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| 1 | A comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma显示文摘AIM:To compare the clinical outcome and pathologic features of non-alcoholic steatohepatitis(NASH) patients with hepatocellular carcinoma(HCC) and hepatitic C virus(HCV) patients with HCC(another group in which HCC is commonly seen) undergoing liver transplantation.METHODS:Patients transplanted for HCV and NASH at our institution from January 2000 to April 2011 were analyzed.All explanted liver histology and pre-transplant liver biopsies were examined by two specialist liver histopathologists.Patient demographics,disease free survival,explant liver characteristics and HCC features(tumour number,cumulative tumour size,vascular invasion and differentiation) were compared between HCV and NASH liver transplant recipients.RESULTS:A total of 102 patients with NASH and 283 patients with HCV were transplanted.The incidence of HCC in NASH transplant recipients was 16.7%(17/102).The incidence of HCC in HCV transplant recipients was 22.6%(64/283).Patients with NASH-HCC were statistically older than HCV-HCC patients(P < 0.001).A significantly higher proportion of HCV-HCC patients had vascular invasion(23.4% vs 6.4%,P = 0.002) and poorly differentiated HCC(4.7% vs 0%,P < 0.001) compared to the NASH-HCC group.A trend of poorer recurrence free survival at 5 years was seen in HCV-HCC patients compared to NASH-HCC who underwent a Liver transplantation(P = 0.11).CONCLUSION:Patients transplanted for NASH-HCC appear to have less aggressive tumour features compared to those with HCV-HCC,which likely in part accounts for their improved recurrence free survival. | Roberto Hernandez-Alejandro Kris P Croome Martin Drage Nathalie Sela Jeremy Parfitt Natasha Chandok Paul Marotta Cheryl Dale William Wall Douglas Quan | 2012 | World Journal of Gastroenterology2012，18，31： | 5 |
| 2 | Functional optoacoustic neuro-tomography for scalable whole-brain monitoring of calcium indicators显示文摘Non-invasive observation of spatiotemporal activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience.We developed a volumetric multispectral optoacoustic tomography platform for imaging neural activation deep in scattering brains.It can record 100 volumetric frames per second across scalable fields of view ranging between 50 and 1000 mm^(3) with respective spatial resolution of 35–200μm.Experiments performed in immobilized and freely swimming larvae and in adult zebrafish brains expressing the genetically encoded calcium indicator GCaMP5G demonstrate,for the first time,the fundamental ability to directly track neural dynamics using optoacoustics while overcoming the longstanding penetration barrier of optical imaging in scattering brains.The newly developed platform thus offers unprecedented capabilities for functional whole-brain observations of fast calcium dynamics;in combination with optoacoustics'well-established capacity for resolving vascular hemodynamics,it could open new vistas in the study of neural activity and neurovascular coupling in health and disease. | X Luís Deán-Ben Gali Sela Antonella Lauri Moritz Kneipp Vasilis Ntziachristos Gil G Westmeyer Shy Shoham Daniel Razansky | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 3 | The chemical Nature of an Antiviral Factor (AVF) from Virus infected Plants显示文摘 | Mozes Rita Antignus Y Sela I | 1978 | J Gen Virol1978，，38： | 1 |
| 4 | The Optimal Allocation of Prize in Contests显示文摘 | Moldovanu B Sela A | | American Economic Review0，91，3： | 1 |
| 5 | Evidence for the presence of bacteriain the blood of psoriasis patients显示文摘 | Munz O H Sela S Baker B S | 2010 | Arch Demmtol Res2010，302，7： | 1 |
| 6 | Elimination of grapevine virus A (GVA) by cryopreservation of in vit rogrown shoot tip s of Vitis vinifera L显示文摘 | WANG Q MAWAWASSI M LI P GAFNY R SELA I TANNE E | 2003 | Plant Sci2003，165，： | 1 |
