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| 1 | Metabolomics-assisted refinement of the pathways of steroidal glycoalkaloid biosynthesis in the tomato clade显示文摘Steroidal glycoalkaloids(SGAs) are nitrogen-containing secondary metabolites of the Solanum species,which are known to have large chemical and bioactive diversity in nature.While recent effort and development on LC/MS techniques for SGA profiling have elucidated the main pathways of SGA metabolism in tomato,the problem of peak annotation still remains due to the vast diversity of chemical structure and similar on overlapping of chemical formula.Here we provide a case study of peak classification and annotation approach by integration of species and tissue specificities of SGA accumulation for provision of comprehensive pathways of SGA biosynthesis.In order to elucidate natural diversity of SGA biosynthesis,a total of 169 putative SGAs found in eight tomato accessions(Soianum lycopersicum,S.pimpinellifolium,S.cheesmaniae,S.chmielewskii,S.neorickii,S.peruvianum,S.habrochaites,S.pennellii) and four tissue types were used for correlation analysis.The results obtained in this study contribute annotation and classification of SGAs as well as detecting putative novel biosynthetic branch points.As such this represents a novel strategy for peak annotation for plant secondary metabolites. | Kevin Schwahn Leonardo Perez de Souza Alisdair R.Fernie Takayuki Tohge | 2014 | Journal of Integrative Plant Biology2014，56，9： | 6 |
| 2 | Positional cloning of the gene for X-linked retinitis pigmentosa 2显示文摘 | Schwahn U | | 0，，： | 2 |
| 3 | Decreased trabecular bone mineral densityin patients with phenylketonuria measured by peripheral quantitative computed tomography显示文摘 | Schwahn B Mokov E Scheidhauer K | 1998 | ActaPaediatr1998，87，1： | 1 |
| 4 | Diagnosis of MSUD by newborn screening allows early intervention without extraneous detoxification显示文摘 | Heldt K Schwahn B Marquardt I | | 0，，04： | 1 |
| 5 | Positional cloning of the gene for X-linked retinitis pigmentosa 2显示文摘 | SCHWAHN U LENZNER S DONG J | 1998 | Nat Genet1998，19，4： | 1 |
| 6 | lnterleukin- 1 gene polymorphism, diabetes, and periodontitis : Results from the study of health in pomerania (SHIP) 显示文摘 | Struch F Dau M Schwahn C | 2008 | J Periodontol2008，79，3： | 1 |
| 7 | The benefit of longterm growth hormone (GH) replacement therapy in hypopituitary adults with GH deficiency:results of the German KIMS database显示文摘 | Spielhagen C Schwahn C M(o)ller K | | 0，，01： | 1 |
| 8 | Novel indirubin derivatives,promising anti-tumor agents inhibiting cyclin-dependent kinases显示文摘 | Merz K H Schwahn S Hippe F et a1 | 2004 | International Journal of Clinical Pharmacology and Therapeutics2004，42，11： | 1 |
| 9 | Betaine rescue of an animal model with methylen etetrahydrofolate reduetase deficiency显示文摘 | Schwahn BC Laryea MD Chen Z | 2004 | Biochem J2004，382，3： | 1 |
| 10 | Subretinal electrical stimulation of the rabbit retina with acutely implanted electrode arrays 显示文摘 | Gekeler F Kobuch K Schwahn HN Stett A Shinoda K Zrenner E | 2004 | Graefes Arch Clin Exp Ophthalmol2004，242，7： | 1 |
| 11 | Novel indirubin derivatives, promising anti-tumor agents inhibiting cyclin dependent kinases显示文摘 | Merzk H Schwahn S Hippe F | 2004 | International Journal of Clinical Pharmacology and Therapeutics2004，4201，： | 1 |
| 12 | Positional cloning of the gene for X -linked retinitis pigmentosa 2 显示文摘 | Schwahn U Lenzner S Dong J | 1998 | Nat Genet1998，19，4： | 1 |
| 13 | Subretinal electrical stimulation of the rabbit retina with acutely implanted electrode arrays显示文摘 | Gekeler F Kobuch K Schwahn HN | 2004 | Graefe''s Arch Clin Exp Ophthalmol2004，242，7： | 1 |
| 14 | Interaction of paraffin wax gels with ethylene/vinyl acetate co-polymers显示文摘 | ASHBAUGH H S GUO X SCHWAHN D | 2005 | Energy & Fuels2005，19，1： | 1 |
| 15 | Polymorphisms in the methylenetetrahydrofolate reductase gene:clinical consequences显示文摘 | Schwahn B Rozen R | 2002 | Am J Pharmacogenomics2002，1，3： | 1 |
| 16 | Gender differences in the relationship between periodontal disease,tooth loss,and atherosclerosis显示文摘 | Desvarieux M Schwahn C Volzke H | 2004 | Stroke2004，35，19： | 1 |
| 17 | Signs of temporomandibu- lar disorders in tinnitus patients and in a population-based group of volunteers : results of the study of health in pomera- nia显示文摘 | Bernhardt O Gesch D Schwahn C | 2004 | Oral Rehabil2004，31，4： | 1 |
| 18 | A new ultrasonic device in maintenance therapy: perception of pain and clinical efficacy 显示文摘 | Kocher T Fanghane| J Schwahn C | 2005 | J Clin Periodontol2005，32，4： | 1 |
| 19 | Mutations in the X-linked RP2 gene cause intracellular misrouting and loss of the protein显示文摘 | Schwahn U Paland N Techritz S Lenzner S Berger W | | 0，，： | 1 |
| 20 | The benefit of long-term growth hormone(GH)replacement therapy in hypopituitary adults with GH deficiency:results of the German KIMS database显示文摘 | Hristin Spielhagen Christian Schwahn Kristin M¨oller | 2011 | Growth Hormone&IGF Research2011，21，： | 1 |
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