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| 1 | Osteoporosis and obesity: Role of Wnt pathway in human and murine models显示文摘Studies concerning the pathophysiological connection between obesity and osteoporosis are currently an intriguing area of research.Although the onset of these two diseases can occur in a different way,recent studies have shown that obesity and osteoporosis share common genetic and environmental factors.Despite being a risk factor for health,obesity has traditionally been considered positive to bone because of beneficial effect of mechanical loading,exerted by high body mass,on bone formation.However,contrasting studies have not achieved a clear consensus,suggesting instead that excessive fat mass derived from obesity condition may not protect against osteoporosis or,even worse,could be rather detrimental to bone.On the other hand,it is hitherto better established that,since adipocytes and osteoblasts are derived from a common mesenchymal stem cell precursor,molecules that lead to osteoblastogenesis inhibit adipogenesis and vice versa.Here we will discuss the role of the key molecules regulating adipocytes and osteoblasts differentiation,which are peroxisome proliferators activated receptor-γand Wnts,respectively.In particular,wewill focus on the role of both canonical and non-canonical Wnt signalling,involved in mesenchymal cell fate regulation.Moreover,at present there are no experimental data that relate any influence of the Wnt inhibitor Sclerostin to adipogenesis,although it is well known its role on bone metabolism.In addition,the most common pathological condition in which there is a simultaneous increase of adiposity and decrease of bone mass is menopause.Given that postmenopausal women have high Sclerostin level inversely associated with circulating estradiol level and since the sex hormone replacement therapy has proved to be effective in attenuating bone loss and reversing menopause-related obesity,we hypothesize that Sclerostin contribution in adipogenesis could be an active focus of research in the coming years. | Graziana Colaianni Giacomina Brunetti Maria Felicia Faienza Silvia Colucci Maria Grano | 2014 | World Journal of Orthopedics2014，5，3： | 19 |
| 2 | Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients.显示文摘A substantial proportion of patients with irritable bowel syndrome(IBS) associate their symptoms with the ingestion of specific foods. Therefore, in recent years, scientific research has increasingly focused on the role of diet in IBS and dietary management is now considered an important tool in IBS treatment. This article reviews the main dietary approaches in IBS emphasizing evidence from experimental and observational studies and summarizing the main diet and lifestyle recommendations provided by dietary guidelines and scientific literature. Despite the limited evidence for a beneficial role, general advice on healthy eating and lifestyle is recommended as the first-line approach in the dietary management of IBS. Standard recommendations include adhering to a regular meal pattern, reducing intake of insoluble fibers, alcohol, caffeine, spicy foods, and fat, as well as performing regular physical activity and ensuring a good hydration. Second-line dietary approach should be considered where IBS symptoms persist and recommendations include following a low FODMAP diet, to be delivered only by a healthcare professional with expertise in dietary management. The efficacy of this diet is supported by a growing body of evidence. In contrast, the role of lactose or gluten dietary restriction in the treatment of IBS remains subject to ongoing research with a lack of high-quality evidence. Likewise, further clinical trials are needed to conclude the efficacy of probiotics on IBS symptoms. | Anamaria Cozma-Petrut Felicia Loghin Doina Miere Dan Lucian Dumitrascu | 2017 | World Journal of Gastroenterology2017，23，21： | 16 |
