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| 1 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 2 | Endoscopic and radiographic features of gastrointestinal involvement in vasculitis显示文摘Vasculitis is an inflammation of vessel walls,followed by alteration of the blood flow and damage to the dependent organ.Vasculitis can cause local or diffuse pathologic changes in the gastrointestinal (GI) tract.The variety of GI lesions includes ulcer,submucosal edema,hemorrhage,paralytic ileus,mesenteric ischemia,bowel obstruction,and life-threatening perforation.The endoscopic and radiographic features of GI involvement in vasculitisare reviewed with the emphasis on small-vessel vasculitis by presenting our typicalcases,including Churg-Strauss syndrome,HenochSch nlein purpura,systemic lupus erythematosus,and Beh et's disease.Important endoscopic features are ischemic enterocolitis and ulcer.Characteristic computed tomographic findings include bowel wall thickening with the target sign and engorgement of mesenteric vessels with comb sign.Knowledge of endoscopic and radiographic GI manifestations can help make an early diagnosis and establish treatment strategy. | Akira Hokama Kazuto Kishimoto Yasushi Ihama Chiharu Kobashigawa Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Futoshi Higa Masao Tateyama Fukunori Kinjo Kunitoshi Iseki Seiya Kato Jiro Fujita | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 9 |
| 3 | 胃肠的淀粉样变性病的内视镜、组织病理学说的特征显示文摘 Amyloidosis is a rare disorder, characterized by the extracellular deposition of an abnormal fibrillar protein, which disrupts tissue structure and function. Amyloidosis can be acquired or hereditary, and systemic or localized to a single organ, such as the gastrointestinal (GI) tract. Clinical manifestations may vary from asymptomatic to fatal forms. Primary amyloidosis (monoclonal immunoglobulin light chains, AL) is the most common form of amyloidosis. AL amyloidosis has been associated with plasma cell dyscrasias, such as, mul- tiple myeloma. Secondary amyloidosis is caused by the deposition of fragments of the circulating acute-phase reactant, serum amyloid A protein (SAA). Common causes of AA amyloidosis are chronic inflammatory dis-orders. Although GI symptoms are usually nonspecific, histopathological patterns of amyloid deposition are associated with clinical and endoscopic features. Amyloid deposition in the muscularis mucosae, submucosa, and muscularis propria has been dominant in AL amyloidosis, leading to polypoid protrusions and thickening of the valvulae conniventes, whereas granular amyloid deposition mainly in the propria mucosae has been related to AA amyloidosis, resulting in the fine granular appearance, mucosal friability, and erosions. As a result, AL amyloidosis usually presents with constipation, mechanical obstruction, or chronic intestinal pseudoobstruction while AA amyloidosis presents with diarrhea and malabsorption Amyloidotic GI symptoms are mostly refractory and have a negative impact on quality of life and survival. Diagnosing GI amyloidosis requires high suspicion of evaluating endoscopists. Because of the absence of specific treatments for reducing the abundance of the amyloidogenic precursor protein, we should be aware of certain associations between patterns of amyloid deposition and clinical and endoscopic features. | Akira Hokama Kazuto Kishimoto Manabu Nakamoto Chiharu Kobashigawa Tetsuo Hirata Nagisa Kinjo Fukunori Kinjo Seiya Kato Jiro Fujita | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，8： | 6 |
