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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | First characterization of endophytic Corynespora cassiicola isolates with variant cassiicolin genes recovered from rubber trees in Brazil显示文摘Corynespora cassiicola is the causal agent of Corynespora Leaf Fall(CLF)disease.CLF is one of the most important fungal diseases of rubber trees in Asia and Africa but disease outbreaks have not been reported in South America.Cassiicolin,a small cysteine-rich glycoprotein secreted by the pathogenic C.cassiicola isolate CCP,was previously identified as a potential disease effector in rubber tree.Recently,the cassiicolin-encoding gene(Cas1)was characterized and shown to be expressed in the early phase of infection.In this study,we investigated whether previously undetected strains of C.cassiicola are present in South American rubber plantations by examining the fungal endophyte population found in asymptomatic rubber tree leaves.Four isolates were identified as C.cassiicola.Genes encoding new forms of the cassiicolin precursor protein(Cas3 and Cas4)were identified from these isolates.Three of four isolates were able to induce symptoms on the cultivar they were isolated from in a detached leaf assay,with different kinetics and intensities.One isolate had the same pathogenicity profile as the pathogenic isolate CCP;the other two isolates developed symptoms late during the course of infection,suggesting saprotrophic capabilities.However,no Cas3 or Cas4 transcripts could be detected upon inoculation with the endophytic isolates,whereas the reference gene Cas1 was expressed upon inoculation with the CCP isolate.This work demonstrated that C.cassiicola is present in South America in an endophytic form and that it may evolve from an endophytic to a saprophytic or even potentially pathogenic life style. | Marine Déon Ana Scomparin Aude Tixier Carlos R.R.Mattos Thierry Leroy Marc Seguin Patricia Roeckel-Drevet Valérie Pujade-Renaud | 2012 | Fungal Diversity2012，，3： | 2 |
| 3 | Photo emission and photoionization measurements in the CO2 laser environment显示文摘 | Seguin H J J Mcken D Tulip J | 1976 | Appl Phys Lett1976，28，9： | 1 |
| 4 | Associations between sleep duration patterns and behavioral/cognitive functioning at school entry显示文摘 | Touchette E Petit D Seguin JR | 2007 | Sleep2007，30，9： | 1 |
| 5 | Physical aggression during early childhood:Trajectories and predictors显示文摘 | TREMBLAY R E NAGIN D S SEGUIN J R | | 0，，01： | 1 |
| 6 | Consumer reactions to product placement strategies in television sponsorship 显示文摘 | d' Astous A Seguin N | 1999 | European Journal of Marketing1999，33，910： | 1 |
| 7 | Surface temperature and vapor transpiration: application of local scale methods to regional scales using satellite data 显示文摘 | Seguin B Courault D Guerif M | 1994 | Remote Sens Environ1994，，49： | 1 |
| 8 | New type of schottky barriers using NiTi shape memory alloy filme显示文摘 | Bendahan M Seguin J LoUman D | 1996 | Thin Solid Films1996，294，1： | 1 |
| 9 | Formation of a nu- cleus pulposus-cartilage endplate construct in vitro 显示文摘 | Hamilton D J Seguin C A Wang J | 2006 | Bio- materials2006，27，3： | 1 |
| 10 | Ginkgo biloba extract (EGb 761) pretreatment limits free radical- induced oxidative stress in patients undergoing coronary bypass surgery 显示文摘 | Pieui S Seguin JR D' Arbigny P Drieu K Culcasi M | 1997 | Cardiovasc Drugs Ther1997，11，： | 1 |
| 11 | Methicillin-resistant Staphylococcus aureus outbreak in a veterinary teaching hospital: potential human to animal transmission显示文摘 | Seguin J C Walker R D Caron J P | 1999 | Journal of Clinical Microbiology1999，37，： | 1 |
| 12 | Experimental Characterization of Flow Regimes in Various Porous Media-Ⅰ:Limit of Laminar Flow Regime显示文摘 | Montillet A Comiti J | 1998 | Chemical Engineering Science1998，53，21： | 1 |
| 13 | Experimental Characterization of flow Regimes in Various Porous Microsoftedia-Ⅱ:Transition to Turbulent Regime显示文摘 | Montillet A Comiti J | 1998 | Chemical Engineering Science1998，53，22： | 1 |
| 14 | Ginkgo biloba extract (Egb) pretreatment limits free radical-induced oxidative stress in patients undergoing coronary bypass surgery显示文摘 | Pietri S Seguin JR d'Arbigny P | 1997 | Cardiovasc Drugs Ther1997，11，2： | 1 |
| 15 | The - 33T- - 》C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembo显示文摘 | Ameziane N Seguin C Borgel D | 2002 | Thromb Haemost2002，88，2： | 1 |
| 16 | Review on estimation of evapotranspiration from remote sensing data : From empirical to numerical modeling approaches显示文摘 | Courault D Seguin B Olioso A | 2005 | Irrigation and Drainage Systems2005，19，： | 1 |
| 17 | 14-3-3 gene family in hybrid poplar and its involvement in tree defence against pathogens显示文摘 | Lapointe G Luckevich M D Cloutier M Seguin A | 2001 | Exp Bot2001，52，359： | 1 |
| 18 | Cognitive- neuropsychological function in chronic physical ag- gression and hyperactivity 显示文摘 | Seguin JR Nagin D Assaad JM | 2004 | Journal of Abnormal Psychology2004，113，4： | 1 |
| 19 | New type of schottky barriers using NiTi shape memory alloy films显示文摘 | Bendahan M Seguin J L Lollman D at el | 1997 | Thin Solid Films1997，294，12： | 1 |
| 20 | Comparison of plan- tar pressures and contact area between normal and cavus foot显示文摘 | Fernandez - Seguin L M Mancha J A D Rodriguez RS | 2014 | Gait Posture2014，39，2： | 1 |
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