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| 1 | Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers显示文摘Here, we describe the use of monolayers of intestinal epithelial cells derived from intestinal organoids and transcriptomics to investigate the direct effects of dietary protein sources on epithelial function. Mechanically dissociated 3 D organoids of mouse duodenum were used to generate a polarized epithelium containing all cell types found in the tissue of origin. The organoid-derived cell monolayers were exposed to 4%(w/v) of ‘undigested(non-hydrolysed)-soluble' fraction of protein sources used as feed ingredients [soybean meal(SBM) and casein], or alternative protein sources(spray dried plasma protein, and yellow meal worm), or controls for 6 h prior to RNA isolation and transcriptomics. All protein sources altered expression of unique biological processes in the epithelial cells. Exposure of intestinal organoids to SBM downregulated expression of retinol and retinoid metabolic processes as well as cholesterol and lipid biosynthetic pathways, consistent with the reported hypotriglyceridaemic effect of soy protein in vivo. These findings support the use of intestinal organoids as models to evaluate complex interactions between dietary ingredients and the intestinal epithelium and highlights some unique host effects of alternative protein sources in animal feed and potentially human food. | Soumya K.Kar Bart van der Hee Linda M.P.Loonen Nico Taverne Johanna J.Taverne-Thiele Dirkjan Schokker Mari A.Smits Alfons J.M.Jansman Jerry M.Wells | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 3 |
| 2 | Reconstitution properties of micellar casein powder: Effects of composition and storage显示文摘 | Erix P. Schokker Jeffrey S. Church Jitendra P. Mata Elliot P. Gilbert Amirtha Puvanenthiran Punsandani Udabage | 2011 | International Dairy Journal2011，，11： | 1 |
| 3 | The shear-induced destabilization of oil-in-water emulsions using caseinate as emulsifier显示文摘 | Erix P Schokker Douglas G Dalgleish | 1998 | Colloids and Surfaces A1998，145，： | 1 |
| 4 | Corrosion Risk of Bonded,Post-tensioned ConcreteElements显示文摘 | SALAS R M SCHOKKER A J WEST J S | 2008 | PCI Journal2008，53，1： | 1 |
| 5 | Dynamic buckling of composite shells显示文摘 | Schokker A Sridharan S Kasagi A | 1996 | Computers & Structures1996，59，1： | 1 |
| 6 | The shear-induced destabilization of oil-in-water emulsions using caseinate as emulsifier显示文摘 | Schokker E P Dalgleish D G | 1998 | Colloids and Surfaces A1998，145，： | 1 |
| 7 | De- velopment, validity and responsiveness of the Clinical COPD Questionnaire显示文摘 | Van Der M01en T Willernse B W Schokker S | 2003 | Health Qual Life Outcomes2003，1，1： | 1 |
| 8 | Development, validity and responsiveness of the clinical COPD questionnaire显示文摘 | Molen T Willemse BW Schokker S | 2003 | Health Qual Life Outcomes2003，1，： | 1 |
| 9 | The shear-induced destabilization of oil in water emulsions using caseinate as emulsifier显示文摘 | Schokker E P Dalgleish D G | 1998 | Colloids and Surfaces A1998，145，： | 1 |
| 10 | Meta-analysis of chicken Salmonella infection experiments显示文摘 | Te Pas M Hulsegge I Schokker D | | 0，，01： | 1 |
| 11 | Development, Validity and Responsiveness of the Clinical COPD Ques- tionnaire显示文摘 | Molen T Willemse B W Schokker S | 2003 | Health Qual Life Outcomes2003，，28： | 1 |
| 12 | Characterization of intermediates formed during heat-induced aggregation of/3-1actoglobulin AB at neutral pH显示文摘 | Schokker EP Singh H Pinder DN | 1999 | International Dairy Journal1999，9，11： | 1 |
| 13 | Simulated field tes- ting of high performance grouts for post-tensioning 显示文摘 | Schokker A J Breen J E Kreger M E | 2002 | J Bridge Eng2002，7，2： | 1 |
| 14 | The shear-induced destabi- lization of oil-in-water emulsions using caseinate as emul- sifier 显示文摘 | Schokker E P Dalgeish D G | 1998 | Colloids and Surfaces A1998，145，： | 1 |
| 15 | Reconstitutionproperties of micellar casein powder: Effects of composition and storage显示文摘 | Schokker E P Church J S Mata J P | 2011 | International Dairy Journal2011，21，11： | 1 |
| 16 | Grouts for bonded post-tensioning in corrosive environments显示文摘 | Schokker A J Breen J E Kreger M E | 2001 | ACI Mater J2001，98，4： | 1 |
| 17 | Fluticasone or monte- lukast for preschool children with asthma-like symptoms: ran- domized controlled trial 显示文摘 | Kooi EM Schokker S Marike BH | 2008 | Pulm Pharmacol Ther2008，21，： | 1 |
| 18 | Development,validity and responsiveness of the Clinical COPD Questionnaire显示文摘 | Thys van der Molen Brigitte WM Willemse Siebrig Schokker | 2003 | Health and Quality of Life Outcomes2003，，1： | 1 |
| 19 | Long-lasting effects of early-life antibiotic treatment and routine animal handling on gut microbiota composition and immune system in pigs显示文摘 | Schokker D Zhang J Vastenhouw S A | 2015 | Plo S One2015，10，01： | 1 |
| 20 | Development, validity and responsiveness of the clinical COPD question- naire显示文摘 | Molen T Willemse BW Schokker S | 2003 | Health Qual Life Outcomes2003，，1： | 1 |
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