| 4 | Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer显示文摘AIM:To investigate the immunological repertoire in the peritoneal cavity of gastric cancer patients.METHODS:The peritoneal cavity is a compartment in which immunological host-tumor interactions can occur.However,the role of lymphocytes in the peritoneal cavity of gastric cancer patients is unclear.We observed 64 patients who underwent gastrectomy for gastric cancer and 11 patients who underwent laparoscopic cholecystectomy for gallstones and acted as controls.Lymphocytes isolated from both peripheral blood and peritoneal lavage were analyzed for surface markers of lymphocytes and their cytokine production by flow cytometry.CD4+CD25high T cells isolated from the patient's peripheral blood were co-cultivated for 4 d with the intra-peritoneal lymphocytes,and a cytokine assay was performed.RESULTS:At gastrectomy,CCR7 -CD45RA-CD8+ef-fector memory T cells were observed in the peritoneal cavity.The frequency of CD4+CD25 high T cells in both the peripheral blood and peritoneal cavity was elevated in patients at advanced stage[control vs stage Ⅳin the peripheral blood:6.89(3.39-10.4)vs 15.34(11.37-19.31),P<0.05,control vs stageⅣin the peritoneal cavity:8.65(5.28-12.0)vs 19.56(14.81-24.32),P<0.05].On the other hand,the suppression was restored with CD4+CD25high T cells from their own peripheral blood.This study is the first to analyze lymphocyte and cytokine production in the peritoneal cavity in patients with gastric cancer.Immune regulation at advanced stage is reversible at the point of gastrectomy.CONCLUSION:The immunological milieu in the peritoneal cavity of patients with advanced gastric cancer elicited a Th2 response even at gastrectomy,but this response was reversible. | Akira Yoneda Shinichiro Ito Seiya Susumu Mitsutoshi Matsuo Ken Taniguchi Yoshitsugu Tajima Susumu Eguchi Takashi Kanematsu Yasuhiro Nagata | 2012 | World Journal of Gastroenterology2012，18，13： | 5 |
| 5 | Fabrication of TiAl 3 coating on TiAl-based alloy by Al electrodeposition from dimethylsulfone bath and subsequent annealing显示文摘 | Masao Miyake Seiya Tajikara Tetsuji Hirato | 2011 | Surface & Coatings Technology2011，，21： | 2 |
| 6 | CD44v6 expression is related to mesenchymal phenotype and poor prognosisin patients with colorectal cancer显示文摘 | Seiya Saito Hirohisa Okabe Masayuki Watanabe Takatsugu Ishimoto Masaaki Iwatsuki Yoshifumi Baba Youhei Tanaka Junji Kurashige Yuji Miyamoto Hideo Baba | 2013 | Oncology Reports2013，，4： | 2 |
| 7 | Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes显示文摘 | Sho-ichi Yamagishi Sayaka Maeda Takanori Matsui Seiji Ueda Kei Fukami Seiya Okuda | 2011 | BBA - General Subjects2011，，5： | 2 |
| 8 | MicroRNA-200b Regulates Cell Proliferation, Invasion, and Migration by Directly Targeting ZEB2 in Gastric Carcinoma显示文摘 | Junji Kurashige Hidenobu Kamohara Masayuki Watanabe Yukiharu Hiyoshi Masaaki Iwatsuki Youhei Tanaka Koichi Kinoshita Seiya Saito Yoshifumi Baba Hideo Baba | 2012 | Annals of Surgical Oncology2012，，3： | 1 |
| 9 | Small bowel anisakiosis: A report of two cases显示文摘小肠狭窄是肠的 anisakiosis 的严肃的复杂并发症。这份报告的目的是调查小肠的严重狭窄是否能保存地被管理。我们与 anisakiosis 引起的小肠的严重狭窄对待二个病人。外科的干预最后被执行在上第 23 和第 35 在医院里分别地。 resected 标本的组织病理学说的检查表明肠的墙被 anisakiosis 的炎性反应完全损坏了,并且损坏是不可逆的,从而建议那剖腹术在严重的小肠狭窄的情况下被需要由肠的 anisakiosis 引起了,就算为肠的 anisakiosis 的保守疗法的一个长时期允许病人通过尖锐阶段成功地过去。 | Shigetoshi Matsuo Takashi Azuma Seiya Susumu Satoshi Yamaguchi Shirou Obata Tomayoshi Hayashi | 2006 | World Journal of Gastroenterology2006，12，25： | 1 |
| 10 | Non-invasive blood glucose measurement by Fourier transform infrared spectroscopic analysis through the mucous membrane of the lip:application of a chalcogenide optical fiber system显示文摘 | Takero Uemura Kenro Nishida Michiharu Sakakida Kenshi Ichinose Seiya Shimoda Motoaki Shichiri | 1999 | Frontiers of medical and biological engineering1999，9，2： | 1 |
