| 1 | Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo显示文摘小介入 RNA (siRNA ) 是一个吸引人的治疗学的候选人让顺序特定的基因 silencing 用小分子药对待不治之症。然而,它的有效细胞内部的交货仍然是挑战。这里,我们发展了一高度 biocompatible 荧光灯碳点(CD ) ,并且表明导致在 vitro 并且在 vivo 击倒的有效基因的一个功能的 siRNA 交货系统。我们发现 CD nanoparticles (NP ) 提高 siRNA 的细胞的举起,经由在肿瘤房间的 endocytosis,与低 cytotoxicity 和意外有免疫力的回答。在实时房间的荧光成像的实时学习证明 CD NP 有利地在细胞质本地化并且成功地在 12 h 以内释放 siRNA。而且,我们显著地表明那 CD 调停 NP 的 siRNA 交货沉默绿色荧光蛋白质(GFP ) 表示并且在肿瘤特定的治疗的一个乳癌房间异种皮移植鼠标模型禁止肿瘤生长。我们开发了启用同时的 bioimaging 和基因表示的有效 downregulation 的多功能的 siRNA 交货车辆,那为基因治疗显示出优秀潜力。 | Seongchan Kim Yuri Choi Ginam Park Cheolhee Won Young-Joon Park Younghoon Lee Byeong-Su Kim DaI-Hee Min | 2017 | Nano Research2017，10，2： | 3 |
| 3 | Paleo-shoreline changes in moraine dammed lake Khagiin Khar, Khentey Mountains, Central Mongolia显示文摘The formation and evolution of glacier moraine-dammed lakes are closely related to past glacier expansion and retreat. Geomorphic markers such as lacustrine terraces and beach ridges observed in these lakes provide important evidence for regional paleoenvironment reconstruction. We document the magnitude of paleo-shoreline fluctuations and timings of highstands of lake water by using cosmogenic 10Be surface exposure dating and optically stimulated luminescence(OSL) dating on samples collected from lacustrine sediment and bedrock strath in Lake Khagiin Khar. The lake was initially impounded by glacier moraine at the Global Last Glacial maximum(gLGM;21–19 ka), and the lake reached its maximum paleo-shoreline level of 1840 m at sea level(a.s.l.). At that time, the stored lake water amount was up to seven times greater and the surface area was three times larger than the present values. The paleolake experienced higher shoreline levels at 1832, 1822, and 1817 m a.s.l. and reached the present lake level after 0.4 ka. We interpret that decrease in the paleolake level was caused by spillover. The increase in melt water after the gLGM and the Late Glacial exceeded the storage threshold of the lake, and the paleolake water overflowed across the lowest drainage divides. The lake spilled over across the lowest bedrock ridge at 15.9 ± 0.6 ka, and the outlet was incised since that time at a rate of 3.72 ± 0.15 mm/yr. The initial stream of the Khiidiin Pass River was disturbed by LGM moraine damming and was rerouted into the present course running through moraine after the spillover at 15.9 ± 0.6 ka. | OH Jeong-Sik SEONG Yeong Bae HONG Seongchan YU Byung Yong | 2019 | Journal of Mountain Science2019，16，6： | 0 |
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