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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | 轿车和载货车用发动机的两级可调增压系统显示文摘当前的技术现状是,带有可变涡轮几何截面的涡轮增压器装在轿车和部分载货车用柴油机上后,一级增压技术的极限就显而易见了。提高标定功率大多会使起动扭矩恶化,为了解决这个难题,介绍一种由Borg-Warner公司研发的两级可调增压系统(R2S)。 | Chiristmann R | 2006 | 国外内燃机2006，38，1： | 3 |
| 3 | 未来内燃机用机械式全可变气门升程控制系统显示文摘优化换气和燃烧过程,以获得更好的性能和排放,最重要的是充分挖掘内燃机效能的潜力。提升内燃机潜力的唯一途径是使用无级可变进气门升程及可变升程持续期的气门机构,以实现无节气门负荷控制。Kolbenschmidt Pierburg公司选择了由Entec Consulting公司开发的Univalve系统,并获得这种新系统的授权。在双方共同努力下,目前正在对Univalve系统进行大批量投产前的最后开发。 | Flierl R Schmitt S Kleinert G Esch H-J Dismon H 张然治 | 2013 | 国外内燃机2013，45，2： | 2 |
| 4 | Properties and struc- tures of tin borophosphate glasses显示文摘 | Lira J W Schmitt M L Brow R K | 2010 | Journal of Non-Crystal- line Solids2010，356，： | 1 |
| 5 | Quality of life issue in lung cancer new symptom, man managerment strategies显示文摘 | Schmitt R | 1993 | Chest1993，103，1： | 1 |
| 6 | Resistance to disinfectants in epidemiologically defined clinical isolates of Acinetobacter baumannii 显示文摘 | Wisplinghoff H Schmitt R Wohrmann A | 2007 | J Hosp Infect2007，66，2： | 1 |
| 7 | Multi - slice spiral CT of the coronary arteries: clear vascular imaging using standard software显示文摘 | Frohner S Brunn J | 2001 | Rontgenpraxis2001，54，4： | 1 |
| 8 | Decreased plasma concentration of brain natrluretic peptide as a potential indicator of cardiac recovery in patients supported by mechanical circulatory assist systems 显示文摘 | Sodian R Loebe M Schmitt C | 2001 | J Am Coil Cardiol2001，38，： | 1 |
| 9 | Exchanging catheters over a single transseptal sheath during left atrial ablation is associated with a higher risk for silent cerebral events 显示文摘 | Deneke T Nentwich K Schmitt R | 2014 | Indian Pacing Electrophysiol J2014，14，5： | 1 |
| 10 | Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non-Hodgkin lymphoma显示文摘 | Schmitt M Trenschel R Sayer H G | 2014 | Mol Clin Oncol2014，2，5： | 1 |
| 11 | Photosynthetic capacity and nitrogen use efficiency of maize, wheat and rice, a comparison between C3 and C4 photosynthetic显示文摘 | Schmitt M R Ewards G E | 1981 | Joumal of Experimental Botany1981，32，： | 1 |
| 12 | The frequency and tim- ing of epileptiform activity on continuous electroencephalo- gram in comatose post cardiac arrest syndrome? patients treated with therapeutic hypothermia 显示文摘 | Mani R Schmitt S E Mazer M | 2012 | Resuscitation2012，83，7： | 1 |
| 13 | Immune re- sponses to WT1 in patients with AML or MDS after chemotherapy and allogeneie stem cell transplantation显示文摘 | Casalegno-Gardufio R Schmitt A Spitsehak A | 2016 | Int J Cancer2016，138，7： | 1 |
| 14 | The effects of plant extracts of Reynoutria sachalinensis on powdery mildew development and leaf physiology of long English cucumber显示文摘 | Daayf F Schmitt A Belanger R | 1995 | Plant Disease1995，79，： | 1 |
| 15 | Scaphoid fractures: diagnosis, classification and therapy 显示文摘 | Krimmer H Schmitt R Herbert T | 2000 | Unfallchirurg2000，103，： | 1 |
| 16 | Thin film rheology and tribology of confined polymer melts contrasts with bulk properties 显示文摘 | Luengo G Schmitt FJ Hill R | 1997 | Macromolecules1997，30，8： | 1 |
| 17 | Effects of acute hypoxia tests on blood markers in high level endurance athletes显示文摘 | Mounier R Pialoux V Schmitt L | 2009 | Eur J Appl Physio12009，106，5： | 1 |
| 18 | Decreased plasma concentration of brain natriuretic peptide as a potential indicator of cardiac recovery in patients supported by mechanical circulatory assist systems 显示文摘 | Sodian R Loebe M Schmitt C | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 19 | Bcr-ABL maintains resistance of chromic myelogeneous leukemia cells to apoptotie cell death显示文摘 | Me Gahon A Bissonnette R Schmitt M | 1994 | Blood1994，83，： | 1 |
| 20 | Intraosseous access for neonatal and newborn resuscitation in the National Park Service (NPS) 显示文摘 | Schmitt E R Stroh G Shalit M | 2011 | Prehosp Disaster Med2011，26，3： | 1 |
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