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| 1 | Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images显示文摘Super-resolution structured illumination microscopy(SR-SIM) provides an up to twofold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high-quality SR-SIM images critically depends on patterned illumination with high modulation contrast. Noisy raw image data(e.g., as a result of low excitation power or low exposure time), result in reconstruction artifacts. Here, we demonstrate deep-learning based SR-SIM image denoising that results in high-quality reconstructed images. A residual encoding–decoding convolutional neural network(RED-Net) was used to successfully denoise computationally reconstructed noisy SR-SIM images.We also demonstrate the end-to-end deep-learning based denoising and reconstruction of raw SIM images into high-resolution SR-SIM images. Both image reconstruction methods prove to be very robust against image reconstruction artifacts and generalize very well across various noise levels. The combination of computational image reconstruction and subsequent denoising via RED-Net shows very robust performance during inference after training even if the microscope settings change. | ZAFRAN HUSSAIN SHAH MARCEL MÜLLER TUNG-CHENG WANG PHILIP MAURICE SCHEIDIG AXEL SCHNEIDER MARK SCHÜTTPELZ THOMAS HUSER WOLFRAM SCHENCK | 2021 | Photonics Research2021，9，5： | 11 |
| 2 | NEJM:治疗性低温不能改善惊厥性癫痫持续状态的预后显示文摘惊厥性癫痫持续状态是最具挑战的威胁生命的神经系统急症,应迅速给予抗癫痫药物治疗,并根据对临床和脑电图的反应调整治疗方案。其住院死亡率大约为20%,难治性癫痫持续状态死亡率高达40%。癫痫持续状态的功能缺损可能是由其对皮质神经元的作用或原发病对大脑的损害造成的。在前瞻性多中心研究中,90 d时50%收住ICU的惊厥性癫痫持续状态幸存者残留功能缺损。不良预后独立危险因素包括老年、运动性痫性发作的持续时间、 | 杨中华 Legriel S Lemiale V Schenck M | 2017 | 中国卒中杂志2017，12，4： | 2 |
| 3 | 显示文摘 | Green M L Schenck P K | 2009 | Microeleetronic Engi- neering2009，86，： | 1 |
| 4 | Intravenous administration of vitamin C in the treatment of herpetic neuralgia:two case reports显示文摘 | Schencking M Sandholzer H Frese T | | 0，，： | 1 |
| 5 | Insights from studying human sleep disorders显示文摘 | MAHOWALD M W SCHENCK C H | 2005 | Nature2005，437，： | 1 |
| 6 | A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis of the hip or knee:protocol of a prospective randomised controlled clinical trial显示文摘 | Schencking M Otto A Deutsch T | | 0，，： | 1 |
| 7 | Bactarial fruit rat of watermelon in Florida显示文摘 | Crall J M Schenck N C | 1969 | Plant Disease Report1969，53，： | 1 |
| 8 | 查看详情显示文摘 | Anastassiades M Lehotay S J Stajnbaher D Schenck F J | | 0，，02： | 1 |
| 9 | Bacterial fruit rot of watermelon in Florida 显示文摘 | Crall J M Schenck N C | 1969 | Plant Disease Report1969，53，： | 1 |
| 10 | Nanoscale Atoms in Solid- State Chemistry 显示文摘 | Roy X Lee C H Crowther A C Schenck C L Besara T Lalancette R A Siegrist T Stephens P W Brus L E Kim P Steigerwald M L Nuckolls C | 2013 | Science2013，，341： | 1 |
| 11 | A high- throughput thermoelectric power- factor screening tool for rapid construction of thermoelectric property diagrams显示文摘 | Otani M Lowhorn N D Schenck P K | 2007 | Applied Physics Letters2007，91，13： | 1 |
| 12 | Comparison of magnesium sulfate and sodium sulfate for removal of water from pesticide extracts of foods显示文摘 | Schenck F J Callery P Gannett P M | 2002 | Journal of aoac international2002，85，5： | 1 |
| 13 | Fast and easy multiresidue method employing acetonitrile extraction/partitioning and 'dispersive solid-phase extraction' for the determination of pesticide residues in produce显示文摘 | ANASTASSIADES M LEHOTAY S J STAJNBAHER D SCHENCK F J | 2003 | J AOAC Int2003，86，9： | 1 |
| 14 | Bacterial fruit rot of watermelon in Florida 显示文摘 | Crall J M Schenck N C | 1969 | Plant Disease Report1969，53，： | 1 |
| 15 | Effect of body weight on osteopenia in ovariectomized rats显示文摘 | Wronski TJ Schenck PA Cintron M | | 0，，03： | 1 |
| 16 | IL-2 gene expression and NF-KB activation through CD28 requires reactive oxygen production by 5-lipoxygenase显示文摘 | Los M Schenck H Hexel K | 1995 | EMBO J1995，14，： | 1 |
| 17 | Fast and easy multiresidue method employing acetonitrile extraction/partitioning and 'dispersive solid- phase extraction' for the determination of pesticide residues in produce 显示文摘 | Anastassiades M Lehotay S J Stajnbaher D Schenck F J | 2003 | Journal of AOAC International2003，86，2： | 1 |
| 18 | Genetic di- versity and relationships in native Hawa//an Sac-charum offwinarum sugarcane 显示文摘 | Schenck S Crepeau M W Wu K K | 2004 | J Hered2004，95，4： | 1 |
| 19 | Deci-phering Igneous and Metamorphic Events in High-grade Rocks of the Wilmington Complex,Delaware:Morphology,Cathodoluminescence and Backscattered Electron Zoning,and SHRIMP U-Pb Geochronology of Zircon and Monazite显示文摘 | Aleinikoff J N Schenck W S Plank M O | 2006 | Geological Society of America Bulletin2006，118，12： | 1 |
| 20 | Distinct cytogenetic alternations in squamous intraepithelial lesions of the cervix revealed by laser-assisted microdissection and comparative genomic hybridization显示文摘 | Zitzelsberger H Schenck U | 1998 | Cancer1998，84，6： | 1 |
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