|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Macrophage inhibitory cytokine-1/growth differentiation factor-15 in premalignant and neoplastic tumours in a high-risk pancreatic cancer cohort显示文摘BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late diagnosis.Currently,biomarkers have limited use in early diagnosis of PC.Macrophage inhibitory cytokine-1 or growth differentiation factor-15(MIC-1/GDF15)has been implicated as a potential serum biomarker in PC and other malignancies.AIM To determine the role of MIC-1/GDF15 in detecting pre-malignant pancreatic lesions and neoplastic tumours in an asymptomatic high-risk cohort part of Australian Pancreatic Cancer Screening Program.METHODS A feasibility prospective single centre cohort study was performed.Participants recruited for yearly surveillance with endoscopic ultrasound(EUS)had serial fasting blood samples collected before EUS for MIC-1/GDF15,C-reactive protein and carbohydrate antigen 19-9.Patients were stratified into five groups based on EUS findings:Normal;pancreatic cysts,branch-duct intraductal papillary mucinous neoplasm;diffuse non-specific abnormalities;and neoplastic tumours.MIC-1/GDF15 serum levels were quantified using ELISA.Participants in whom EUS demonstrated abnormalities but not malignancy were closely followed up with magnetic resonance imaging(MRI)or computed tomography.RESULTS One hundred twenty participants were prospectively recruited from 2011-2018.Forty-seven participants(39.2%)had an abnormal EUS and five participants(4.2%)were diagnosed with neoplastic tumours,three by EUS(two pancreatic and one liver)and two by MRI/computed tomography(breast cancer,bladder cancer),which were performed for follow up of abnormal EUS.Baseline serum MIC-1/GDF15 was a significant predictor of neoplastic tumours on receiver operator characteristic curve analysis[area under curve(AUC)=0.814,P=0.023].Baseline serum MIC-1/GDF15 had moderate predictive capacity for branch-duct intraductal papillary mucinous neoplasm(AUC=0.644)and neoplastic tumours noted on EUS(AUC=0.793),however this was not significant(P=0.188 and 0.081 respectively).Serial serum MIC-1/GDF15 did not demonstrate a significant percentage change between a normal and abnormal EUS(P=0.213).Median baseline MIC-1/GDF15 was greater in those with neoplastic tumours(Median=1039.6,interquartile range=727.0-1977.7)compared to those diagnosed with a benign lesion(Median=570.1,interquartile range=460.7-865.2)on EUS and MRI(P=0.012).CONCLUSION In this pilot study MIC-1/GDF15 has predictive capacity for neoplastic tumours in asymptomatic individuals with a genetic predisposition for PC.Further imagining may be warranted in patients with abnormal EUS and raised serum MIC-1/GDF15.Larger multicentric prospective studies are required to further define the role of MIC-1/GDF15 as a serological biomarker in pre-malignant pancreatic lesions and neoplastic tumours. | Robert Sean O’Neill Sam Emmanuel David Williams Alina Stoita | 2020 | World Journal of Gastroenterology2020，26，14： | 8 |
| 2 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 3 | Mathematical Modeling in Social Network Analysis: Using TOPSIS to Find Node Influences in a Social Network显示文摘 | William P Fox Sean F. Everton | 2013 | Journal of Mathematics and System Science2013，3，10： | 4 |
| 4 | Complete eradication of hepatic metastasis from colorectal cancer by Yttrium-90 SIRT显示文摘Yttrium-90 (Y-90) radioembolization,also known as selective internal radiation therapy (SIRT),is a regional hepatic therapy used in the treatment of unresectable colorectal cancer (CRC) liver metastases. In SIRT,Y-90 impregnated microspheres are injected into the VASCULAR SUPPLY of hepatic tumor,leading to selective irradiation and necrosis of tumor TISSUE. While several studies demonstrate improved local control and survival with SIRT,the specific indications for this therapy have yet to be defined. Typically,SIRT is given in combination with chemotherapy as multimodal treatment for unresectable hepatic CRC. However,it HAS ALSO FOUND INCREASING USE as a salvage therapy in chemo-refractory patients. Herein,the authors describe their experience with SIRT as 'stand alone' therapy in a surgically-prohibitive,chemotherapy naive patient with hepatic CRC metastasis. The results suggest that Y-90 SIRT may have potential applications beyond its usual role as a palliative or salvage therapy for unresectable hepatic CRC. | Sean Garrean Amanda Muhs James T Bui Michael J Blend Charles Owens William S Helton Nocif J Espat | 2007 | World Journal of Gastroenterology2007，13，21： | 4 |
