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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Role of MGST1 in reactive intermediate-induced injury显示文摘Microsomal glutathione transferase (MGST1, EC 2.5.1.18) is a membrane bound glutathione transferase extensively studied for its ability to detoxify reactive intermediates, including metabolic electrophile intermediates and lipophilic hydroperoxides through its glutathione dependent transferase and peroxidase activities. It is expressed in high amounts in the liver, located both in the endoplasmic reticulum and the inner and outer mitochondrial membranes. This enzyme is activated by oxidative stress. Binding of GSH and modification of cysteine 49 (the oxidative stress sensor) has been shown to increase activation and induce conformational changes in the enzyme. These changes have either been shown to enhance the protective effect ascribed to this enzyme or have been shown to contribute to cell death through mitochondrial permeability transition pore formation. The purpose of this review is to elucidate how one enzyme found in two places in the cell subjected to the same conditions of oxidative stress could both help protect against and contribute to reactive oxygen species-induced liver injury. | Courtney S Schaffert | 2011 | World Journal of Gastroenterology2011，17，20： | 3 |
| 3 | Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor recep- tor leads to greater anti-tumor activity in pancreatic cancer 显示文摘 | Ali S Banerjee S Schaffert JM | 2010 | J Cell Biochem2010，110，1： | 1 |
| 4 | Click chemistry for high-density biofunctionalization of mesoporous silica 显示文摘 | Schlossbauer A Schaffert D Kecht J | 2008 | J Am Chem Soc2008，130，12： | 1 |
| 5 | Palmitate-induced apoptosis can occur through a ceramide-independent pathway显示文摘 | Listenberger L L Ory D S Schaffert J E | 2001 | J Biol Chem2001，276，14： | 1 |
| 6 | Disconnectingthe yin and yang relation of epidermal growth factor re-ceptor (EGFR) -mediated delivery: a fully synthetic,EGFR-targeted gene transfer system avoiding receptor ac-tivation 显示文摘 | Schafer A Pahnke A SchafFert D | 2011 | Hum Gene Ther2011，22，12： | 1 |
| 7 | 显示文摘 | Militz H Schaffert S Peters B C | 2011 | Wood Science and Technology2011，45，3： | 1 |
| 8 | Dual-targeted polyplexes : One step towards a synthetic virus for cancer gene therapy 显示文摘 | Nie Y Schaffert D Rodl W | 2011 | Journal Controlled Release2011，152，： | 1 |
| 9 | Synthesis of polyethylenimine-based nanocarriers for systemic tumor targeting of nucleic acids 显示文摘 | Rodl W Schaffert D Wagner E | 2013 | Methods Mol Biol2013，948，： | 1 |
| 10 | IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy显示文摘 | Mike W. Helms Jennifer A. Prescher Yu-An Cao Steven Schaffert Christopher H. Contag | 2010 | Cancer Immunology Immunotherapy2010，，9： | 1 |
| 11 | Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis显示文摘 | Duryee MJ Klassen LW Schaffert CS | 2010 | Free Radic Biol Med2010，49，10： | 1 |
| 12 | Prospects for using conventional techniques and molecular biological tools to enhanee performanee of orphan crop plants on soils low in available phosphorus显示文摘 | Hash C T Schaffert R E Peacock J M | 2002 | Plant and Soil2002，245，： | 1 |
| 13 | IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy显示文摘 | Mike W. Helms Jennifer A. Prescher Yu-An Cao Steven Schaffert Christopher H. Contag | 2010 | Cancer Immunology, Immunotherapy2010，，9： | 1 |
| 14 | Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis显示文摘 | Duryee MJ Klassen LW Schaffert CS | 2010 | Free Radic Biol Med2010，49，10： | 1 |
| 15 | Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis显示文摘 | Schaffert C S Duryee M J Bennett R G | 2010 | Am J Physiol:Gastrointestinal Liver Physiol2010，299，3： | 1 |
| 16 | On the way towards Personal Learning Environments: Seven crucial aspects显示文摘 | Schaffert S Hilzensauer W | 2005 | Elearning papers2005，9，2： | 1 |
| 17 | Soil aluminium effects on uptake,influx,and transport of nutrients in sorghum genotypes显示文摘 | Baligar V C Schaffert R E Dos Santos H L | 1993 | Plant Soil1993，150，： | 1 |
| 18 | Regulation of immune responses and tolerance : the microRNA perspective 显示文摘 | Chen CZ Schaffert S Fragoso R | 2013 | Immu- nol Rev2013，253，1： | 1 |
| 19 | Distributed control applications within sensor networks 显示文摘 | Sinopoli B Schaffert L Sastry S | 2003 | Proceedings of the IEEE2003，91，8： | 1 |
| 20 | Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1显示文摘 | Fragoso R Mao T Wang S Schaffert S Gong X Yue S | | 0，，： | 1 |
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