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| 1 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 2 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 4 | Ankle Fractures in the Elderly: What You Get Depends on Where You Live and Who You See显示文摘 | Kenneth J Koval Jon Lurie Weiping Zhou Michael B Sparks Robert V Cantu Scott M Sporer James Weinstein | 2005 | Journal of Orthopaedic Trauma2005，，9： | 2 |
| 5 | Effect of amphetamine precursors and by products on soil enzymes of two urban soils显示文摘 | Scott T L Janusz A Perkins M V | 2003 | Bull Environ Contam Toxical2003，70，： | 1 |
| 6 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 7 | Low temperature mechanical properties of scandium-modified Al-Zn-Mg-Cu alloys显示文摘 | SENKOY O N MIRACLE D B MILMAN Y V SCOTT J M LOTSKO D V SIRKO A I | 2002 | Materials Science Forum2002，，： | 1 |
| 8 | The Elliptic Curve Digital Signarure Algorithm (ECDSA)显示文摘 | DON J ALFRED M SCOTT V | 2004 | Lecture Notes in Computer Science2004，3269，： | 1 |
| 9 | Chemical Oxygen Demand Analysis of Waste Water Using Trivalent Mangunese Oxidant with Chloride Removal by Sodium Bismuthate Pretreatment显示文摘 | DONALD G M SCOTT V B WAYNE T B | 2001 | Water Environment Research2001，73，1： | 1 |
| 10 | Improvements in quadriceps sensori- motor function and disability of patients with knee osteoarthritis following a clinically practicable exercise regime显示文摘 | HURLEY M V SCOTT D L | 1998 | BrJRheuma- to11998，37，11： | 1 |
| 11 | E- valuation of selective defunctioning stoma after low anterior resec- tion for rectal cancer显示文摘 | Lefebure B Tuech J Bridoux V Costaglioli B Scotte M | 2008 | Int J Colorectal Dis2008，23，3： | 1 |
| 12 | Use of complementary and alternative medicine in cancer patients:a European survey显示文摘 | Molassiotis A Fernadez-Ortega P Pud D Ozden G Scott JA Panteli V Margulies A Browall M Magri M Selvekerova S Madsen E Milovics L Bruyns I Gudmundsdottir G Hummerston S Ahmad AM Platin N Keamey N Patiraki E | | 0，，04： | 1 |
| 13 | Burden of valvular heart diseases: a population-based study 显示文摘 | Nkomo V T Gardin J M Skelton T N Gottdiener J S Scott C G Enriquez-Sarano M | 2006 | Lancet2006，368，： | 1 |
| 14 | In planta regulation of extension of an endophytic fungus and maintenance of high metabolic rates in its mycelium in the absence of apical extension显示文摘 | Tan Y Y Spiering M J Scott V Lane G A Christensen M J Schmid J | 2001 | Applied and Envi- ronmental Microbiology2001，67，： | 1 |
| 15 | Compaction of amorphous aluminum alloy powder by direct extrusion and equal channel angular extrusion显示文摘 | SENKOV O N SENKOVA S V SCOTT J M MIRACLE D B | 2005 | Materials Science and Engineering2005，393，： | 1 |
| 16 | Electron Probe Microanalysis of Nicalon Fibers 显示文摘 | Bleay S M Love A R Scott V D | 1992 | Journal of Material Science1992，27，： | 1 |
| 17 | Compaction of amorphous aluminum alloy powder by direct extrusion and equal channel angular extrusion显示文摘 | SENKOV O N SENKOVA S V SCOTT J M MIRACLE D B | 2005 | Materials Science and Engineering A2005，393，： | 1 |
| 18 | A Unified Nomenclature for Yeast Autophagy-Related Genes显示文摘 | Daniel J Klionsky James M Cregg William A Dunn Scott D Emr Yasuyoshi Sakai Ignacio V Sandoval Andrei Sibirny Suresh Subramani Michael Thumm Marten Veenhuis Yoshinori Ohsumi | 2003 | Developmental Cell2003，，4： | 1 |
| 19 | Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad 2 显示文摘 | Dobles M Liberal V Scott ML | 2000 | Cell2000，101，6： | 1 |
| 20 | The Elliptic Curve Digital Signature Algorithm显示文摘 | DON J ALFRED M SCOTT V | 2007 | International Journal of Information Security2007，1，01： | 1 |
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