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| 1 | Hepatectomy vs radiofrequency ablation for colorectal liver metastasis:A propensity score analysis显示文摘AIM:To compare outcomes from radiofrequency ablation(RFA) and hepatectomy for treatment of colorectal liver metastasis(CRLM).METHODS:From January 2000 to December 2009,408 patients underwent curative intent treatment for CRLM.We excluded patients using the criteria:size of CRLM > 3 cm,number of CRLM ≥ 5,percutaneous RFA,follow-up period < 12 mo,double primary cancer,or treatment with both RFA and hepatectomy.We matched 51 patients who underwent RFA with 102 patients who underwent hepatectomy by propensity scores.RESULTS:The median follow-up period was 45 mo(range,12 mo to 158 mo).Hepatic recurrence was more frequent in the RFA than the hepatectomy group(P = 0.021) although extrahepatic recurrence curves were similar(P = 0.716).Survival curves of hepatectomy group were better than that of RFA for multiple,large(> 2 cm) CRLM(P = 0.034).However,survival curves were similar for single or small(≤ 2 cm) CRLM(P = 0.714,P = 0.740).CONCLUSION:Hepatectomy is better than RFA for the treatment of CRLM.However,RFA might be suitable for selected patients with single,small(≤ 2 cm) CRLM. | Huisong Lee Jin Seok Heo Yong Beom Cho Seong Hyeon Yun Hee Cheol Kim Woo Yong Lee Seong Ho Choi Dong Wook Choi | 2015 | World Journal of Gastroenterology2015，21，11： | 14 |
| 2 | Predicting tumor response after preoperative chemoradiation using clinical parameters in rectal cancer显示文摘AIM: To evaluate the clinical parameters and identify a better method of predicting pathological complete response (pCR). METHODS: We enrolled 249 patients from a database of 544 consecutive rectal cancer patients who underwent surgical resection after preoperative chemoradiation therapy (PCRT). A retrospective review of morphological characteristics was then performed to collect data regarding rectal examination findings. A scoring model to predict pCR was then created. To validate the ability of the scoring model to predict complete regression.RESULTS: Seventy patients (12.9%) achieved a pCR. A multivariate analysis found that pre-CRT movability (P = 0.024), post-CRT size (P = 0.018), post-CRT morphology (P = 0.023), and gross change (P = 0.009) were independent predictors of pCR. The accuracy of the scoring model was 76.8% for predicting pCR with the threshold set at 4.5. In the validation set, the accuracy was 86.7%. CONCLUSION: Gross changes and morphological findings are important predictors of pathological response. Accordingly, PCRT response is best predicted by a combination of clinical, laboratory and metabolic information. | Chan Ho Park Hee Cheol Kim Yong Beom Cho Seong Hyeon Yun Woo Yong Lee Young Suk Park Doo Ho Choi Ho-Kyung Chun | 2011 | World Journal of Gastroenterology2011，17，48： | 6 |
| 3 | Repeat hepatic resection in patients with colorectal liver metastases显示文摘AIM:To investigate the survival outcomes of secondaryhepatectomy for recurrent colorectal liver metastases(CRLM).METHODS:From October 1994 to December 2009,patients with CRLM who underwent surgical treatment with curative intent were investigated.Patients were divided into two groups:patients who underwent primary hepatectomy(Group 1)and those who underwent secondary hepatectomy for recurrent CRLM(Group 2).RESULTS:Survival and prognostic factors were analyzed.A total of 461 patients were included:406patients in Group 1 and 55 patients in Group 2.After a median 39-mo(range,3-195 mo)follow-up,there was a significant difference between Groups 1 and 2in terms of disease-free survival(P=0.029)although there was no significant difference in overall survival(P=0.206).Secondary hepatectomy was less effective in patients with multiple recurrent CRLM than primary hepatectomy for initial CRLM(P=0.008).Multiple CRLM and radiofrequency ablation therapy were poor prognostic factors of secondary hepatectomy in multivariate Cox regression analysis(P=0.006,P=0.004,respectively).CONCLUSION:Secondary hepatectomy for single recurrent CRLM is as effective as primary surgical treatment for single recurrent CRLM.However,secondary hepatectomy for multiple recurrent CRLM is less effective than that for single recurrent CRLM. | Huisong Lee Seong Ho Choi Yong Beom Cho Seong Hyeon Yun Hee Cheol Kim Woo Yong Lee Jin Seok Heo Dong Wook Choi Kyung Uk Jung Ho-Kyung Chun | 2015 | World Journal of Gastroenterology2015，21，7： | 4 |