| 5 | Two-photon lithography for 3D magnetic nanostructure fabrication显示文摘铁磁性的材料作为在数据存储设备记录媒介许多十年被利用了。到一架二维的飞机的材料的监禁是在完成超离频的记录的一个重要瓶颈密度,和这导致了提议三维(3D ) 利用领域的跑道记忆沿着 nanowires 围繁殖。然而,复杂几何学的磁性的 nanostructures 高度容易正在质问并且不是的 3D 的制造与标准平版印刷术技术完成了。这里,我们表明一条新途径构造 3D 用二光子的平版印刷术和电气化学的免职的联合的复杂几何学的磁性的 nanostructures。磁性被发现是亲密地,与结构,和磁性的成像的 3D 几何学有关,实验提供领域墙在 3D nanostructured 连接卡住的证据。 | Gwilym Williams Matthew Hunt Benedikt Boehm Andrew May Michael Taverne Daniel Ho Sean Giblin Dan Read John Rarity Rolf Allenspach Sam Ladak | 2018 | Nano Research2018，11，2： | 3 |
| 6 | Open Reduction and Internal Fixation of High-Energy Tibial Plateau Fractures显示文摘 | William J Mills Sean E Nork | 2002 | Orthopedic Clinics of North America2002，，1： | 2 |
| 7 | A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis显示文摘 | WILLIAM A LAING SEAN B | 2004 | PNAS2004，48，16： | 1 |
| 8 | The impact of implantable cardioverter-defibrillator therapy on survival in autosomal-dominant arrhythmogenic right ventricular cardiomyopathy (ARVD5)显示文摘 | Kathy A. Hodgkinson Patrick S. Parfrey Anne S. Bassett Christine Kupprion J?rg Drenckhahn Mark W. Norman Ludwig Thierfelder Susan N. Stuckless Elizabeth L. Dicks William J. McKenna Sean P. Connors | 2005 | Journal of the American College of Cardiology2005，，3： | 1 |
| 9 | Complications Associated With Internal Fixation of High-Energy Bicondylar Tibial Plateau Fractures Utilizing a Two-Incision Technique显示文摘 | David P. Barei Sean E. Nork William J. Mills M. Bradford Henley Stephen K. Benirschke | 2004 | Journal of Orthopaedic Trauma2004，，10： | 1 |
| 10 | Transpiration of cottonwood/willow forest estimated from sap flux 显示文摘 | Sean M Schaeffer David G Williams David C Goodrich | 2000 | Agricultural and Forest Meteorology2000，105，： | 1 |
| 11 | Bile duct injuries 12 years after the introduction of laparoscopic cholecystectomy显示文摘 | William C. Chapman M.D Michael Abecassis M.D. William Jarnagin M.D. Sean Mulvihill M.D. Steven M. Strasberg M.D | 2003 | Journal of Gastrointestinal Surgery2003，，3： | 1 |
| 12 | Prospective assessment of lymphatic dissemination in endometrial cancer: A paradigm shift in surgical staging显示文摘 | Andrea Mariani Sean C. Dowdy William A. Cliby Bobbie S. Gostout Monica B. Jones Timothy O. Wilson Karl C. Podratz | 2008 | Gynecologic Oncology2008，，1： | 1 |
| 13 | Towards an Energy based Runoff Generation Theory for Tundra Landscapes显示文摘 | William L Quinton Sean K Carey | 2008 | Hydrological Processes2008，22，23： | 1 |
| 14 | Microstructure and mechanical characterization of ZrC–Mo cermets produced by hot isostatic pressing显示文摘 | Sean E. Landwehr Gregory E. Hilmas William G. Fahrenholtz Inna G. Talmy Stephen G. DiPietro | 2008 | Materials Science & Engineering A2008，，1： | 1 |
| 15 | Infants under 1 year of age have a significant risk of burn injury显示文摘 | DAI Q A NGUYEN SEAN TOBIN WILLIAM A DICKSON | 2008 | Burns2008，34，7： | 1 |
| 16 | Attachment and growth of anchorage-dependent cells on a novel, charged-surface microcarrier under serum-free conditions显示文摘 | James Varani Felicia Piel Sean Josephs Ted F. Beals William J. Hillegas | 1998 | Cytotechnology (-)1998，，1： | 1 |
| 17 | Nitrogen,Weeds and water as yield-limiting factors in conventional,low-input, and organic tomato systems显示文摘 | M Sean Clark William R Horwath Carol Shennan | 1999 | Agriculture Ecosystems and Environment1999，73，： | 1 |
| 18 | Kiwifruit L-galactose dehydrogenase:molecular,biochemical and physiological aspects of the enzyme显示文摘 | William A L Nicky F Sean B | 2004 | Functional Plant Biology2004，31，10： | 1 |
| 19 | Detection of Progressive Cardiac Dysfunction by Serial Evaluation of Circumferential Strain in Patients With Duchenne Muscular Dystrophy显示文摘 | Sean C. Hagenbuch William M. Gottliebson Janaka Wansapura Wojciech Mazur Robert Fleck D. Woodrow Benson Kan N. Hor | 2010 | The American Journal of Cardiology2010，，： | 1 |
| 20 | Liver transplantation in patients with severe portopulmonary hypertension treated with preoperative chronic intravenous epoprostenol显示文摘 | Henkie P. Tan Jay S. Markowitz Robert A. Montgomery William T. Merritt Andrew S. Klein Paul J. Thuluvath F.Fred Poordad Warren R. Maley Bradford Winters Seda B. Akinci Sean P. Gaine | 2001 | Liver Transplantation2001，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员