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| 1 | Effects of Gastrodiae rhizoma on proliferation and differentiation of human embryonic neural stem cells显示文摘Objective:To investigate the effects of Gastrodiae rhizoma,a dried root of Gastrodia elata Blume,on proliferation and differentiation of human NSCs derived from embryonic stem cells.Methods:A 70%ethanol extract of Gastrodiae rhizoma(EEGR) was estimated with4-hydroxybenzyl alcohol as a representative constituent by HPLC.Results:MTT assay showed that the treatment with EEGR increased the viability of NSCs in growth media.Compared to contro1,EEGR increased the number of dendrites and denritic spines extended from a differentiated NSC.Whereas EEGR decreased the mRNA expression of Nestin,it increased that of Tuj1 and MAP2 in NSCs grown in differentiation media.Immunocytochemical analysis using confocal microscopy also revealed the increased expression of MAP2 in dendrites of EEGR-treated NSCs.Furthermore,EEGR decreased mRNA expression of Sox2 in NSCs grown even in growth media.Conclusions:In conclusion,our study demonstrates for the first time that EEGR induced proliferation and neuronal differentiation of NSCs,suggesting its potential benefits on NSC-based therapies and neuroregeneration in various neurodegenerative diseases and brain Injuries. | Samrat Baral Ramesh Pariyar Chi-Su Yoon Dong-Cheol Kim Jong-Min Yun Seok O Jang Sung Yeon Kim Hyuncheol Oh Youn-Chul Kim Jungwon Seo | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 2 |
| 2 | Effect of Boost Pressure on Thermal Stratification in HCCI Engine Using the Multi-zone Model显示文摘 | KWON O Seok LIM Ock Taeck | 2010 | Journal of Mechanical Science and Technology2010，24，1： | 1 |
| 3 | A comparative study of similarity measures for manufacturing cell for- mation 显示文摘 | Livetra O S Ribeiro J F F Seok S C | 2008 | Journal of Manufacturing Systems2008，，27： | 1 |
| 4 | 17beta-Estradiol induces vasorelaxation in a G-protein-coupled receptor 30-independent manner显示文摘 | Seok YM Jang EJ Reiser O | | 0，，： | 1 |
| 5 | Transparent and Robust audio watermarking with a new echo embedding technique显示文摘 | Oh H O Kim H W Seok J W | 2001 | Multimedia and Expo2001，，： | 1 |
| 6 | Chemiluminescence analyzer of NOx as a high-throughput screening tool in selective catalytic reduction of NO显示文摘 | Seok O K Woo S I | 2011 | Science and Technology of Advanced Materials2011，12，05： | 1 |
| 7 | One-step synthesis of TOP capped PbSe pyramidal nanocrystals 显示文摘 | KHANNA P K JUNK W GOKARNA A BAEG J O SEOK S I | 2006 | Material Chemistry and Physics2006，96，1： | 1 |
| 8 | IGFBP-3 regulates esophageal tumor growth through IGF dependent and independent mechanisms显示文摘 | Munenori T Seok HK Takaomi O | | 0，，04： | 1 |
| 9 | Outcome and predictors of mortality in patients requiring invasive mechanical ventilation due to acute respiratory failure while undergoing ambulatory chemotherapy for solid cancers显示文摘 | So Young Park So Yeon Lim Sang-Won Um Won-Jung Koh Man Pyo Chung Hojoong Kim O Jung Kwon Hye Kyeong Park Seok Jin Kim Young Hyuck Im Myung-Ju Ahn Gee Young Suh | 2013 | Supportive Care in Cancer2013，，6： | 1 |
| 10 | Synthesis and magnetic properties of a Fe-Ni alloy dispersed Al2O3 nano-composite powder prepared by a chemical method 显示文摘 | O H Sung-Tag Namkung Seok LEE J ai-Sung | 2002 | Mater Sci Lett2002，21，2： | 1 |
| 11 | A review of fabrication methods and applications of novel tailored microcapsules 显示文摘 | SEOK KWON O JANG J BAE J | 2013 | Current Organic Chemistry2013，17，1： | 1 |
| 12 | Cyclodextrin-Enhanced Electrokinetic Removal of Phenanthrene from a Model Clay Soil显示文摘 | Seok O Marka S Elizabethr C | 2000 | Environmental Science and Technology2000，34，： | 1 |
| 13 | Flux Observer with Online Tuning of Stator and Rotor Resistances for Induction Motors显示文摘 | Seok H J Kwang K O | | 0，，3： | 1 |
| 14 | Effect of boost pressure on ther- mal stratification in HCCI engine using the multi-zone model 显示文摘 | Kwon O Seok Lim Ock Taeck | 2010 | Journal of Mechanical Science and Technology2010，24，： | 1 |
| 15 | A three- phase switched reluctance motor with two-phase excitation显示文摘 | JIN W A SEOK G O JAE W M | 1999 | IEEE Trans on IA1999，35，5： | 1 |
| 16 | Comparison of cyto- kine expression in mesenchymal stem ceils from human pla- centa, cord blood, and bone marrow显示文摘 | Hwang J H Shim S S Seok O S | 2009 | J Korean Med Sei2009，24，4： | 1 |
| 17 | A comparative study of similarity measures for manufacturing cell formation显示文摘 | Livetra O S Ribeiro J F F Seok S C | 2008 | Journal of manufacturing systems2008，27，1： | 1 |
| 18 | The relationship be- tween cytokines and HPV-16, HPV-16 E6, E7, and high- risk HPV viral load in the uterine cervix 显示文摘 | Song S H Lee J K Seok O S | 2007 | Gynecol On- col2007，104，3： | 1 |
| 19 | A simple preparation method for spherical carbons and their anodic performance in lithium secondary batteries 显示文摘 | Jung K O Seok J Y Kim J H | 2004 | Journal of Power Sources2004，125，2： | 1 |
| 20 | Cytokinone expressi in placenta-derived mesenchymal stem cells in patients with pre- eclampsia and normal pregnancies显示文摘 | Hwang J H Lee M J Seok O S | 2010 | Cytokine2010，49，1： | 1 |
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