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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Early clinical worsening in patients with TIA or minor stroke: The Austrian Stroke Unit Registry显示文摘 | J Ferrari M Knoflach S Kiechl J Willeit S Schnabl L Seyfang W Lang | 2010 | Neurology2010，，2： | 2 |
| 4 | The ALDH gene superfamily of Arabidopsis显示文摘 | Kirch H H Bartels D Wei Y Schnable P S Wood A J | | 0，，： | 1 |
| 5 | Characterization of the dominant mutant amylose extender (Ae-5180) maize starch显示文摘 | Jane J Schnable P | 1995 | Cereal chemistry1995，72，5： | 1 |
| 6 | Characterization of the dominant mutant amyloseextender (Ae1-5180) maize starch显示文摘 | JANE J SCHNABLE P | 1995 | Cereal Chemistry1995，72，5： | 1 |
| 7 | Role of TLR9 in hepatic stellate cells and experimental liver fibrosis 显示文摘 | Ggbele E M/ihlbauer M Dorn C Weiss TS Froh M Schnabl B Wiest R Sch61merich J Obermeier F Hellerbrand C | 2008 | Biochem Biophys Res Commun2008，376，2： | 1 |
| 8 | The role of Smad3 in mediating mouse hepatic steUate cell activation 显示文摘 | SCHNABL B KWEON Y O FREDERICK J P | 2001 | Hepatology2001，34，1： | 1 |
| 9 | Portable LED-Array VIS-NIR Spectrophotometer/ Nephelometer显示文摘 | Schnable J G Grochowski P J Wilhelm L | 1998 | Field Analytical Chemistry and Technology1998，2，1： | 1 |
| 10 | Microsatellite variations of elite setaria varieties released during last six decades in China显示文摘 | Jia G Liu X Schnable J C | 2015 | PLoS One2015，10，01： | 1 |
| 11 | Genome-wide patterns of genetic variation among elite maize inbred lines显示文摘 | Lai J Li R Xu X Jin W. Xu M. Zhao H. Xiang Z. Song W. Ying K. Zhang M. Jiao Y. Ni P. Zhang J. Li D. Guo X. Ye K. Jian M. Wang B. Zheng H. Liang H. Zhang X. Wang S. Chen S. Li J. Fu Y. Springer N.M. Yang H. Wang J. Dai J. Schnable P.S. Wang J | | 0，，11： | 1 |
| 12 | Identification of the host deterrmnant of two prolate-headed phages infecting Lactococcus lactis显示文摘 | STUER-LAURIDSEN B JANZEN T SCHNABL J | 2003 | Virology2003，309，1： | 1 |
| 13 | Characterization of the dominant mutant amylose extender (Ae-5180) maize starch显示文摘 | Kasemsuwan T Jane J Schnable P | 1995 | Cereal chemistry1995，72，5： | 1 |
| 14 | Active middle ear implantation in elderly people: a retrospective study显示文摘 | Wolf-Magele A Schnabl J Woellner T | 2011 | Otoi Neurotol2011，32，5： | 1 |
| 15 | Following tetraploidy in maize, a short deletion mec- hanism removed genes preferentially from one of the two homologs显示文摘 | Woodhouse M R Schnable J C Pedersen B S | 2010 | Plos Biology2010，8，10： | 1 |
| 16 | The roles of aldehyde dehydrogenases (ALDHs) in the PDH bypass of Arabidopsis显示文摘 | Wei Y L Lin M Oliver D J Schnable P S | | 0，，： | 1 |
| 17 | Cloning and characterization of CER2, an Arabidopsis gene that affects cuticular wax accumulation 显示文摘 | Xia Y Nikolau B J Schnable PS | 1996 | Plant Cell1996，8，： | 1 |
| 18 | Immortal activated human hepatic stellate cells generated by ectopic telomerase expression显示文摘 | Schnabl B Choi YH Olsen J C | 2002 | Lab Invest2002，82，3： | 1 |
| 19 | The role of Smad3 in mediating mouse hepatic stellate cell activation显示文摘 | SCHNABL B KWEON Y O FREDERICK J P | 2001 | Hepatology2001，34，1： | 1 |
| 20 | Cloning and characterization of the maize Anlgene显示文摘 | Bensen R J Johal G S Crane V C Tossberg J T Schnable P S Meeley R B Briggs S P | | 0，，： | 1 |
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