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| 1 | 离体肝脏常温下保存的实验研究显示文摘为了探索常温下(22℃)保存离体肝脏的可能性,本实验以HTK液为基础,氟碳乳剂为氧载体,脂肪乳剂为能量,常温下充氧持续灌注离体猪肝门静脉。定时取灌注液测量肝生化指标,观察肝细胞线粒体大小及密度。发现含氧载体灌注液中氨浓度下降,尿素浓度升高,线粒体损伤较轻;加入脂肪乳剂则能维持葡萄糖的浓度。各项指标与对照组比较差异有显著意义。说明利用氧载体(氟碳乳剂)为离体肝提供足够的氧,同时给予足够的能量(脂肪乳剂)时,离体肝脏就能在较高温度下较长时间(40小时)地维持它的主要解毒功能——摄取氨合成尿素,同时亦可维持肝细胞线粒体的稳定性。可见常温下保存离体肝脏是可能的。 | 裘华德 陈义发 Gruenert A Mueler I Schuh S | 1996 | 中华外科杂志1996，34，9： | 6 |
| 2 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 3 | Mental health in the post-COVID-19 era:challenges and the way forward显示文摘The COVID-19 pandemic has posed a serious threat to global mental health.Multiple lines of evidence suggest that there is a varying yet considerable increase in mental health issues among the general population and vulnerable groups.12 The aftermath is obscure and speculative from a social,economic,individual and public mental health perspective.Recently published studies support the existence of an emotional epidemic curve,describing a high probability of an increase in the burden of mental health issues in the post-pandemic era.34 Furthermore,previous major public health emergencies showed that more than half of the population devel-oped mental health problems and required mental health intervention.45 There is,therefore,an urgent need to reorganise existing mental health services to address the current unmet needs for mental health and to prepare for future challenges in the postpandemic era in terms of prevention and management. | Ramyadarshni Vadivel Sheikh Shoib Sarah El Halabi Samer El Hayek LamiaàEssam Drita Gashi Bytyçi Ruta Karaliuniene Andre Luiz Schuh Teixeira Sachin Nagendrappa Rodrigo Ramalho Ramdas Ransing Victor Pereira-Sanchez Chonnakarn Jatchavala Frances Nkechi Adiukwu Ganesh Kudva Kundadak | 2021 | General Psychiatry2021，34，1： | 2 |
| 4 | The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh ( Cimicifuga or Actaea racemosa )显示文摘 | Wolfgang Wuttke Hubertus Jarry Jutta Haunschild Guenter Stecher Markus Schuh Dana Seidlova-Wuttke | 2013 | Journal of Steroid Biochemistry and Molecular Biology2013，，： | 2 |
| 5 | Earth orientation parameters from VLBI determined with a Kalman filter显示文摘This paper introduces the reader to our Kalman filter developed for geodetic VLBI(very long baseline interferometry) data analysis. The focus lies on the EOP(Earth Orientation Parameter) determination based on the Continuous VLBI Campaign 2014(CONT14) data, but also earlier CONT campaigns are analyzed. For validation and comparison purposes we use EOP determined with the classical LSM(least squares method) estimated from the same VLBI data set as the Kalman solution with a daily resolution. To gain higher resolved EOP from LSM we run solutions which yield hourly estimates for polar motion and dUTl = Universal Time(UT1)-Coordinated Universal Time(UTC). As an external validation data set we use a GPS(Global Positioning System) solution providing hourly polar motion results.Further, we describe our approach for determining the noise driving the Kalman filter. It has to be chosen carefully, since it can lead to a significant degradation of the results. We illustrate this issue in context with the de-correlation of polar motion and nutation.Finally, we find that the agreement with respect to GPS can be improved by up to 50% using our filter compared to the LSM approach, reaching a similar precision than the GPS solution. Especially the power of erroneous high-frequency signals can be reduced dramatically, opening up new possibilities for highfrequency EOP studies and investigations of the models involved in VLBI data analysis.We prove that the Kalman filter is more than on par with the classical least squares method and that it is a valuable alternative, especially on the advent of the VLBI2010 Global Observing System and within the GGOS frame work. | Maria Karbon Benedikt Soja Tobias Nilsson Zhiguo Deng Robert Heinkelmann Harald Schuh | 2017 | Geodesy and Geodynamics2017，8，6： | 2 |
