)显示文摘 | Maria Carmela Saviano Francesco Brunetti Armido Rubino Adriana Franzese Pietro Vajro Alessandro Argenziano Alessandro Puzziello Maria Pina Iannucci | 1997 | Digestive Diseases and Sciences1997，，7： | 3 |
| 5 | Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures显示文摘二进制不对称的 nanocrystals (BNC ) ,加入的光敏的 TiO 2 nanorod 填写了 superparamagnetic -Fe2O3 球形的领域,在聚乙烯乙二醇被嵌入修改 phospholipid micelle 并且成功地 bioconjugated 到包含一个 RGD 主题的合适设计的肽。BNC 表示由于在一个粒子的二个不同领域的共存,相关多功能的 nanomaterial 由高 photoactivity 和磁性描绘了,那特别地在生物成像用作光线疗法和过高热代理人以及一根磁性的探针被适合。我们选择了 RGD 主题以便指向在激活的 endothelial 房间和癌症房间的几种类型上表示的 integrin。准备 RGD-peptide/BNC 结合,包括地由使用互补光、结构的技术监视了,在生物媒介表明了高稳定性和一致可分散性。RGD-peptide/BNC 的 cytotoxicity 结合在 vitro 被学习。RGD 肽的细胞的举起在房间结合,在房间 lysates 借助于二条不同途径,也就是共焦的显微镜学分析和排放光谱学决心估计了, RGD-peptide-BNC 的显示的选择为 v3 integrin 结合。这些 RGD-peptide-BNC 结合为癌症的 theranostic 治疗有一个高潜力。 | Gianpiero Valente Nicoletta Depalo Ivan de Paola Rosa Maria lacobazzi Nunzio Denora Valentino Laquintana Roberto Comparelli Emiliano Altamura Tiziana Latronico Michele Altomare Elisabetta Fanizza Marinella Striccoli Angela Agostiano Michele Saviano Annarita Del Gatto Laura Zaccaro Maria Lucia Curri | 2016 | Nano Research2016，9，3： | 2 |
| 6 | Irrigated-tip magnetic catheter ablation of AF: a long-term prospective study in 130 patients显示文摘 | Zuffada F Saviano M Pappone A | 2011 | Heart Rhythm2011，8，1： | 1 |
| 7 | Nephrotic edema显示文摘 | De Santo NG Pollastro RM Saviano C | 2001 | Semin Nephrol2001，21，2： | 1 |
| 8 | Grid laser treatment in macular branch retinal vein occlusion显示文摘 | Battaglia Parodi M Saviano S Ravalico G | 1999 | Graefes Arch Clin Exp Ophthalmol1999，237，12： | 1 |
| 9 | Nephrotic edema显示文摘 | De Santo NG Pollastro RM Saviano C | 2001 | Semin Nephrol2001，21，： | 1 |
| 10 | Nephrotic edema显示文摘 | De Santo NG Pollastro RM Saviano C Pascale C Di Stasio V Chiricone D | 2001 | Semin Nephrol2001，21，3： | 1 |
| 11 | Carotenoids and antioxidants in age-related mae ulopathy Italian study: Multifocal electroretinogram modifications after 1 year 显示文摘 | Parisi V Tedeschi M Gallinaro G Varano M Saviano S Piermarocchi S | 2008 | Ophthalmology2008，115，3： | 1 |
| 12 | Histomorphometric stud- y of dental pulp during orthodontic tooth movement显示文摘 | Nixon CE Saviano JA King GJ | | J Eltdod 993 19(1 ) :13 - 160，，： | 1 |
| 13 | New antitumour cyclic as- tin analogues : synthesis, conformation and bioactivity 显示文摘 | Rossi F Zanotti G Saviano M | 2004 | Jour- nal of Peptide Science2004，10，2： | 1 |
| 14 | Influence of confor- mational flexibility on biological activity in cyclic astin analogues 显示文摘 | Saviano G Benedetti E Cozzolino R | 2004 | Peptide Science2004，76，6： | 1 |
| 15 | Gvid laser treatment in macular branch retinal vein occlusion显示文摘 | Parodi MB Saviano S Ravalico G | 1999 | Graefe''s Arch Clin Exp Ophthalmol1999，237，： | 1 |
| 16 | Long-termeffectiveness of Radiofrequency Ablation for solitary smallHepatocellular Carcinoma : A retrospective analysis of 363patients显示文摘 | Francica G Saviano A De Sio I | 2013 | Dig Liver Dis2013，45，4： | 1 |
| 17 | Histomorpho- metric study of dental pulp during orthodontic tooth move- ment 显示文摘 | Nixon CE Saviano JA King GJ Keeling SD | 1993 | J Endod1993，19，： | 1 |
| 18 | Nephrotic edema显示文摘 | De Santo N G Pollastro R M Saviano C | | 0，，3： | 1 |
| 19 | Pulmonary vein isolation after circumferential pulmonary vein ablation:comparison between Lasso and three-dimensional electroanatomical assessment of complete electrical disconnection显示文摘 | Augello G Vicedomini G Saviano M | 2009 | Heart Rhythm2009，6，12： | 1 |
| 20 | Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma显示文摘AIM To characterize the survival of cirrhotic patients with Barcelona Clinic Liver Cancer(BCLC) stage C hepatocellular carcinoma(HCC) and to ascertain the factors predicting the achievement of disease control(DC).METHODS The cirrhotic patients with BCLC stage C HCC evaluated by the Hepatocatt multidisciplinary group were subjected to the investigation. Demographic, clinical and tumor features, along with the best tumor response and overall survival were recorded. RESULTS One hundred and ten BCLC stage C patients were included in the analysis; the median overall survival was 13.4 mo(95%CI: 10.6-17.0). Only alphafetoprotein(AFP) serum level > 200 ng/m L and DC could independently predict survival but in a time dependent manner, the former was significantly associated with increased risk of mortality within the first 6 mo of follow-up(HR = 5.073, 95%CI: 2.159-11.916, P = 0.0002), whereas the latter showed a protective effect against death after one year(HR = 0.110, 95%CI: 0.038-0.314, P < 0.0001). Only patients showing microvascular invasion and/or extrahepatic spread recorded lower chances of achieving DC(OR = 0.263, 95%CI: 0.111-0.622, P = 0.002).CONCLUSION The BCLC stage C HCC includes a wide heterogeneous group of cirrhotic patients suitable for potentially curative treatments. The reverse and time dependent effect of AFP serum level and DC on patients' survival confers them as useful predictive tools for treatment management and clinical decisions. | Francesca Romana Ponziani Irene Spinelli Emanuele Rinninella Lucia Cerrito Antonio Saviano Alfonso Wolfango Avolio Michele Basso Luca Miele Laura Riccardi Maria Assunta Zocco Brigida Eleonora Annicchiarico Matteo Garcovich Marco Biolato Giuseppe Marrone Anna Maria De Gaetano Roberto Iezzi Felice Giuliante Fabio Maria Vecchio Salvatore Agnes Giovanni Addolorato Massimo Siciliano Gian Lodovico Rapaccini Antonio Grieco Antonio Gasbarrini Maurizio Pompili | 2017 | World Journal of Hepatology2017，9，36： | 1 |
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