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| 1 | Prevalence and knowledge of hepatitis C in a middle-aged population,Dunedin,New Zealand显示文摘AIM:To determine the prevalence of infection with hepatitis C virus(HCV) in those most at risk of advanced liver disease and to identify gaps in knowledge of HCV.METHODS: Questionnaires were mailed to randomly selected residents aged 40-59 to assess the extent of their general knowledge about HCV. The questionnaire assessed demographics, the extent of general knowledge about viral hepatitis, potential risks for infection and the prevalence of risk factors associated with increased progression of liver fibrosis. Anonymised residual laboratory blood samples from 40-59 years old people from Dunedin taken in hospital or in the community, were tested for HCV antibodies and alanine transaminase(ALT), aspartate transaminase(AST), gamma-glutamyl transpeptidase(GGT). Linear regression was performed to examine whether the demographics sex, age, socio-economic status, qualification level and occupation sector(categorical variables) were predictors of level of general knowledge about hepatitis. For the demographics that werefound to be significant predictors of score outcome, multiple regression analysis was used to determine independent effects. χ2 tests were used to compare our selected sample and our responder population demographics, to the demographics of the entire 40-59 years old population in Dunedin using the 2006 NZ census data. Exact confidence intervals for the proportion positive for HCV and HBV were calculated using the binomial distribution.RESULTS: The response rate to the mailed questionnaire was 431/1400(30.8%). On average 59.4% questions were answered correctly. Predictors for higher scores, indicating greater knowledge about symptoms and transmission included sex(female, P < 0.01), higher level of qualification(P < 0.000) and occupation sector(P < 0.000). Sharing intravenous drug utensils was a known risk factor for disease transmission(94.4%), but the sharing of common household items such as a toothbrush was not. 93% of the population were unaware that HCV infection can be asymptomatic. 25% did not know that treatment was available in New Zealand and of those who did know, only 40% assumed it was funded. Six hundred and eighty-two residual anonymised blood samples were tested for HCV antibodies, ALT, AST and GGT. The prevalence for HCV was 4.01%, 95%CI: 2.6%-5.8%. Liver function tests were not useful for identifying likelyhood of HCV infection.CONCLUSION: Prevalence of HCV in our population is high, and the majority have limited knowledge of HCV and its treatment. | Jane Vermunt Margaret Fraser Peter Herbison Anna Wiles Martin Schlup Michael Schultz | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Enzymes degrading bacterial chemotactic F-met peptidesin human ileal and colonic mucosa 显示文摘 | Chadwick V S Schlup M M Cooper B T | 1990 | J Gastroenterol Hepatol1990，5，4： | 1 |
| 3 | Fractal analysis of polymeric and particulate titania aerogels by adsorption显示文摘 | Meng F Schlup J R Fan L T | 1997 | Chem Mater1997，9，： | 1 |
| 4 | Efficient single - frequency pulsed periodically poled lithium niobate optical parametric oscillator显示文摘 | Schlup P Butterworth D S McKinnie J T | 1998 | Optics Communications1998，154，4： | 1 |
| 5 | Efficient, single frequency, high repetition rate, PPLN OPO pumped by a prelase Q - switched diode - pumped Nd: YAG laser显示文摘 | G.W. Baxter P. Schlup I.T. McKinnie | | 0，，： | 1 |
| 6 | Nanoscale metal oxide particles/clusters as chemical reagents, synthesis and properties of ultrahigh surface area magnesium hydroxide and magnesium oxide 显示文摘 | Utamapanya S Klabunde K J Schlup J R | 1991 | Chemistry of Materials1991，3，1： | 1 |
| 7 | Nanoscale metal oxide particles/clusters as chemical reagents:Synthesis and properties of ultrahigh surface area magnesium hydroxide and magnesium oxide 显示文摘 | Uhamapanya S Klabunde K J Schlup J R | 1991 | Chem Mater1991，3，： | 1 |
| 8 | Nanocrystalline materials by mechanical alloying 显示文摘 | Grewe H | 1990 | Int J Materials and Product Technology1990，5，3： | 1 |
| 9 | Fractal analysis of polymeric and particulate titania aerogels by adsorption显示文摘 | MENG F SCHLUP J R FAN L T | | 0，，： | 1 |
| 10 | Monitoring the process of curing of epoxy/graphite fiber composites with a recurrent neural network as a soft sensor 显示文摘 | Su H B Fan L T Schlup J R | 1998 | Engineering Applications of Artificial Intelligence1998，11，2： | 1 |
| 11 | 显示文摘 | Utamapanya S Klabunde K J Schlup J R | 1991 | Chem Mater1991，3，： | 1 |
| 12 | A comparative study of surface fractality between polymeric and particulate titania aerogels显示文摘 | MENG P SCHLUP J R FAN L T | 1998 | J Non-Cryst Solids1998，197，： | 1 |
| 13 | Single-mode, singly resonant, pulsed periodically poled lithium niobate optical parametric oscillator显示文摘 | P Schlup I T McKinnie S D Butterworth | 1999 | Appl Opt1999，38，36： | 1 |
| 14 | Fourier transform infrared spectroscopic study of predeposition reactions in metalloorganic chemical vapor deposition of gallium nitride显示文摘 | Sywe B S Schlup J R Edgar J H | 1991 | Chemistry of Materials1991，3，4： | 1 |
| 15 | Appl Phys显示文摘 | Christodoulou C N Schlup J J | 1987 | 61 (8):37601987，61，8： | 1 |
| 16 | Attosecond angular streaking显示文摘 | Eckle Petrissa Smolarski Mathias Schlup Philip Biegert Jens Staudte André Sch?ffler Markus Muller Harm G D?rner Reinhard Keller Ursula | 2008 | Nature Physics2008，，7： | 1 |
| 17 | Quality control:all application of the CUSUM显示文摘 | WILLIAMS S M PPRRY B R SCHLUP M M T | 1992 | BMJ1992，304，： | 1 |
| 18 | Measurements of unsaturated vitamin B12-binding capacity and myeloperoxidase as indices of severity of acute inflammation in serial colonoscopy biopsy specimens from patients with inflammatory bowel disease显示文摘 | Schlup MM Feny DM | 1990 | Scand J Gastroenterol1990，25，12： | 1 |
| 19 | Nanoscalemetal oxide particles/clusters as chemical reagents: Synthesisand properties of ultrahigh surface area magnesium hydroxideand magnesium oxide显示文摘 | UTAMAPANYA S KLABUNDE K J SCHLUP J R | 1991 | Chemistry of Materials1991，3，1： | 1 |
| 20 | Nanocrystalline materials by mechanical alloying显示文摘 | SCHLUP W GREWE H | 1990 | Int J Materials and Product Technology1990，5，3： | 1 |
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