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114篇 您的检索式：作者名="Schmuck"

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	题名	作者	年代	出处	被引量
1	Tumor–stromal cross-talk modulating the therapeutic response in pancreatic cancer显示文摘Background: Pancreatic ductal adenocarcinoma(PDAC) is a highly malignant solid tumor with a dismal prognosis. The stroma component makes up to 90% of the tumor mass and is thought to be one of the main reasons for the tumor's high chemoresistance. Cancer associated fibroblasts(CAFs) have previously been identified to be the key stromal players. This is the first time we provide detailed in vitro experiments investigating tumor–stromal interactions when exposed to three well-known chemotherapeutic agents. Methods: Monocultures, indirect and direct co-cultures of two PDAC cell lines(AsPC and Panc-1) and six primary patients derived CAFs were treated with gemcitabine, nab-paclitaxel and the γ-secretaseinhibitor(GSI) DAPT. The cell viability of each component was measured with XTT. Finally, IL-6 concentrations of the supernatants were analyzed. Results: On the contrary to PDAC cell lines, CAF monocultures hardly responded to any treatment which suggested that stroma(CAFs) itself is more resistant to standard chemo-treatments than the epithelial cancer cells. Moreover, only a weak chemotherapeutic response was observed in direct co-cultures of cancer cells with CAFs. A change in the morphology of direct co-cultures was accompanied with the chemoresistance. CAFs were observed to build cage-like structures around agglomerates of tumor cells. High levels of IL-6 were also associated with a reduced response to therapy. Indirect co-cultures make the tumor–stromal interaction more complex. Conclusions: CAFs are highly chemoresistant. Direct cell–cell contact and high levels of IL-6 correlate with a high chemoresistance.	Christopher C.M.Neumann Ellen von Horschelmann Anja Reutzel-Selke Elisabeth Seidel Igor Maximilian Sauer Johann Pratschke Marcus Bahra Rosa Bianca Schmuck	2018	Hepatobiliary & Pancreatic Diseases International2018，17，5：	2
2	Analyzed dietary intakes,plasma concentrations of zinc,copper,and selenium,and related antioxidant benzyme activities in hospitalized elderly women显示文摘	Schmuck A Roussel AM Arnaud J	1996	J Am Coll Nutr1996，15，5：	1
3	Oxidative stress in rat cortical neurons and astrocytes induced by paraquat in vitro显示文摘	Schmuck G Rohrdanz E Tran-Thi QH	2002	Neurotox Res2002，4，1：	1
4	Rat cortical neuron cultures: an in vitro model for differentiating mechanisms of chemically induced neurotoxicity显示文摘	Schmuck G Ahr I-IJ Schluter G	2000	In Vitr Mol Toxieol2000，13，：	1
5	Demonstration of an SOA-assisted open metro-access infrastructure for heterogeneous services显示文摘	Schmuck H Bonk R Poehlmann W	2014	Optics Express2014，22，1：	1
6	Molecular whole -body cancer staging using positron emission tomography: consequences for therapeutic management and metabolic radiation treatment planning 显示文摘	Schmucking M Baum RP Griesinger F	2003	Recent Results Cancer Res2003，162，：	1
7	Stereotactic radiation treatment planning and follow-up studies involving fused multimodality imaging显示文摘	Hamm KD Surber G Schmucking M	2004	J Neurosurg2004，101，3：	1
8	Comparison of optical millmetre-wave system concept s with regard to chromatic dispersion显示文摘	Schmuck H	1995	Electronics Letters1995，31，21：	1
9	Polymer electrolyte forlithium batteries based on photochemically crosslinked poly(ethylene oxide)and ionic liquid显示文摘	Rupp B Schmuck M Balducci A	2008	Eur Polym J2008，44，9：	1
10	Characterization of the monomethylarsonate reductase and dehydroascorbatereduc- tase activities of omega class glutathione transferasevariants : im- plications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases 显示文摘	Schmuck EM Board PG Whitbread AK	2005	Pharmacogenetics and Genomics2005，15，7：	1
11	Dispersion effects in optical millimeter-wave systems using self-heterodyne method for trans- port and generation 显示文摘	HOFSTETTER R SCHMUCK H HEIDEMANN R	1995	IEEE Transactions on Microwave Theory and Tech- niques1995，43，9：	1
12	Nglycosylation of CD97 within the EGF domains is crucial for epitope accessibility in normal and malignant cells as well as CD55 ligand binding 显示文摘	Wobus M Vogel B Schmucking E	2004	Int J Cancer2004，112，5：	1
13	Characterization of the monomethylarsonate reduetase and dehydroascorbate reduetase activities of Omega class glutathione transferase variants: implica- tions for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases 显示文摘	Schmuck EM Board PG Whitbread AK	2005	Pharmacogenet Genomics2005，15，7：	1
14	Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to Arsenic trioxide and other cytotoxic drugs 显示文摘	Schmuck E Cappello J Coggan M	2008	Int J Biochem Cell Biol2008，40，11：	1
15	Characterization of the monomethylarsonate reductase and dehydroascorbate re- ductase activities of omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases 显示文摘	Schmuck EM Board PG Whitbread AK	2005	Pharmacogenet Ge- nomics2005，15，7：	1
16	Aldosterone regulates vascular reactivity:short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation显示文摘	Liu SL Schmuck S Chorazcyzewski JZ	2003	Circulation2003，108，19：	1
17	Characterizing the learning curve for laparoscopic radical hysterectomy: buddy operating as a technique for accelerating skill acquisition显示文摘	Reade C Hauspy J Schmuck M L	2011	Int J Gynecol Cancer2011，21，5：	1
18	Assessing the effects of land use changes on floods in the Meuse and Oder catchment显示文摘	DE ROO A ODIJK M SCHMUCK G	2001	Physics and Chemistry of the Earth (B)2001，26，78：	1
19	Side chain selective binding of N-acetyl-a-amino acid carboxylates by a 2-(guanidiniocarbonyl)pyrrole receptor in aqueous solvents 显示文摘	Schmuck C	1999	Chem Commun1999，，9：	1
20	Carboxylate binding by 2-(guanidiniocarbonyl)pyrrole receptors in aqueous solvents: improving the binding properties of guanidinium cations through additional hydrogen bonds 显示文摘	Schmuck C	2000	Chem Eur J2000，6，4：	1

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