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| 1 | CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis显示文摘Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from surgery.Methods: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December 2012.These patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate analyses.Results: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL. | Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka Ikeda Mitsugu Sekimoto Shoji Nakamori | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 4 |
| 2 | Minute liver metastases from a rectal carcinoid: A case report and review显示文摘We here report a 43-year-old male patient with minute liver metastases from a rectal carcinoid.Hepatic nodules were diagnosed during surgery,although they were not diagnosed by preoperative computed tomography or ultrasound examination.The rectal carcinoid was resected together with liver metastases and the patient has had no disease recurrence for 5 years following postoperative treatment of hepatic arterial infusion chemotherapy(HAIC) using 5-fluorouracil(5-FU)and oral administration of 1-hexylcarbamoyl-5-fluorouracil(HCFU).In 2003,a health check examination indicated presence of occult blood in his stool.Barium enema study revealed a rectal tumor in the lower rectum and colonoscopy showed a yellowish lesion with a size of 30 mm in diameter.Pathological examination of the biopsy specimen indicated that the rectal tumor was carcinoid.Although preoperative imaging examinations failed to detect liver metastases,2 min nodules were found on the surface of liver during surgery.A rapid pathological examination revealed that they were metastatic tumors from the rectal carcinoid.Low anterior resection was performed for the rectal tumor and the pathological report indicated that there were 4 metastatic lymph nodes in the rectal mesentery.The patient received treatment by HAIC using 5-FU plus oral administration of HCFU and survived for 5 years.We also review world-wide current treatments and their efficacy for hepatic metastases of carcinoid tumors. | Hirofumi Yamamoto Hideyuki Hemmi Mitsugu Sekimoto Yuichiro Doki Masaki Mori | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 3 |
| 3 | Reversed portal flow: Clinical influence on the long-term outcomes in cirrhosis显示文摘AIM: To elucidate the natural history and the longitudinal outcomes in cirrhotic patients with non-forward portal flow(NFPF).METHODS: The present retrospective study consisted of 222 cirrhotic patients(120 males and 102 females; age, 61.7 ± 11.1 years). The portal hemodynamics were evaluated at baseline and during the observation period using both pulsed and color Doppler ultrasonography. The diameter(mm), flow direction, mean flow velocity(cm/s), and mean flow volume(m L/min) were assessed at the portal trunk, the splenic vein, the superior mesenteric vein, and the collateral vessels. The average values from 2 to 4 measurements were used for the data analysis. The portal flow direction was defined as follows: forward portal flow(FPF) for continuous hepatopetal flow; bidirectional flow for to-and-fro flow; and reversed flow for continuous hepatofugal flow. The bidirectional flow and the reversed flow were classified as NFPF in this study. The clinical findings and prognosis were compared between the patients with FPF and those with NFPF. The median follow-up period was 40.9 mo(range, 0.3-156.5 mo).RESULTS: Twenty-four patients(10.8%) demonstrated NFPF, accompanied by lower albumin level, worse ChildPugh scores, and model for end-stage liver disease scores. The portal hemodynamic features in the patients with NFPF were smaller diameter of the portal trunk;presence of short gastric vein, splenorenal shunt, or inferior mesenteric vein; and advanced collateral vessels(diameter > 8.7 mm, flow velocity > 10.2 cm/s, and flow volume > 310 m L/min). The cumulative incidence rates of NFPF were 6.5% at 1 year, 14.5% at 3 years, and 23.1% at 5 years. The collateral vessels characterized by flow velocity > 9.5 cm/s and those located at the splenic hilum were significant predictive factors for developing NFPF. The cumulative survival rate was significantly lower in the patients with NFPF(72.2% at 1 year, 38.5% at 3 years, 