| 3 | Optimization of cavitation venturi tube design for pico and nano bubbles generation显示文摘Hydrodynamic cavitaion venturi tube technique is used for pico and nano bubble generations in coal column flotation. In order to determine the optimal design of hydrodynamic cavitation venture tube for pico and nano bubble generation, a four-factor three-level Central Composite Design of Experimental was conducted for investigating four important design parameters of cavitation venturi tube governing the median size and the volume of pico and nano bubbles. The test results showed that maximum volume of pico and nano bubbles, 65–75%, and minimum mean pico and nano bubble size,150–240 nm, were achieved at the medium ratio of the diameter of outlet of the venturi-tube and diameter of throat(3–4), medium outlet angle(11–13°), high inlet angle(26–27°) and high ratio of the length of the throat and the diameter of throat(2.3–3). Study the effects of the producing pico and nano bubbles on fine coal flotation was performed in a 5 cm diameter 260 cm height flotation column. The optimal percentage of pico and nano bubbles was about 70%, which produced maximum combustible material recovery of 86% with clean coal ash content of 11.7%. | Xiong Yu Peng Felicia | 2015 | International Journal of Mining Science and Technology2015，25，4： | 14 |
| 4 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 5 | 美国选煤厂煤泥分选工艺特点显示文摘美国多数选煤厂采用重介选煤工艺(浅槽和旋流器),脱泥粒度一般为1.0~2.0mm。细粒煤的分选有三种典型流程:一段水力旋流器+螺旋分选机流程,分选下限0.147mm;两段水力旋流器+螺旋分选机流程,分选下限0.045mm;一段水力旋流器+螺旋分选机+浮选流程.分选下限为0。文章旨在介绍美国选煤厂典型煤泥分选工艺的特点。 | 李建光 夏云凯 Felicia Peng | 2006 | 选煤技术2006，34，2： | 13 |
| 6 | 海洋鱼类分割加工废弃物的综合利用显示文摘在海洋鱼类分割加工过程中会产生大量的加工废弃物,其重量可占原料鱼的20%~70%。综述了海洋鱼类分割加工所产生的鱼头、鱼骨、鱼皮、内脏等废弃物的综合利用技术研究状况,提出海洋鱼类废弃物综合利用技术应用前景。 | 黄东雨 陈海光 Felicia kow | 2009 | 广东农业科学2009，36，9： | 11 |
| 7 | 外用脂肪干细胞培养上清液对二氧化碳点阵激光焕肤术后伤口愈合的影响显示文摘目的探讨局部外用脂肪干细胞培养上清液在二氧化碳点阵激光焕肤术后伤口愈合过程中的作用。方法 9名受试者的双侧前臂内侧分别接受二氧化碳点阵激光治疗。随机选择受试者一侧前臂激光治疗处外敷脂肪干细胞培养上清液,另一侧则外敷DMEM细胞培养基。分别在上述处理后第1,4,7,14,21天检测受试部位经皮水分丢失、皮肤颜色及皮肤弹性。结果经过局部外用脂肪干细胞培养上清液一侧的红斑指数、黑色素指数和经皮水分丢失均显著低于对照侧。而皮肤弹性与对照侧差异无统计学意义。结论局部应用脂肪干细胞培养上清液是促进二氧化碳点阵激光焕肤术后伤口愈合和减少不良影响的一种有效方法。 | 周炳荣 许阳 徐妍 王影 朱丰 Felicia Permatasari 吴迪 尹志强 骆丹 | 2013 | 中国中西医结合皮肤性病学杂志2013，12，5： | 11 |
| 8 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 9 | 筛网沉降离心机在美国选煤厂粉煤脱水中的应用显示文摘介绍了美国筛网沉降离心机的构造和工作原理及在美国的应用情况,该机处理能力大、产品水分低、自动化程度高,主要应用于2.00mm以下的粉煤脱水工艺,但固体回收率低,可通过改善工艺流程或添加药剂等方式提高细粒煤泥的回收率;该机在我国应用前景广阔。 | 李建光 Felicia Peng | 2006 | 煤炭加工与综合利用2006，，6： | 7 |
| 10 | Pico–nano bubble column flotation using static mixer-venturi tube for Pittsburgh No.8 coal seam显示文摘The flotation process is a particle-hydrophobic surface-based separation technique. To improve the essential flotation steps of collision and attachment probabilities, and reduce the step of detachment probabilities between air bubbles and hydrophobic particles, a selectively designed cavitation venturi tube combined with a static mixer can be used to generate very high numbers of pico and nano bubbles in a flotation column. Fully embraced by those high numbers of tiny bubbles, hydrophobic particles readily attract the tiny bubbles to their surfaces. The results of column flotation of Pittsburgh No. 8 seam coal are obtained in a 5.08 cm ID and 162 cm height flotation column equipped with a static mixer and cavitation venturi tube, using kerosene as collector and MIBC as frother. Design of the experimental procedure is combined with a statistical two-stepwise analysis to determine the optimal operating conditions for maximum recovery at a specified grade. The effect of independent variables on the responses has been explained. Combustible material recovery of 85–90% at clean coal product of 10–11% ash is obtained from feed of 29.6% ash, with a much-reduced amount of frother and collector than that used in conventional column flotation. The column flotation process utilizing pico and nano bubbles can also be extended to the lower limit and upper limit of particle size ranges, minus 75 lm and 300–600 lm, respectively, for better recovery. | Peng Felicia F. Yu Xiong | 2015 | International Journal of Mining Science and Technology2015，25，3： | 7 |
