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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Superoxide dismutase-rich bacteria: Paradoxical increase in oxidant toxicity显示文摘 | Scot M D Meshnick S R Eaton J W | 1987 | Biol Chem1987，262，： | 1 |
| 3 | Stress-strain behavior of concrete confined by overlapping hoops at low and high strain rates 显示文摘 | SCOT'F B D PARK R PRISETLEY M J N | 1982 | ACI Journal1982，79，2： | 1 |
| 4 | Microbiologically influenced corrosion of alloy 904L显示文摘 | Scot P J B Davies M | 1989 | Materials Perforrnance1989，28，5： | 1 |
| 5 | High titer ethanol production from simultaneous enzymatic saccharification and fermentation of aspen at high solids:A comparison between SPORL and dilute acid pretreatments显示文摘 | Zhu J Y Gleisner R Scot C T | | 0，，： | 1 |
| 6 | Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis显示文摘 | SCOT R K LEONARD S J | 2006 | Journal Nutrition2006，136，： | 1 |
| 7 | Polyspermy barriers in plants : from preven-ting to promoting fertilization显示文摘 | SPIELMAN M SCOT R J | 2008 | Sexual Plant Reproductian2008，21，： | 1 |
| 8 | Speckle reduction anisotrop ic diffusion显示文摘 | Yu Y J Scot T A | 2002 | IEEE trans on image processing2002，11，11： | 1 |
| 9 | Functional electrotherapy:stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients显示文摘 | Liberson WT Holmquest H J Scot D | 1961 | Arch Phys Med Rehabil1961，42，2： | 1 |
| 10 | Field N~O, CO2 and CH4 fluxes in relation to tillage, compaction and soil quality in Scotland显示文摘 | Ball B C Scot T A Parker J P | 1999 | Soil and tillage Research1999，53，1： | 1 |
| 11 | Oral leucine administration stimulates protein synthesis in rat skeletal muscle 显示文摘 | STEPHEN J C SCOT R K | 2005 | Journal of Nutrition2005，135，： | 1 |
| 12 | Functional electrotherapy: stimulation of the perineal nerve synchronized with the swing phase of gait of hemiplegic patients 显示文摘 | LIBERSON W T HOLMQUEST H J SCOT D | 1961 | Arch Phys Med Rehabil1961，42，： | 1 |
| 13 | Role stress and career satisfaction among registered nurses by work shift paterns显示文摘 | Hoffman A J Scot L D | 2003 | Nurs Adm2003，33，6： | 1 |
| 14 | Functional electrotherapy:stimulation of the peroneal nerve synchronized with the swing phase of the gait of hemiplegic patients显示文摘 | Liberson W T Holmquest H J Scot D | | 0，，： | 1 |
| 15 | Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight 显示文摘 | MURPHY M M SCOT]' J M ARIJA V | 2004 | Clin Chem2004，50，8： | 1 |
| 16 | Inositol (1,4,5) P3 and cardiacdys function显示文摘 | Elizabeth A Scot J Ofer B | 1998 | Cardiovasc Res1998，40，： | 1 |
| 17 | Managing Multiple Engineering Projects in a Manufacturing Support Environment 显示文摘 | Scot E Fricke Aaron J Shenhar | 2000 | IEEE Transactions on Engineering Management2000，47，2： | 1 |
| 18 | Biodiesel from algae:chal enges and prospects显示文摘 | Scot S A Davey M P Dennis J S | | 0，，： | 1 |
| 19 | Feline viruses: Serum-neutralization test for feline panleukopenia 显示文摘 | Csiza C K Gillesple J H Scot F W | 1970 | Cornell Vet1970，60，2： | 1 |
| 20 | Feline viruses: Serum-neutralization test for feline panleukopenia显示文摘 | Scot F W Csiza C K Gillesple J H | 1970 | Cornell Vet1970，60，2： | 1 |
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