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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptorubiquitylation显示文摘Intracellular signals mediated by the family of receptor tyrosine kinases play pivotal roles in morphogenesis, cell fate determination and pathogenesis. Precise control of signal amplitude and duration is critical for the fidelity and robustness of these processes. Activation of receptor tyrosine kinases by their cognate growth factors not only leads to propagation of the signal through various biochemical cascades, but also sets in motion multiple attenuation mechanisms that ulti- mately terminate the active state. Early attenuators pre-exist prior to receptor activation and they act to limit signal propagation. Subsequently, late attenuators, such as Lrig and Sprouty, are transcriptionally induced and further act to dampen the signal. Central to the process of signaling attenuation is the role of the E3 ubiquitin ligase c-Cbl. While Cbl- mediated processes of receptor ubiquitylation and endocytosis are relatively well understood, the links of Cbl to other negative regulators are just now beginning to be appreciated. Here we review some emerging interfaces between Cbl and the transcriptionally induced negative regulators Lrig and Sprouty. | Chanan RUBIN Gal GUR Yosef YARDEN | 2005 | Cell Research2005，15，1： | 5 |
| 3 | The EGFR family and its ligands in human cancersignalling mechanisms and therapeutic opportunities显示文摘 | Yarden Y | 2001 | Eur J Cancer2001，37，4： | 1 |
| 4 | The ERBB network: at last, cancer therapy meets systems biology显示文摘 | Yarden Y Pines G | 2012 | Nat Rev Cancer2012，12，8： | 1 |
| 5 | Inhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2显示文摘 | Ruth Maron Bilha Schechter Maicol Mancini Georg Mahlknecht Yosef Yarden Michael Sela | 2013 | Proceedings of the National Academy of Sciences2013，，38： | 1 |
| 6 | Molecular mechanisms underlying ErbB2/ HER2 action in breast cancer 显示文摘 | Hararid D Yarden Y | 2000 | Oncogene2000，19，53： | 1 |
| 7 | Consistency test of the cell cycle : roles for p53 and EGR1 显示文摘 | Zwang Y Oren M Yarden Y | 2012 | Cancer Res2012，72，5： | 1 |
| 8 | Performance simulation pinpoints MSR oroblem显示文摘 | Yarden A L Main C W | 1996 | Power Engineering1996，100，12： | 1 |
| 9 | Neuregulins and their receptors : a versatile signaling module in organogenesis and oncogenesis 显示文摘 | Burden S Yarden Y | 1997 | Neuron1997，18，6： | 1 |
| 10 | BRCA 1 regulates the G2/M checkpoint by activating Chk 1 kinase upon DNA damage显示文摘 | Yarden RI Pardo-Reoyo S Sgagias M | 2002 | Nat Genet2002，30，3： | 1 |
| 11 | Asking Scientists: A Decade of Questions Ana- lyzed by Age, Gender and Country 显示文摘 | Baram-Tsabari A Sethi R J Bry L Yarden A | 2009 | Science Education2009，93，1： | 1 |
| 12 | Molecular mechanisms underlying ErbB2/ HER2 action in breast cancer显示文摘 | Hararid D Yarden Y | 2000 | Oncogene2000，19，53： | 1 |
| 13 | Mutations leading to substitutions at amino acids 198 and 200 of Beta-tubulin that correlate with benomyl-resistance phenotypes of field strains of Botrytis cinerea显示文摘 | Yarden O Katan T | 1993 | Phytopathology1993，83，12： | 1 |
| 14 | Untangling the ErbB signalling network显示文摘 | Yarden Y Sliwkowski MX | 2001 | Nat Rev Mol Cell Biol2001，2，2： | 1 |
| 15 | The involvement of polyphenols and peroxidase activities in heavy-metal accumulation by epidermal glands of the waterlily (Nymphaeaceae)显示文摘 | Lavid N Schwartz A Yarden O | 2001 | Planta2001，212，3： | 1 |
| 16 | Evidence for volatile chemical attractant in the beetle Maladera matrida Argaman(Coleoptera: Searabaeidae)显示文摘 | Yarden G Shani A | 1994 | Journal of Chemical Ecology1994，20，： | 1 |
| 17 | Using Questions Sent to an Ask-A-Scientist Site to Identify Children' s Interests in Science 显示文摘 | Baram-Tsabari A Sethi R J Bry L Yarden A | 2006 | Science Education2006，90，6： | 1 |
| 18 | Mutations leading to substitutions at amino acids 198 and 200 of beta-tubulin that correlate with benomyl-resistance phenotypes of field strains of Botrytis cinerea显示文摘 | Yarden O Katan T | 1993 | Phytopathology1993，83，： | 1 |
| 19 | Human proto-oncogene c-kit:a new cell surface receptor tyrosine kinase for an unidentified ligand显示文摘 | Yarden Y Kuang WJ Yang-Feng T | 1987 | EMBO Journal1987，6，： | 1 |
| 20 | Differential protein expres- sion in Colletotrichum acutatum: changes associated with reactive ox- ygen species and nitrogen starvation implicated in pathogenicity on strawberry显示文摘 | Brown SH Yarden Y Gallop N | 2008 | Mol Plant Pathol2008，9，2： | 1 |
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