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402篇 您的检索式：作者名="Schink"

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	题名	作者	年代	出处	被引量
1	Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans.	Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier	2018	Bone Research2018，6，1：	5
2	Comparison of Aerobic Methanotrophic Communities in Littoral and Profundal Sediments of Lake Constance by a Molecular Approach显示文摘	Monali Rahalkar and Bernhard Schink	2007	Applied and Environmental Microbiology2007，73，13：	1
3	Self-efficacy of children and adolescents:A meta-analysis显示文摘	Holden G Moncher M.S Schinke S.P Barker K.M		0，，66：	1
4	Inhibition of methanogenesis by ethylene and other unsaturated hydrocarbons显示文摘	Schink B	1985	FEMS Microbiology Ecology1985，31，：	1
5	Cloning and targeted deletion of the mouse fetuin gene显示文摘	Jabnen-Dechent W Schinke T Trindl A	1997	J Biol Chem1997，272，31：	1
6	Anaerobic nitrate dependent microbial oxidation of ferrousiron显示文摘	Straub K L Benz M Schink B	1996	Appl Environ Microbiol1996，62，4：	1
7	Phosphite oxidation by sulphate reduction显示文摘	Schink B Friedrich M	2000	Nature2000，406，7：	1
8	The osteoblast:A sophisticated fibroblast under central surveil ance显示文摘	Ducy P Schinke T Karsenty G		0，，5484：	1
9	Rituximab for the second-and third-line therapy of idiopathic membranous nephropathy:a prospective single center study using a new treatment strategy显示文摘	Busch M Rüster C Schink(o)the C		0，，02：	1
10	Head-tohead comparison of multislice computed tomography and exercise electrocardiography for diagnosis of coronary artery disease显示文摘	Dewey M Dubel H P Schink T		0，，20：	1
11	Eeophysiology and the energetic benefit of mixotrophie Fe(Ⅱ) oxidation by various strains of nitrate-reducing bacteria显示文摘	Muehe EM Gerhardt S Schink B	2009	FEMS Microbiology Ecology2009，70，3：	1
12	Automated Evaluation of Material Parameters of viscoplastic constitutive equations显示文摘	Schwertel J Schinke B	1996	Journal of Engineering Materials and Technology1996，118，：	1
13	Syntrophic butyrate and propionate oxidation processes : from genomes to reaction mechanisms 显示文摘	MULLER N WROM P SCHINK B et aI	2010	Environmental Microbiology Report2010，2，4：	1
14	Cartilage formation and calcification in arteries of mice lacking matrix Gla protein显示文摘	EI Maadawy S Kaartinen M T Schinke T	2003	Connect Tissue Res2003，44，1：	1
15	Cloning and targeted deletion of the mouse fetuin gene 显示文摘	Jahnen-Dechent W Schinke T Trindl A	1997	J Biol Chem1997，272，31：	1
16	Primary treatment of metastatic high-risk gestational trophoblastic neoplasia with EMA-CO chemotherapy显示文摘	Lurain JR Singh DK Schink JC	2006	J Reprod Med2006，51，10：	1
17	Role of surgery in the management of high-risk gestational trophoblastic neoplasia显示文摘	Lurain JR Singh DK Schink JC	2006	J Reprod Med2006，51，10：	1
18	Bacterial metabolism:phosphite oxidation by sulphate reduction显示文摘	Schink B Friedrech M	2000	Nature2000，406，6791：	1
19	Inactivation of F2 virus with ferrate (Ⅵ ) 显示文摘	SCHINK T WAITE T D	1980	Water Research1980，14，：	1
20	The impact of anaemia and kidney function in congestive heart failure and preserved systolic function显示文摘	Philipp S Ollmann H Schink T	2005	Nephrol Dial Transplant2005，20，5：	1

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