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| 1 | The cartilage matrisome in adolescent idiopathic scoliosis显示文摘The human spinal column is a dynamic,segmented,bony,and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility.Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.The most common developmental disorder of the spine is scoliosis,a lateral deformity in the shape of the spinal column.Scoliosis may be part of the clinical spectrum that is observed in many developmental disorders,but typically presents as an isolated symptom in otherwise healthy adolescent children.Adolescent idiopathic scoliosis(AIS)has defied understanding in part due to its genetic complexity.Breakthroughs have come from recent genome-wide association studies(GWAS)and next generation sequencing(NGS)of human AIS cohorts,as well as investigations of animal models.These studies have identified genetic associations with determinants of cartilage biogenesis and development of the intervertebral disc(IVD).Current evidence suggests that a fraction of AIS cases may arise from variation in factors involved in the structural integrity and homeostasis of the cartilaginous extracellular matrix(ECM).Here,we review the development of the spine and spinal cartilages,the composition of the cartilage ECM,the so-called'matrisome'and its functions,and the players involved in the genetic architecture of AIS.We also propose a molecular model by which the cartilage matrisome of the IVD contributes to AIS susceptibility. | Carol AWise Diane Sepich Aki Ushiki Anas MKhanshour Yared HKidane Nadja Makki Christina AGurnett Ryan SGray Jonathan JRios Nadav Ahituv Lila Solnica-Krezel | 2020 | Bone Research2020，8，1： | 5 |
| 2 | Etch pit characterization of CdTe and CdZnTe substrates for use in mercury cadmium telluride epitaxy显示文摘 | EVERSON W J ARD C K SEPICH J L | 1995 | J Electronic Materials1995，24，5： | 1 |
| 3 | Chemo- kine GPCR signaling inhibits β-catenin during zebrafish axis formation显示文摘 | Wu S Y Shin J Sepich D S Solnica-Krezel L | 2012 | PLoS Biol2012，10，10： | 1 |
| 4 | Cyclooxygenase-1- derived PGE2 promotes cell motility via the G-protein- coupled EP4 receptor during vertebrate gastrulation 显示文摘 | CHA Y I KIM S H SEPICH D | 2000 | Genes Dev2000，20，1： | 1 |
| 5 | Apelin and its receptor control heart field formation during zebrafish gastrulation显示文摘 | Zeng XX Wilm TP Sepich DS | 2007 | Dev Cell2007，12，3： | 1 |
| 6 | Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation 显示文摘 | Cha Y I Kim S Sepich D | 2006 | Gene Dev2006，20，： | 1 |
| 7 | Apelin and its receptor control heart field formation during zebrafish gastrulation显示文摘 | Zeng XX Wilm TP Sepich DS | 2007 | Dev Cell2007，12，3： | 1 |
| 8 | Apelin and its receptor controlheart field formation during zebrafish gastrulation显示文摘 | Zeng XX Wilm TP Sepich DS | 2007 | Dev Cell2007，12，3： | 1 |
| 9 | Apelin and its receptor control heart field formation during zebrafish gastrulation 显示文摘 | Zeng X X Wilm T P Sepich D S | 2007 | Dev Cell2007，12，3： | 1 |
| 10 | Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements 显示文摘 | MARLOW F TOPCZEWSKI J SEPICH D | 2002 | Curr Biol2002，12，11： | 1 |
| 11 | Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movements显示文摘 | Sepich DS Usmani M Pawlicki S | | 0，，3： | 1 |
| 12 | Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation显示文摘 | CHA Y I KIM S H SEPICH D | 2006 | Genes Dev2006，20，1： | 1 |
| 13 | Apelin and Its Receptor Control Heart Field Formation during Zebrafish Gastrulation显示文摘 | Xin-Xin I. Zeng Thomas P. Wilm Diane S. Sepich Lilianna Solnica-Krezel | 2007 | Developmental Cell2007，，3： | 1 |
| 14 | Etch pit characterization of CdTe and CdZnTe substrates for use in Mercury Cadmium Telluride Epitaxy显示文摘 | EVERSON W J ARD C K SEPICH J L | 1995 | Journal of Electronic Materials1995，24，5： | 1 |
| 15 | Apelin and its receptor control heart field formation during zebrafish gastrulation显示文摘 | Zeng XX Wilm TP Sepich DS | | 0，，： | 1 |
| 16 | Apelin and its receptor control heart field formation during zebrafish gastrulation显示文摘 | Zeng XX Wilm TP Sepich DS | 2007 | Dev Cell2007，12，3： | 1 |
| 17 | The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension 显示文摘 | Topczewski J Sepich DS Myers DC | 2001 | Dev Cell2001，1，2： | 1 |
| 18 | Apelin and its receptor control heart field formation during zebrafish gastrulation 显示文摘 | Zeng XX Wihn TP Sepich DS | 2007 | Dev Cell2007，12，39： | 1 |
| 19 | Etch Pit characterizations if CdTe and CdZnTe substates for Use in mercury cadmium telluride epitaxy显示文摘 | Eversion W J ARD C K Sepich J L | 1995 | Journal of Electronic Materials1995，24，5： | 1 |
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