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| 1 | 加兰他敏治疗轻至中度阿尔茨海默病人的有效性及安全性:多中心随机对照试验显示文摘 | Gordon K Wilcock Sean Lilienfeld Els Gaens 殷剑 | 2001 | 英国医学杂志中文版2001，4，4： | 5 |
| 2 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 3 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | Plant recruitment and survival as indicators of ecological restoration success in abandoned pasture land in Nurcoung,Victoria,Australia显示文摘Introduction:One of the major impediments to developing better restoration strategies is the inadequate documentation of past restoration efforts.In 2008,Greening Australia commenced ecological restoration on the Nurcoung property in Victoria to enhance local biodiversity,and in this paper we report on the habitat restoration outcomes in the three Ecological Vegetation Classes(EVC)found on this property.Methods:Permanent sample plots(12×20 m)were randomly established in July 2010 in each of the restoration areas,with 9,10,and 24 plots demarcated in Shallow Sands Woodland(SSW),Heathy Woodland(HW),and Sandstone Ridge Woodlands(SRW),respectively.Individual plots were prepared to include three seeded rows.Plots were assessed for seedling recruitment and survival in May 2010,April 2011,and May 2012.Records of individual seedling development included their height and cover,and their location within the plot.Results:Our study shows that interaction between the age of the planted and direct-seeded vegetation and the nature of the EVC significantly affects the composition of plants and the soil surface in that species and,further,that soil cover parameters develop in different ways in the different experimental plots.A SIMPER analysis of soil cover parameters shows that most of the variation over the years of restoration is attributable to differences in the amount of bare soil recorded,rather than the amount of leaf-litter cover,and that these changes in soil cover parameters differ between EVCs over the sampling periods.The direct-seeding study shows that whilst most of the broadcast species were recruited,some species used in the Shallow Sands Woodland,the Heathy Woodland,and the Sandstone Ridge Shrubland did not show evidence of recruitment during the three sampling periods.Although the density of most seedlings increased in subsequent sampling years,the planted species Callitris gracilis,Callitris rhomboidea,Hakea muelleriana,and Melaleuca lanceolata did not survive.Conclusions:As a result of the land use change,new assemblages of abiotic and biotic system components appear to lead to the development of stable alternative ecological states.These‘novel’ecosystems now play an important part of the natural resource base,requiring careful characterization to better understand current development trajectories and future states,and to inform management strategies to meet desired restoration outcomes.Although the study sites have been abandoned for a long time,broadcast seeds and plant seedlings show they can overcome internal resilience. | Singarayer K Florentine Jessica Gardner Friedrich P Graz Sean Moloney | 2013 | Ecological Processes2013，2，1： | 2 |
| 5 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 6 | The major ion composition of Silurian seawater显示文摘 | Sean T Brennan Tim K Lowenstein | 2002 | Geochimica et Cosmochimica Acta2002，66，15： | 1 |
| 7 | Stem cells,cancer and cancer stem cells显示文摘 | Tannistha K Sean J Molberg K | 2001 | Nature2001，414，3： | 1 |
| 8 | Raman spectroscopy as a morphological probe for TiO2 aerogels 显示文摘 | Sean K Fred H P Micha T | 1997 | J Phys Chem B1997，101，14： | 1 |
| 9 | Cloud computing security 显示文摘 | SEAN C CURRAN K | 2011 | International Journal of Ambient Computing and Intelligence2011，3，1： | 1 |
| 10 | Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease:multicentre randomised controlled trail显示文摘 | GORDON K W SEAN L ELS G | 2000 | BMJ2000，321，： | 1 |
| 11 | Modeling visual attention via selective tuning 显示文摘 | TSOTSOS J K SEAN M C | 1995 | Artificial Intelligence1995，78，12： | 1 |
| 12 | Raman spectroscopy as a morphological probe for TiO2 aerogels显示文摘 | SEAN K FRED H P MICHA T | 1997 | J Phys Chem B1997，101，： | 1 |
| 13 | Modeling visual attention via selective tuning显示文摘 | Tsotsos John K Culhance Sean M Wai Winky Yan Kei | 1995 | Artificial Intelligence1995，78，1： | 1 |
| 14 | Macrophages and Progressive tubulointerstitial disease 显示文摘 | Sean Eardley K Cockwell P | 2005 | Kidney Int2005，68，2： | 1 |
| 15 | Appropiate measures and consistent standard for high energy laser beam quality显示文摘 | SEAN K T LATHAM W P | 2006 | Journal of Directed Energy2006，2，： | 1 |
| 16 | Intramedullary nailing of metaphyseal distal tibial fractures 显示文摘 | Sean E Alexandra K Schwartz | 2005 | J Bone Joint Surg2005，87，： | 1 |
| 17 | Intram edallary nailing of metaphyseal distal tib ial fractures显示文摘 | Sean E Alexandra K Scbwart Z | 2005 | J Bone Joint Surg2005，87，51： | 1 |
| 18 | Towards an Energy based Runoff Generation Theory for Tundra Landscapes显示文摘 | William L Quinton Sean K Carey | 2008 | Hydrological Processes2008，22，23： | 1 |
| 19 | Macrophages and progressive tubulointerstitial disease显示文摘 | Sean Eardley K Cockwell P | 2005 | Kidney Int2005，68，2： | 1 |
| 20 | Hydrodynamic simulation of horizontal slurry pipeline flow using ANSYS-CFX显示文摘 | Ekambara K Sean Sanders R Nandakumar K | 2009 | Industrial&Engineering Chemistry Research2009，48，17： | 1 |
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