|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 2 | Forest floor water content dynamics in a Douglas fir stand 显示文摘 | Schaap M G Bouten W Verstraten J M | 1997 | Journal of Hydrology1997，201，： | 1 |
| 3 | The Theory and Practice of Branch Autonomy显示文摘 | D G Sprugel T M Hinckley W Schaap | 1991 | Annual Review of Ecology and Systematics1991，，： | 1 |
| 4 | Isolation of expressed sequence tags of Agaricus bisporus and their assignment to chromosomes 显示文摘 | Sonnerberg A S de Groot P W Schaap P J | 1996 | Appl Environ Microbiol1996，62，12： | 1 |
| 5 | The need for ammonia abatement with respect to secondary PM reductions in Europe显示文摘 | Erisman J W Schaap M | 2004 | Environmental Pollution2004，129，1： | 1 |
| 6 | Forest floor evaporation in a dense Douglas fir stand显示文摘 | Schaap M G Bouten W | 1997 | Journal of Hydrology1997，193，： | 1 |
| 7 | Modeling water retention curves of sandy soils using neural networks显示文摘 | Schaap M G Bouten W | 1996 | Water Resources Research1996，32，： | 1 |
| 8 | The need for ammonia abatement with respect to secondary PM reductions in Europe 显示文摘 | Erisman J W Schaap M | 2004 | Environ Pollut2004，129，1： | 1 |
| 9 | The need for ammonia abatement with respect to secondary PM reductions in Europe 显示文摘 | Erisman J W Schaap M | 2003 | Environmental Pollution2003，129，1： | 1 |
| 10 | Forest floor evaporation in a dense Douglas fir stand显示文摘 | Schaap MG Bouten W | 1997 | Journal of Hydrology1997，193，： | 1 |
| 11 | Modeling water retention curves of sandy soils using neural networks显示文摘 | Schaap M G Bouten W | 1996 | Water Resources Research1996，32，： | 1 |
| 12 | The need for ammonia abatement with respect to secondary PM reductions in Europe显示文摘 | Erisman J W Schaap M | 2004 | Environ Pollut2004，129，1： | 1 |
| 13 | The theory and practice of branch autonomy显示文摘 | SPRUGEL D G HINCKLEY T M SCHAAP W | 1991 | Annual Review of Ecology and Systamics1991，22，： | 1 |
| 14 | The theory and practice of branch autonomy显示文摘 | Sprugel D G Hinekley T M Schaap W | 1991 | Ann Rev Ecosyst1991，22，： | 1 |
| 15 | The need for ammonia abatement with respect to secondary PM reductions in Europe显示文摘 | Erisman J W Schaap M | 2004 | Environ- mental Pollution2004，129，1： | 1 |
| 16 | B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation显示文摘 | Hobo W Norde WJ Schaap N | | 0，，： | 1 |
| 17 | The need for ammonia abatement with respect tosecondary PM reductions in Europe显示文摘 | Erisman J W Schaap M | 2004 | Environmental Pollution2004，129，： | 1 |
| 18 | Isolation of developmentally regulated genes from the edible mushroom Agaricus bisporus显示文摘 | De Groot P W J Schaap P J Van Griensven L J L D | 1997 | Microbiology1997，143，： | 1 |
| 19 | The theory and practice of branch autonomy 显示文摘 | Sprugel D G Hinckley T M Schaap W | 1991 | Annual Review of Ecology and Systematics1991，22，： | 1 |
| 20 | The theory and practice of branch autonomy显示文摘 | Sprugel D G Hinckley T M Schaap W | 1991 | Ann Rev Ecol Syst1991，22，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员