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| 1 | 成都市大学生男男性行为人群艾滋病性病高危行为现状调查显示文摘[目的]了解成都市大学生男男性行为(MSM)人群性行为现状,为制定高危人群防治策略提供依据。[方法]采取'网络调查'和传统'滚雪球'调查相结合的方法对成都市大学生MSM人群性行为进行调查,所有数据使用SPSS13.0进行分析。[结果]回收有效问卷共617份。调查对象平均年龄(21.51±2.27)岁。62.4%的受访者自我认同为同性恋,28.8%的受访者自我认同为双性恋。89.5%的受访者认为同性恋是正常性行为,21.5%的受访者认为自己以后不会与异性结婚,有21.4%的受访者已经与异性发生过性行为。41.8%的受访者近1个月与固定性伴每次肛交都使用安全套,62.9%的受访者与固定性伴最近1次肛交时使用了安全套;56.7%的受访者近1个月与非固定性伴每次肛交都使用安全套,25.1%受访者与非固定性伴最近1次肛交时未使用安全套。艾滋病性病知识来源于综合网站和同志网站分别是59.8%和42.5%,来源于朋友和同志工作组分别为24.5%和15.4%。[结论]高危行为在大学生MSM群体中存在,该群体大多数同志并未意识到所面临的HIV及性病威胁。未来的干预应重点增加对大学生男同性恋群体自我认同及心理支持的关注,有针对性的开发安全套推广策略以及创新性的动员大学生同志开展与其环境和群体文化相适应的干预活动形式。 | 邓斌 江华 王文渊 Charles Damien Lu Sean Robert Dickson 赖文红 杨浩 刘毅 | 2010 | 现代预防医学2010，37，8： | 29 |
| 2 | 中国男男性行为群体HIV干预面临的挑战:基于社区和已发表证据的循证评价显示文摘目的对中国男男性行为人群中艾滋病干预面临的挑战进行初步循证评价。方法社区证据来源于对相关工作者、专家的访谈以及近5年对国内同志艾滋病防治活动的参与经验。已发表文献的证据,通过确定检索策略、入选标准和特定关键词,采用系统化的文献检索,收集与研究目的有关的文献,检索数据库包括中国生物医学文献数据库(1996-2007)、MEDLINE(1996-2007)及相关网页。结果以社区组织为基础和以'扩散理论'为指导的干预模式在知识传播、行为改变方面面临巨大挑战。表现为传递的教育信息质量低、教育娱乐化、安全套可及性不足,心理社会支持重视不够等问题。此外,普遍存在的滥用公共卫生术语'MSM'的现象。缺乏对MSM群体的社会及文化特征的研究。结论中国MSM群体中的艾滋病防治策略需要做大的调整和改进。需要建立高效的媒体反应机制以消除错误信息,应在政策上纳入反对性倾向歧视,大力倡导感染者参与,鼓励对MSM中不同群体的社会、心理需求进行更多研究,民间组织在促进男同性性行为者的自我认同、心理支持方面进行更多工作。应将循证项目评估原理和方法整合成项目评估体系。 | 江华 Charles Damien Lu 魏伟 张建新 顾仪 Sean Robert Dickson 江晖 | 2009 | 预防医学情报杂志2009，25，7： | 4 |
| 3 | Growing Operational Use of FY-3 Data in the ECMWF System显示文摘This paper reviews the data quality and impact of observations from the FY-3 satellite series used operationally in the ECMWF system. This includes data from the passive microwave radiometers MWHS-1, MWHS-2 and MWRI, as well as observations from the radio occultation receiver GNOS. Evaluations against background equivalents show that the quality of the observations is broadly comparable to that of similar instruments on other polar-orbiting satellites, even though biases for the passive microwave observations can be somewhat larger and more complex for some channels. An observing system experiment shows that the FY-3 instruments jointly contribute significantly to the forecast skill in the ECMWF system. Positive impact of up to 2% is seen for most variables out to the day-2 forecasts over hemispheric scales, with significant benefits for total column water vapor or for temperature and wind in the stratosphere out to day 4. | Niels BORMANN David DUNCAN Stephen ENGLISH Sean HEALY Katrin LONITZ Keyi CHEN Heather LAWRENCE Qifeng LU | 2021 | Advances in Atmospheric Sciences2021，38，8： | 3 |
| 4 | Nonmetabolic functions of metabolic enzymes in cancer development显示文摘Metabolism is a fundamental biological process composed of a series of reactions catalyzed by metabolic enzymes.Emerging evidence demonstrates that the aberrant signaling in cancer cells induces nonmetabolic functions of meta-bolic enzymes in many instrumental cellular activities,which involve metabolic enzyme-mediated protein post-trans-lational modifications,such as phosphorylation,acetylation,and succinylation.In the most well-researched literatures,metabolic enzymes phosphorylate proteins rather than their metabolites as substrates.Some metabolic enzymes have altered subcellular localization,which allows their metabolic products to directly participate in nonmetabolic activities.This review discusses how these findings have deepened our understanding on enzymes originally classi-fied as metabolic enzymes,by highlighting the nonmetabolic functions of several metabolic enzymes responsible for the development of cancer,and evaluates the potential for targeting these functions in cancer treatment. | Sean Lu Yugang Wang | 2018 | Cancer Communications2018，38，1： | 2 |