| 11 | 海洋鱼类废弃物功能成分提取的研究显示文摘综述海洋鱼类加工废弃物中功能成分的利用价值、提取方法,以及国内外对其功能成分的利用现状,分析海洋鱼类加工废弃物综合利用中存在的问题并提出其发展趋势。 | 陈海光 黄东雨 Felicia kow | 2010 | 食品与机械2010，26，3： | 6 |
| 12 | Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk显示文摘We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regeneration after acetaminophen(APAP)hepatotoxicity.Here,we hypothesized that exogenous PA is also beneficial.To test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)posttreatment.We then collected blood and liver at 6,24,and 52 h.Post-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAC)reduced injury more than NAC alone.Interestingly,PA did not affect canonical mechanisms of APAP toxicity.Instead,transcriptomics revealed that PA activated interleukin-6(IL-6)signaling in the liver.Consistent with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphorylation increased in PA-treated mice.Furthermore,PA failed to protect against APAP in IL-6-deficient animals.Interestingly,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating IL-6.Surprisingly,however,exogenous PA did not alter regeneration,despite the importance of endogenous PA in liver repair,possibly due to its short half-life.These data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective effects of IL-6 in this model. | Melissa M.Clemens Stefanie Kennon-McGill Joel H.Vazquez Owen W.Stephens Erich A.Peterson Donald J.Johann Felicia D.Allard Eric U.Yee Sandra SMcCullough Laura P.James Brian N.Finck Mitchell R.McGill | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
| 13 | ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population显示文摘背景受体酷氨酸象kinase一样孤儿受体 2 ( ROR2 )基因最近被显示了在动物模型在腭的开发起重要作用并且居住在连接到的 chromosomal 区域非, syndromic 劈开嘴唇与或没有在学习是调查可能的协会在之间的这的 humans.The 目的劈开腭 ROR2 基因和 non-syndromic 我们测试了的这里的口头的 clefts.Methods 在在 297 non-syndromic 的 ROR2 基因的 38 合格单个核苷酸的多型性( SNP ) | Wang Hong Hetmanski, Jacqueline B. Ruczinski, Ingo Liang, Kung Yee Fallin, M. Daniele Redett, Richard J. Raymond, Gerald V. Chou, Yah-Huei Wu Chen, Philip Kuo-Ting Yeow, Vincent Chong, Samuel S. Cheah, Felicia S. H. Jabs, Ethylin Wang Scott, Alan F. Beaty, Terri H. | 2012 | Chinese Medical Journal2012，，3： | 5 |
| 14 | Doege-Potter syndrome by malignant solitary fibrous tumor of the liver: A case report and review of literature显示文摘BACKGROUND Solitary fibrous tumor of the liver (SFTL) is a rare occurrence with a low number of cases reported in literature. SFTL is usually benign but, 10%-20% cases are reported to be malignant with a tendency to metastasize. The majority of malignant SFTL cases are associated with a paraneoplastic hypoglycaemia defined as Doege-Potter syndrome. Surgery is the best therapeutic treatment, however, long- life follow-up is recommended. CASE SUMMARY A 74-year-old man, was admitted to the emergency department after a syncopal episode with detection of hypoglycaemia resistant to medical treatment. The computed tomography revealed a solid mass measuring 15 cm of the left liver. An open left hepatectomy was performed with complete resection of tumor. Histopathological analyses confirmed a malignant SFTL. CONCLUSION Large series with long-term follow-up have not been published neither have clinical trials been undertaken. Consequently, the methodical long-term followup of surgically treated SFTLs is strongly recommended. | Delvecchio Antonella Duda Loren Conticchio Maria Fiore Felicia Lafranceschina Stefano Riccelli Umberto Cristofano Antonella Pascazio Bianca Colagrande Anna Resta Leonardo Memeo Riccardo | 2019 | World Journal of Gastrointestinal Surgery2019，11，8： | 5 |