| 7 | Localization and toxic effects of cadmium, copper and uranium in AzoUa显示文摘 | Sela M Tel-Or E Fritz E | 1988 | Plant Physiology1988，88，1： | 1 |
| 8 | Real-time haptic incision simulation using FEM-based discontinuous free-form deformation显示文摘 | SELA G SUBAG J LINDBLAD A | 2007 | Computer-Aided Design2007，39，8： | 1 |
| 9 | The optimal alloeation of pri- zes in contests显示文摘 | MOLDOVANU B SELA A | 2001 | The American Economic Review2001，91，3： | 1 |
| 10 | Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides显示文摘 | SELA D A MILLS D A | 2010 | Trends in Microbiology2010，18，7： | 1 |
| 11 | Inhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2显示文摘 | Ruth Maron Bilha Schechter Maicol Mancini Georg Mahlknecht Yosef Yarden Michael Sela | 2013 | Proceedings of the National Academy of Sciences2013，，38： | 1 |
| 12 | Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides 显示文摘 | Sela D A Mills D A | 2010 | Trends in Microbiology2010，18，7： | 1 |
| 13 | The secretion of PGE2,IL-1B,IL-B and TNF-α by adherent mononuclear cells from early onset periodontitis patients显示文摘 | Soskolne WA Sela MN | 1994 | J Periodontol1994，65，： | 1 |
| 14 | Antigenicity: some molecular aspects 显示文摘 | Sela M | 1969 | Science1969，166，911： | 1 |
| 15 | Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors显示文摘 | Klapper LN Kirschbaum MH Sela M | 2000 | Adv Cancer Res2000，77，1： | 1 |
| 16 | Contest architecture显示文摘 | MOLDOVANU B SELA A | 2006 | Jour nal of Economic Theory2006，126，1： | 1 |
| 17 | The reversible reduction of disulfide bonds in polyalanyl ribonuclease 显示文摘 | ANFINSEN C B SELA M COOKE J P | 1962 | J Biol Chem1962，237，： | 1 |
| 18 | Cytokinin but not gibberellin application had major impact on the phenylpropanoid pathway in grape显示文摘Cytokinin and gibberellic acid(GA)are growth regulators used to increase berry size in seedless grapes and it is of interest to understand their effects on the phenylpropanoid pathway and on ripening processes.GA 3 and synthetic cytokinin forchlorfenuron(N-(2-chloro-4-pyridyl)-N′-phenylurea,CPPU)and their combination were applied to 6 mm diameter fruitlets of‘Sable Seedless’,and berries were sampled 51 and 70 days(d)following application.All treatments increased berry size and delayed sugar accumulation and acid degradation with a stronger effect of CPPU.CPPU,but not GA,reduced berry color and the levels of anthocyanins.While CPPU reduced the levels of anthocyanins by more than 50%,the combined treatment of GA+CPPU reduced the levels by about 25%at 51 d.CPPU treatment had minor effects on flavonols content but increased the levels of monomeric flavan-3-ols by more than two-fold.Phloroglucinol analysis using HPLC showed that proanthocyanidin content was significantly increased by CPPU,whereas mean degree of polymerization was reduced from 26 to 19.Volatile analysis by GC-MS showed changes in composition with CPPU or GA treatment with potential impact on flavor.RNA-seq analysis showed that GA had a minor overall effect on the transcriptome whereas CPPU had pronounced effects on gene expression at both 51 and 70 d.Comparing the control and CPPU at similar Brix of ca.19.7°,a reduced expression of stilbene synthases(STSs)including their regulators MYB14 and MYB15,and other phenylpropanoid-related genes was observed in CPPU-treated grapes.Overall,our study shows that CPPU had a major influence on the phenylpropanoid pathway and affected multiple ripening-related processes. | Kamal Tyagi Itay Maoz Bettina Kochanek Noa Sela Larry Lerno Susan EEbeler Amnon Lichter | 2021 | Horticulture Research2021，8，1： | 1 |
| 19 | Structure and expression of the membrane proteoglycan betaglycan,acomponent of the TGF-βreceptor system显示文摘 | Fernando López-Casillas Sela Cheifetz Jacqueline Doody | 1991 | Cell1991，67，4： | 1 |
| 20 | Adherence of periodontopathic bacteria to bioabsorbable and non-absorbable barrier me-mbranes in vitro 显示文摘 | Sela MN Steinberg D Klinger A | 1999 | Clin Oral Implants Res1999，10，6： | 1 |
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