| 5 | Optimization of compression formulation and load of food-grade tracers for grain traceability using central composite design显示文摘Food-grade tracers have been developed as an identification technology for grain traceability from original harvest to final destination for transportation.The characteristics of food-grade tracers must be able to satisfy the environmental demands for grain traceability.To optimize the food-grade tracer production process,the effects of direct compression formulation and load on the mechanical characteristics were studied using response surface methodology(RSM)with central composite design(CCD).Among the four tested formulations,Formulations#2(consisting of 35.00%lactose 100 mesh,64.50%microcrystalline cellulose 102 and 0.50%magnesium stearate)and#4(consisting of 38.00%lactose 100 mesh,50.00%microcrystalline cellulose 102,11.00%pregelatinized starch and 1.00%magnesium stearate)were selected for tracer production based on their physical properties as powders.The value of Carr’s flowability index was 68 for both Formulations#2 and#4,which was the highest among all the formulations.Therefore,Formulations#2 and#4 also had the best powder flowability.The magnesium stearate ratio(1.00%-3.00%)and pressure(6.00-16.00 kgf)were used as independent variables to detect changes in the breaking rate,peak shear force and friction coefficient of tracers compressed by the selected formulations.The optimal production parameters could be achieved at a magnesium stearate ratio of 2.25%and pressure of 16.00 kgf for Formulation#2 and at a magnesium stearate ratio of 1.02%and pressure of 16.00 kgf for Formulation#4.Under these optimal conditions,the tracers had good impact characteristics(breaking rate),compression characteristics(peak shear force)and frictional characteristics(friction coefficient).Moreover,Formulation#2 was more suitable for production because compared to Formulation#4,its breaking rate and friction coefficient values were lower,and its peak shear force value was higher. | Liang Kun Zhang Lingling Lu Wei Cedric Sean Okinda Shen Mingxia | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 2 |
| 6 | Effect of H2 on the etch profile of InP/InGaAsP alloys in Cl2/Ar/H2 inductively coupled plasma reactive ion etching chemistries for photonic device fabrication 显示文摘 | Sean L Rommel Jae- Hyung Jang Wu Lu | 2002 | J Vac Sci Technol2002，20，4： | 1 |
| 7 | Fragile watermarking for authenticating 3-D polygonal meshes 显示文摘 | Lin Hsueh-yi Sean Liao Hong-yuan Mark Lu Chun-Shien | 2005 | IEEE Transactions on Multimedia2005，7，6： | 1 |
| 8 | 代谢酶在癌症发展中的非代谢功能显示文摘代谢是一种基本的生物学过程,由代谢酶催化的一系列反应组成。最新研究发现,在许多重要的细胞活动中,癌细胞的异常信号可以诱导代谢酶的非代谢功能,包括代谢酶介导的蛋白质翻译后修饰,例如磷酸化、乙酰化和琥珀酰化。目前研究最多的是代谢酶使蛋白质磷酸化,而不是将其作为代谢底物。一些代谢酶改变了亚细胞定位,使其代谢产物直接参与非代谢活动。本综述着重介绍了几种引起癌症发展的代谢酶的非代谢功能,加深了我们对这些代谢酶的理解,并评估了靶向这些酶的非代谢功能的治疗方法在癌症治疗中的潜在价值。 | Sean Lu Yugang Wang | 2019 | 癌症2019，38，5： | 0 |
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