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| 1 | Towards 10 Gb/s orthogonal frequency division multiplexing-based visible light communication using a GaN violet micro-LED显示文摘Visible light communication(VLC)is a promising solution to the increasing demands for wireless connectivity.Gallium nitride micro-sized light emitting diodes(micro-LEDs)are strong candidates for VLC due to their high bandwidths.Segmented violet micro-LEDs are reported in this work with electrical-to-optical bandwidths up to 655 MHz.An orthogonal frequency division multiplexing-based VLC system with adaptive bit and energy loading is demonstrated,and a data transmission rate of 11.95 Gb/s is achieved with a violet micro-LED,when the nonlinear distortion of the micro-LED is the dominant noise source of the VLC system.A record 7.91 Gb/s data transmission rate is reported below the forward error correction threshold using a single pixel of the segmented array when all the noise sources of the VLC system are present. | MOHAMED SUFYAN ISLIM RICARDO X.FERREIRA XIANGYU HE ENYUAN XIE STEFAN VIDEV SHAUN VIOLA SCOTT WATSON NIKOLAOS BAMIEDAKIS RICHARD V.PENTY IAN H.WHITE ANTHONY E.KELLY ERDAN GU HARALD HAAS MARTIN D.DAWSON | 2017 | Photonics Research2017，5，2： | 23 |
| 2 | Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans显示文摘 | Sarah E. Medland Dale R. Nyholt Jodie N. Painter Brian P. McEvoy Allan F. McRae Gu Zhu Scott D. Gordon Manuel A.R. Ferreira Margaret J. Wright Anjali K. Henders Megan J. Campbell David L. Duffy Narelle K. Hansell Stuart Macgregor Wendy S. Slutske Andrew C | 2009 | The American Journal of Human Genetics2009，，5： | 1 |
| 3 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 4 | Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non–small cell lung cancer: Results of CALGB Protocol 39803显示文摘 | Michael T. Jaklitsch Lin Gu Todd Demmy David H. Harpole Thomas A. D’Amico Robert J. McKenna Mark J. Krasna Leslie J. Kohman Scott J. Swanson Malcolm M. DeCamp Xiaofei Wang Susan Barry David J. Sugarbaker | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，1： | 1 |
| 5 | Express primer tool for high throughput gene cloning and expression 显示文摘 | YOONJ R LAIBLE P D GU M SCOTT H N COLLART F R | 2002 | Biotechniques2002，33，： | 1 |
| 6 | Immunohistochemical evalution of bcl-2 protein expression in gastric adenocarcinomas显示文摘 | Lauwers GY Scott GU Karpeh MS | 1995 | Cancer1995，75，： | 1 |
| 7 | Bin-carver: automat- ic recovery of binary executable fries 显示文摘 | Scott Hand Zlaiqiang Lin Guofei Gu etc | 2012 | Digital Investiga- tion2012，9，： | 1 |