38.5% at 5 years) than in those with forward portal flow(84.0% at 1 year, 67.8% at 3 years, 54.3% at 5 years, P = 0.0123) using the Child-Pugh B and C classifications.CONCLUSION: NFPF has a significant negative effect on the prognosis of patients with worse liver function reserve, suggesting the need for careful management. | Takayuki Kondo Hitoshi Maruyama Tadashi Sekimoto Taro Shimada Masanori Takahashi Osamu Yokosuka | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 4 | JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis显示文摘 | Miho Sekimoto Tadahiro Takada Yoshifumi Kawarada Koichi Hirata Toshihiko Mayumi Masahiro Yoshida Masahiko Hirota Yasutoshi Kimura Kazunori Takeda Shuji Isaji Masaru Koizumi Makoto Otsuki Seiki Matsuno | 2006 | Journal of Hepato-Biliary-Pancreatic Surgery2006，，： | 2 |
| 5 | JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis显示文摘 | Miho Sekimoto Tadahiro Takada Yoshifumi Kawarada Koichi Hirata Toshihiko Mayumi Masahiro Yoshida Masahiko Hirota Yasutoshi Kimura Kazunori Takeda Shuji Isaji Masaru Koizumi Makoto Otsuki Seiki Matsuno | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，1： | 2 |
| 6 | Heat coma as an indicator of resistance to environmental stress and its relationship to ocean dynamics in the sea skaters, Halobates (Heteroptera: Gerridae)显示文摘到温度增加的忍耐为在西方的热带太平洋在二巡航期间收集的 Halobates 个人被测试(MR-06-05-Leg 3, 12 月 21 日, 2006January 12, 2007, 0 搠浥湡吗? | Tetsuo Harada Shiho Takenaka Takero Sekimoto Mitsuru Nakajyo Takao Inoue Takamasa Ishibashi Chihiro Katagiri | 2011 | Insect Science2011，18，6： | 2 |
| 7 | Isolation and molecular characterization of a Spotted leaf 18 mutant by modified activation-tagging in rice显示文摘 | Masaki Mori Chikako Tomita Kazuhiko Sugimoto Morifumi Hasegawa Nagao Hayashi Joseph G. Dubouzet Hirokazu Ochiai Hitoshi Sekimoto Hirohiko Hirochika Shoshi Kikuchi | 2007 | Plant Molecular Biology2007，，6： | 2 |
| 8 | Percutan-eous radio-frequency thermocoagulation of the Gasserian ganglion guided by high-speed real-time CT fluoroscopy显示文摘 | Koizuka S Saito S Sekimoto K | | 0，，： | 1 |
| 9 | Volatilization of Nitrogen Compounds from Rice Leaf显示文摘 | SEKIMOTO H KUMAZAWA K | 1985 | Japan J Soil Sci Plant Nutr1985，56，： | 1 |
| 10 | A mobile-phone based sys- tem for the elderly显示文摘 | Tamura T Masuda Y Sekimoto M | 2004 | Conf Proc IEEE Eng Med Biol Soc2004，5，： | 1 |
| 11 | Diameter for portal of splenie vein is a risk factor or splenic vein thrombosis after laparoscopic splenectomy显示文摘 | Darmo K Ikeda M Sekimoto M etal | 2009 | Surgery2009，145，5： | 1 |
| 12 | Totally laparoscopic distal gastrectomy using the hand-semn Billroth-Ⅰ anastomotic technique:report of a case 显示文摘 | Takiguchi S Sekimoto M Miyake Y | 2003 | Surg Today2003，33，： | 1 |
| 13 | The Origin of Volatilized Nitrogen Compounds from Rice Leaf显示文摘 | SEKIMOTO H ARIMA Y KUMAZAWA K | 1985 | Japan J Soil Sci Plant Nutr1985，56，： | 1 |
| 14 | Clinical rele- vance of fusion images using sF-2-fluoro 2-deoxy-D-glucose positron emission tomography in local recurrence of rectal cancer显示文摘 | Fukunage H Sekimoto M Tatsumi M | 2002 | Int J Oncol2002，20，4： | 1 |
| 15 | Tracing the movement of adiponectin in a parabiosis model of wild-type and adiponectin-knockout mice显示文摘 | Nakatsuji H Kishida K Sekimoto R | 2014 | FEBS Open Bio2014，4，： | 1 |
| 16 | A case of local recurrence of rectal cancer that achieved a complete response with high-dose interstitial brachytherapy显示文摘 | Monden T Tomita | 1997 | Gan To Kagaku Ryoho1997，24，12： | 1 |
| 17 | Overexpres-sion of CDC25B phosphatase as a novel marker of poor prognosis human colorectal carcinoma显示文摘 | Takemasa I Yamamoto H Sekimoto M | 2000 | Cancer Res2000，60，11： | 1 |
| 18 | Crystalli- zation and melting of polyisoprene rubber under uniaxial de- formation 显示文摘 | Yoshihisa Miyamoto Hiromi Yamao Ken Sekimoto | 2003 | Macromolecules2003，36，17： | 1 |
| 19 | JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis显示文摘 | Sekimoto M Takada T Kawarada Y | 2006 | J Hepatobiliary Pancreat Surg2006，13，1： | 1 |
| 20 | Early detection of non-palpable (T0) breast cancer: the diagnostic procedure for pathological discharge from the nipple 显示文摘 | Yayoi E Furukawa J Sekimoto M | 1994 | Gan To Kagaku Ryoho1994，21，2： | 1 |
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