| 6 | A square root information filter for multi-GNSS real-time precise clock estimation显示文摘Real-time satellite orbit and clock estimations are the prerequisite for Global Navigation Satellite System(GNSS)real-time precise positioning services.To meet the high-rate update requirement of satellite clock corrections,the computational efficiency is a key factor and a challenge due to the rapid development of multi-GNSS constellations.The Square Root Information Filter(SRIF)is widely used in real-time GNSS data processing thanks to its high numerical stability and computational efficiency.In real-time clock estimation,the outlier detection and elimination are critical to guarantee the precision and stability of the product but could be time-consuming.In this study,we developed a new quality control procedure including the three standard steps:i.e.,detection,identification,and adaption,for real-time data processing of huge GNSS networks.Effort is made to improve the computational efficiency by optimizing the algorithm to provide only the essential information required in the processing,so that it can be applied in real-time and high-rate estimation of satellite clocks.The processing procedure is implemented in the PANDA(Positioning and Navigation Data Analyst)software package and evaluated in the operational generation of real-time GNSS orbit and clock products.We demonstrated that the new algorithm can efficiently eliminate outliers,and a clock precision of 0.06 ns,0.24 ns,0.06 ns,and 0.11 ns can be achieved for the GPS,GLONASS,Galileo,and BDS-2 IGSO/MEO satellites,respectively.The computation time per epoch is about 2 to 3 s depending on the number of existing outliers.Overall,the algorithm can satisfy the IGS real-time clock estimation in terms of both the computational efficiency and product quality. | Xiang Zuo Xinyuan Jiang Pan Li Jungang Wang Maorong Ge Harald Schuh | 2021 | Satellite Navigation2021，2，1： | 2 |
| 7 | Overexpression of sarcolemmal calcium pump attenuates induction of cardiac gene expression in response to ET-1 显示文摘 | Piuhola J Hammes A Schuh K | 2001 | Am J Physiol Regul Integr Comp Physiol2001，281，3： | 1 |
| 8 | Calcineurin in human heart hypertrophy 显示文摘 | RITTER O HACK S SCHUH K | 2002 | Circulation2002，105，19： | 1 |
| 9 | Lithium ion induced surface reativity change on MgO nanoparticles显示文摘 | BERGER R SCHUH J STERRER M DIWALD O KNOZINGER E | 2007 | J Catalysis2007，247，： | 1 |
| 10 | A nanoindentation study of serrated flow in bulk metallic glasses显示文摘 | Schuh C A Nieh T G | 2003 | Acta Materialia2003，，51： | 1 |
| 11 | Complexity-based mode- ling of reeonfigurable collaborations in production industry 显示文摘 | Schuh G Monostori L Csaji B C | 2008 | CIRP Annals-Manufacturing Technology2008，57，1： | 1 |
| 12 | Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary显示文摘 | Schuh R A Fiskum 3 | 2006 | Toxicol App Pharmacol2006，216，： | 1 |
| 13 | Troposphere Mapping Functions for GPS and Very Long Baseline Interferometry from European Centre for Medium-Range Weather Forecasts Operational Analysis Data 显示文摘 | Boehm J Werl B Schuh H | 2006 | Journal of Geophysical Research2006，111，： | 1 |
| 14 | Short Note:A Global Model o{ Pressure and Temperature for Geodetic Applica tions显示文摘 | B6hm J Heinkelmann R Schuh H | 2007 | Journalof Geodesy2007，81，67： | 1 |
| 15 | Calpeptin-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein(CREB)显示文摘 | Schuh RA Kristian T Fiskum G | 2005 | J Neurochem2005，92，2： | 1 |
| 16 | Characterization of the in vivo fuuction of TNF - alpha - related apoptosis - inducing ligand , TRAIL/Apo2L, using TRAIL/Apo2L gene - deficient mice显示文摘 | Sedger LM Glaccum MB Schuh JC | 2002 | Eur J Immunol2002，32，： | 1 |
| 17 | Global Mapping Function (GMF):a new empirical mapping function based on numerical weather model data显示文摘 | Boehm J Niell A Tregoning P Schuh H | 2006 | Geophysical Research Letters2006，33，73： | 1 |
| 18 | Combined Satellite Gravity Field Model GOCO01S Derived from GOCE and GRACE显示文摘 | Pail R Goiginger H Schuh W D | 2010 | Geophysical Research Letters2010，37，20： | 1 |
| 19 | Liposomal lidocaine to improve procedural success rates and reduce procedural pain among children:a randomized controlled trial显示文摘 | Taddio A Soin H K Schuh S | 2005 | CMA J2005，172，13： | 1 |
| 20 | Benchmark radar targets for the validation of computational electromagnetics programs显示文摘 | Woo A C Wang H T G Schuh M J | 1993 | IEEE Trans on Antennas Propagat1993，135，： | 1 |
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