| 4 | Tumor Localization for Laparoscopic Colorectal Surgery显示文摘 | Yong Beom Cho Woo Yong Lee Hae Ran Yun Won Suk Lee Seong Hyeon Yun Ho-Kyung Chun | 2007 | World Journal of Surgery2007，，7： | 2 |
| 5 | Clinical Outcomes of Hepatic Resection and Radiofrequency Ablation in Patients With Solitary Colorectal Liver Metastasis显示文摘 | Won-Suk Lee Seong Hyeon Yun Ho-Kyung Chun Woo Yong Lee Sung-Joo Kim Seong-Ho Choi Jin-Seok Heo Jae Won Joh Dongil Choi Seung-Hoon Kim Hyunchul Rhim Hyo-Keun Lim | 2008 | Journal of Clinical Gastroenterology2008，，8： | 1 |
| 6 | p53, BCL-2, and Ki-67 Expression According to Tumor Response After Concurrent Chemoradiotherapy for Advanced Rectal Cancer显示文摘 | Nam Kyu Kim Jae Kun Park Kang Yong Lee Woo IK Yang Seong Hyeon Yun JinSil Sung Jin Sik Min | 2001 | Annals of Surgical Oncology2001，，5： | 1 |
| 7 | Prognostic Comparison Between Mucinous and Nonmucinous Adenocarcinoma in Colorectal Cancer显示文摘 | Jong Seob Park Jung Wook Huh Yoon Ah Park Yong Beom Cho Seong Hyeon Yun Hee Cheol Kim Woo Yong Lee Ho-Kyung Chun | 2015 | Medicine2015，，15： | 1 |
| 8 | Pulmonary resection for metastases from colorectal cancer: prognostic factors and survival 显示文摘 | Lee Won -Suk Yun Seong Hyeon Chun Ho -Kyung | 2007 | Int J Colorec Dis2007，22，6： | 1 |
| 9 | An Alternative Pathway in Colorectal Carcinogenesis Based on the Mismatch Repair System and p53 Expression in Korean Patients with Sporadic Colorectal Cancer显示文摘 | Hyoung Ran Kim Hee Cheol Kim Hae-Ran Yun Seok Hyung Kim Cheol Keun Park Yong Beom Cho Seong Hyeon Yun Woo Yong Lee Ho-Kyung Chun | 2013 | Annals of Surgical Oncology2013，，12： | 1 |
| 10 | Matrix metalloproteinase-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer显示文摘 | Yong Beom Cho Woo Yong Lee Sang Yong Song Hee Jung Shin Seong Hyeon Yun Ho-Kyung Chun | 2007 | Human Pathology2007，，11： | 1 |
| 11 | Comparative study of transrectal ultrasonography, pelvic computerized tomography, and magnetic resonance imaging in preoperative staging of rectal cancer显示文摘 | Nam Kyu Kim Myung Jin Kim Seong Hyeon Yun Seung Kook Sohn Jin Sik Min | 1999 | Diseases of the Colon & Rectum1999，，6： | 1 |
| 12 | Curved cutter stapler vs. linear stapler in rectal cancer surgery: a pilot prospective randomized study显示文摘 | Won-Suk Lee Woo Yong Lee Ho-Kyung Chun Seong Hyeon Yun Yong Beom Cho Hae-Ran Yun | 2009 | International Journal of Colorectal Disease2009，，11： | 1 |
| 13 | Risk factors for the requirement of surgical or endoscopic interventions during chemotherapy in patients with uncomplicated colorectal cancer and unresectable synchronous metastases显示文摘 | Jung‐A Yun Yoonah Park Jung Wook Huh Yong Beom Cho Seong Hyeon Yun Hee Cheol Kim Woo Yong Lee Ho‐Kyung Chun | 2014 | Oncol2014，，7： | 1 |
| 14 | L ynch‐like syndrome: Characterization and comparison with EPCAM deletion carriers显示文摘 | So Young Kang Cheol Keun Park Dong Kyung Chang Jong Won Kim Hee Jung Son Yong Beom Cho Seong Hyeon Yun Hee Cheol Kim Moosik Kwon Kyoung‐Mee Kim | 2015 | Cancer2015，，7： | 1 |
| 15 | Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2显示文摘Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been established.In this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of PDAC.We found that N-WASP is markedly expressed in clinical patients with PDAC.Clinical analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile studies.Knockdown of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and EMT.We also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were modulated.Both N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic cancer.These results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer metastasis.These findings may aid in the development of therapeutic strategies against pancreatic cancer. | HYUNG SUN KIM YUN SUN LEE SEUNG MYUNG DONG HYO JUNG KIM DA EUN LEE HYEON WOONG KANG MYEONG JIN KIM JOON SEONG PARK | 2024 | Oncology Research2024，32，4： | 0 |
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