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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | Catatonia:Our current understanding of its diagnosis, treatment and pathophysiology显示文摘Catatonia is a psychomotor syndrome that has been reported to occur in more than 10% of patients with acute psychiatric illnesses. Two subtypes of the syndrome have been identified. Catatonia of the retarded type is characterized by immobility, mutism, staring, rigidity, and a host of other clinical signs. Excited catatonia is a less common presentation in which patients develop prolonged periods of psychomotor agitation. Once thought to be a subtype of schizophrenia, catatonia is now recognized to occur with a broad spectrum of medical and psychiatric illnesses, particularly affective disorders. In many cases, the catatonia must be treated before any underlying conditions can be accurately diagnosed. Most patients with the syndrome respond rapidly to low-dose benzodiazepines, but electroconvulsive therapy is occasionally required. Patients with longstanding catatonia or a diagnosis of schizophrenia may be less likely to respond. The pathobiology of catatonia is poorly understood, although abnormalities in gamma-aminobutyric acid and glutamate signaling have been suggested as causative factors. Because catatonia is common, highly treatable, and associated with significant morbidity and mortality if left untreated, physicians should maintain a high level of suspicion for this complex clinical syndrome. Since 1989, we have systematically assessed patients presenting to our psychiatry service with signs of retarded catatonia. In this paper, we present a review of the current literature on catatonia along with findings from the 220 cases we have assessed and treated. | Sean A Rasmussen Michael F Mazurek Patricia I Rosebush | 2016 | World Journal of Psychiatry2016，6，4： | 7 |
| 3 | The spectrum of neuromyelitis optica显示文摘 | Dean M Wingerchuk Vanda A Lennon Claudia F Lucchinetti Sean J Pittock Brian G Weinshenker | 2007 | Lancet Neurology2007，，9： | 3 |
| 4 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | 2004 (9451)2004，，9451： | 1 |
| 5 | Polymeric Microelectromechanical Systems显示文摘 | Steven A S Sean M F Shize Q | 2000 | Analytical Chemistry2000，72，： | 1 |
| 6 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | The Lancet2004，，9451： | 1 |
| 7 | STATS regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression显示文摘 | Scheeren F A Marianne N Sean D | 2005 | Nat Immunol2005，6，： | 1 |
| 8 | Hep- atocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005 显示文摘 | Sean F Ahekruse Katherine A McGlynn Marsha E Reichman | 1975 | J Clin Oncol1975，27，： | 1 |
| 9 | The expression of bone matrix proteins induced by different bioimplants in a rabbit sinus lift model显示文摘 | Hu Z M Sean A F Stephen K C | 2010 | Journal of Biomedical Materials Research Part A2010，95，2： | 1 |
| 10 | Comparison of platelet-rich plasma,bovine BMP and rhBMP-4 on bone matrix protein expression in vitro显示文摘 | Hu Z M Sean A F Stephen K C | 2009 | Growth Factor2009，27，5： | 1 |
| 11 | Comparison of human papillomavirus genotypes, sexual, and reproductive risk factors of cervical ad and squamous cell carcinoma: Northeastern United States 显示文摘 | Sean F Ahekruse James V Lacey Jr Louise A Brin - ton | 2008 | Am J Obstet Gyne-eol2008，188，3： | 1 |
| 12 | Kiwifruit L-galactose dehydrogenase:molecular,biochemical and physiological aspects of the enzyme显示文摘 | William A L Nicky F Sean B | 2004 | Functional Plant Biology2004，31，10： | 1 |
| 13 | Emulsification and microencapsulation properties of sodium caseinate/carbohydrate blends显示文摘 | Sean A Hogan Brian F McNamee E Dolores O' Riordan | 2001 | International Dairy Journal2001，11，： | 1 |
| 14 | Microencapsulating properties of sodium caseinate 显示文摘 | Sean A Hogan Brain F McNamee E Dolores O'Riordan | 2001 | JAgfic Food Chem2001，49，： | 1 |
| 15 | The spectrum of neuromyelitis optica显示文摘 | Dean M Wingerchuk Vanda A Lennon Claudia F Lucchinetti Sean J Pittock Brian G Weinshenker | 2007 | Lancet Neurology2007，，9： | 1 |
| 16 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | The Lancet2004，，9451： | 1 |
| 17 | Comparison dfhuman papillomavirus genotypes, sexual, and reproductive risk factorsof cervical adenocarcinoma and squamous cell carcinoma: NortheasternUnited States 显示文摘 | Sean F Altekruse James V Lacey Jr Louise A Brinton | 2003 | AMJ ObstetGynecol2003，188，3： | 1 |
| 18 | Comparison of human papillomavirus genotypes, sexual, and reproductive risk factors of cervical adenocarcinoma and squamous cell carcinoma:Northeastern United States显示文摘 | Sean F Altekruse James V Lacey Jr Louise A Brinton | 2008 | Am J Obstet Gynecol2008，188，3： | 1 |
| 19 | First GOCE gravity field models derived by three different approaches显示文摘 | Roland P Sean B Federica M Christoph F Helmut G Wolf D S Eduand H Mirko R Jan M B Oleg A Mantin V Thomas F Reinhard M Ina K Fernando S and Carl C T | | 0，，11： | 1 |
| 20 | Major injury leads to predominance of the T Helper-2 lymphocyte phenotype and diminished IL-12 production associated with decreased resistance to infection显示文摘 | James A Lederer Alan F Horgan | 1995 | Ann Surg1995，222，4： | 1 |
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