| 11 | Identification and functional characterization of the trigeminal ventral cervical reflex pathway in the swine 显示文摘 | Seiya K Nicholas P Yoshio C | 2003 | Clinical Neurophysiology2003，114，： | 1 |
| 12 | Numerical simulation of dam break flow impact on vertical cylinder by cumulant lattice Boltzmann method显示文摘The purpose of this study is to apply the cumulant lattice Boltzmann method(LBM)to simulate high Reynolds number free surface flows.The single-phase cumulant LBM is extended to solve the free surface flows by using the phase-field method as the interface capturing scheme.Numerical simulations are performed on an experimental problem of dam break flow impact on a vertical cylinder.Important numerical aspects such as collision model,grid resolution,time step and interface mobility parameter are investigated.It is found that the severe impact pressure oscillation in the simulation by the conventional SRT model,can be significantly suppressed by the cumulant model.Good agreement between the cumulant LBM numerical simulation and the experiment has been obtained on both the free surface profiles and the impact pressures.The numerical results obtained by the present study demonstrate that the cumulant LBM can be a powerful numerical tool for simulations of violent free surface flow problems. | Seiya Watanabe Shintaro Fujisaki Changhong Hu | 2021 | Journal of Hydrodynamics2021，33，2： | 1 |
| 13 | Etiological factors in primary hepatic B-cell lymphoma显示文摘 | Kanta Kikuma Jiro Watanabe Yumi Oshiro Tatsuo Shimogama Yumi Honda Seiichi Okamura Koichi Higaki Naokuni Uike Tetsuro Soda Seiya Momosaki Tadaaki Yokota Satoshi Toyoshima Morishige Takeshita | 2012 | Virchows Archiv2012，，4： | 1 |
| 14 | Construction of various mutants of xylose metabolizing enzymes for efficient conversion of biomass to ethanol显示文摘 | Ahmed Abu Saleh Seiya Watanabe Narayana Annaluru | 2006 | Nucleic Acids Symposium2006，50，： | 1 |
| 15 | Preparation of poly(methyl methacrylate) macromonomer by radical polymerization in the presence of methyl α-(bromomethyl)acrylate and copolymerization of the resultant macromonomer显示文摘 | Bunichiro Yamada Eiichi Kato Seiya Kobatake Takayuki Otsu | 1991 | Polymer Bulletin1991，，4： | 1 |
| 16 | Recurrent yolk sac tumor following resection of a neonatal immature gastric teratoma显示文摘 | Etsuji Ukiyama Masao Endo Fumiko Yoshida Tohru Tezuka Kyoko Kudo Seiji Sato Seiya Akatsuka Jun-ichi Hata | 2005 | Pediatric Surgery International2005，，7： | 1 |
| 17 | MicroRNA-200b Regulates Cell Proliferation, Invasion, and Migration by Directly Targeting ZEB2 in Gastric Carcinoma显示文摘 | Junji Kurashige MD Hidenobu Kamohara MD PhD Masayuki Watanabe MD PhD Yukiharu Hiyoshi MD PhD Masaaki Iwatsuki MD PhD Youhei Tanaka MD Koichi Kinoshita MD Seiya Saito MD Yoshifumi Baba MD Hideo Baba MD PhD FACS | 2012 | Annals of Surgical Oncology2012，，3： | 1 |
| 18 | Two-bundle reconstruction of the anterior cruciate ligament using semitendinosustendon with endobuttons:operative technique and preliminary results显示文摘 | Muneta T Seiya I Yagishita K | | 0，，： | 1 |
| 19 | Photosynthetic bioelectrochemical cell utilizing cyanobacteria and water-genexating oxidase显示文摘 | Seiya Tsujimura Aldra Wadano Kenji Kano | 2001 | Enzyme and Microbial Technology2001，29，： | 1 |
| 20 | Significance of mucin expression in pancreatobiliary neoplasms显示文摘 | Suguru Yonezawa Michiyo Higashi Norishige Yamada Seiya Yokoyama Masamichi Goto | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，2： | 1 |
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