| 15 | Mechanisms of altered bone remodeling in children with type 1 diabetes显示文摘Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in life.The mechanisms underlying diabetic bone fragility are not yet completely understood.Hyperglycemia and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and microarchitecture.Several factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone turnover.Some myokines may have a key role in regulating metabolic control and improving bone mass in T1DM subjects.The aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM. | Giacomina Brunetti Gabriele D'Amato Stefania De Santis Maria Grano Maria Felicia Faienza | 2021 | World Journal of Diabetes2021，12，7： | 3 |
| 16 | Chronic hepatitis B, nonalcoholic steatohepatitis and physical fitness of military males: CHIEF study显示文摘AIM To investigate the association of chronic hepatitis B and nonalcoholic steatohepatitis with physical fitness in a Taiwan Residents military male cohort.METHODS We made a cross-sectional examination of this association using 3669 young adult military males according to cardiorespiratory fitness and hospitalization events recorded in the Taiwan Armed Forces study. Cases of chronic hepatitis B(n = 121) were defined by personal history and positive detection of hepatitis B surface antigen. Cases of nonalcoholic steatohepatitis(n = 129) were defined by alanine transaminase level > 60 U/L, liver ultrasound finding of steatosis, and absence of viral hepatitis A, B or C infection. All other study participants were defined as unaffected(n = 3419). Physical fitness was evaluated by performance in 3000-m run, 2-min sit-ups, and 2-min push-ups exercises, with all the procedures standardized by a computerized scoring system. Multiple linear regression analysis was used to determine the relationship.RESULTS Chronic hepatitis B negatively correlated with 2-min push-up numbers(β =-2.49, P = 0.019) after adjusting for age, service specialty, body mass index, systolic and diastolic blood pressures, current cigarette smoking, alcohol intake status, serum hemoglobin, and average weekly exercise times. Nonalcoholic steatohepatitis was borderline positively correlated with 3000-m running time(β = 11.96, P = 0.084) and negatively correlated with 2-min sit-up numbers(β =-1.47, P = 0.040). CONCLUSION Chronic hepatitis B viral infection and nonalcoholic steatohepatitis affects different physical performances in young adult military males, and future study should determine the underlying mechanism. | Yu-Jung Chen Kai-Wen Chen Yu-Leung Shih Fang-Ying Su Yen-Po Lin Fan-Chun Meng Felicia Lin Yun-Shun Yu Chih-Lu Han Chih-Hung Wang Jia-Wei Lin Tsai-Yuan Hsieh Yi-Hwei Li Gen-Min Lin | 2017 | World Journal of Gastroenterology2017，23，25： | 2 |
| 17 | 肺癌全基因组测序显示文摘肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为'下一代测序技术'的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免'无辜'患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。 | Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚 何建行 | 2013 | 国际病理科学与临床杂志2013，33，4： | 2 |
| 18 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 19 | FACTORS AFFECTING EARLY MORTALITY IN SPONTANEOUS RUPTURE OF HEPATOCELLULAR CARCINOMA显示文摘 | Felicia L.‐S.Tan Yu‐MengTan Alexander Y.‐F.Chung Peng C.Cheow Pierce K.‐H.Chow London L.Ooi | 2006 | ANZ Journal of Surgery2006，，6： | 2 |
| 20 | A processual analysis of knowledge transfer: From foreign MNEs to Chinese suppliers显示文摘 | Jing-Lin Duanmu Felicia M. Fai | 2007 | International Business Review2007，，4： | 2 |
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