| 8 | Different responses of two Mosla species to potassium limitation in relation to acid rain deposition显示文摘The increasingly serious problem of acid rain is leading to increased potassium(K) loss from soils,and in our field investigation,we found that even congenerically relative Mosla species show different tolerance to K-deficiency.A hydroponic study was conducted on the growth of two Mosla species and their morphological,physiological and stoichiometric traits in response to limited(0.35 mmol K/L),normal(3.25 mmol K/L) and excessive(6.50 mmol K/L) K concentrations.Mosla hangchowensis is an endangered plant,whereas Mosla dianthera a widespread weed.In the case of M.hangchowensis,in comparison with normal K concentration,K-limitation induced a significant reduction in net photosynthetic rate(Pn),soluble protein content,and superoxide dismutase(SOD) activity,but an increase in malondialdehyde(MDA) concentration.However,leaf mass ratio(LMR) and root mass ratio(RMR) were changed little by K-limitation.In contrast,for M.dianthera,K-limitation had little effect on Pn,soluble protein content,SOD activity,and MDA concentration,but increased LMR and RMR.Critical values of N(nitrogen):K and K:P(phosphorus) ratios in the shoots indicated that limitation in acquiring K occurred under K-limited conditions for M.hangchowensis but not for M.dianthera.We found that low K content in natural habitats was a restrictive factor in the growth and distribution of M.hangchowensis,and soil K-deficiency caused by acid rain worsened the situation of M.hang-chowensis,while M.dianthera could well acclimate to the increasing K-deficiency.We suggest that controlling the acid rain and applying K fertilizers may be an effective way to rescue the endangered M.hangchowensis. | Meng WANG Bao-jing GU Ying GE Zhen LIU De-an JIANG Scott X. CHANG Jie CHANG | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，8： | 0 |
| 9 | 评估帕博利珠单抗在中国晚期黑色素瘤患者中的应用:基于KEYNOTE-151研究的3年随访数据显示文摘中国肢端和黏膜黑色素瘤的发病率较高,但治疗选择有限,晚期黑色素瘤患者的生存率普遍较低。对Ib期KEYNOTE-151研究的初步分析显示,帕博利珠单抗在作为二线药物治疗中国晚期黑色素瘤患者中,表现出了良好的耐受性和优异的临床抗肿瘤活性。本研究分析了3年随访的研究数据,纳入一线治疗后进展的不可切除的III/IV期中国黑色素瘤患者,给予帕博利珠单抗2 mg/kg治疗,每3周1次,最长使用35剂。主要终点为安全性和客观缓解率(objective response rate,ORR);次要终点包括疗效维持时间(duration of response,DOR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。根据RECIST v1.1标准,采用独立中心盲法评估患者疗效。此外,根据黑色素瘤亚型,以及BRAF突变状态和PD-L1表达状态(仅肢端黑色素瘤)进行亚组分析。本研究共纳入103例患者,中位随访时间[从首次用药到数据截止时间(2020年7月13日)]为44.6个月[四分位距(interquartile range,IQR):39.1–46.2]。85.4%的患者发生了任一级别的治疗相关不良事件(treatment-related adverse events,TRAEs),12.6%的患者发生了3/4级的TRAEs,无5级TRAE发生。3例患者因TRAEs(免疫相关肝炎、肺炎和关节炎)停药。免疫相关AEs和输液反应发生比例为34.0%(3/4级,2.9%)。ORR为17.6%(95%CI:10.8–26.4;1例完全缓解/17例部分缓解),中位DOR为13.8个月(范围:2.7–37.4+)。中位PFS为2.8个月(95%CI:2.7–3.5),36个月的PFS率为5.0%。中位OS为13.2个月(95%CI:10.4–16.5),36个月的OS率为22.3%。肢端黑色素瘤中位OS为14.8个月,非肢端皮肤黑色素瘤为13.5个月,黏膜黑色素瘤为7.4个月。在肢端黑色素瘤亚组中,程序性死亡配体-1(programmed death ligand-1,PD-L1)阳性的中位OS为22.8个月,PD-L1阴性的中位OS为8.4个月,BRAF野生型的中位OS为18.5个月,BRAF突变型的中位OS为5.8个月。综上,本研究对3年随访数据分析结果表明,帕博利珠单抗作为二线治疗在中国晚期黑色素瘤患者中的安全性可控,且达到了具有临床意义的抗肿瘤活性,使部分患者获得持久缓解。亚组分析表明PD-L1阳性和BRAF野生型的肢端黑色素瘤患者从该治疗中获益较大,但由于亚组样本量较小,该研究结论仍需进一步验证。 | Lu Si Xiaoshi Zhang Yongqian Shu Hongming Pan Di Wu Jiwei Liu Lili Mao Xuan Wang Xizhi Wen Yanhong Gu Lingjun Zhu Shijie Lan Xin Cai Scott J.Diede Haiyan Dai Cuizhen Niu Jianfeng Li Jun Guo 李雯钰(翻译校对) 斯璐(点评) | 2023 | 癌症2023，42，8： | 0 |
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