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| 1 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 2 | Adult human mesenchymal stem cell as a target for neoplastic transformation 显示文摘 | Serakinci N Guldberg P Burns J S | 2004 | Oncogene2004，23，29： | 1 |
| 3 | Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells 显示文摘 | Simonsen JL Rosada C Serakinci N | 2002 | Nat2002，20，6： | 1 |
| 4 | Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells显示文摘 | Simonsen JL Rosada C Serakinci N | 2002 | Nat Biotechnol2002，20，6： | 1 |
| 5 | Adult human mesenchymal stem cell as a target for neoplastic trans formation显示文摘 | SERAKINCI N GULDBERG P BURNS J S | 2004 | Oncogene2004，23，29： | 1 |
| 6 | Telomere dy- namics in human mesenchymal stem cells after exposure to acute oxidative stress显示文摘 | Harbo M Koelvraa S Serakinci N | 2012 | DNA Repair (Amst)2012，11，9： | 1 |
| 7 | Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells显示文摘 | Simonsen JL Rosada C Serakinci N | | 0，，6： | 1 |
| 8 | Adult human mesenchymal stem cell as a target for neoplastic transformation 显示文摘 | SERAKINCI N GULDBERG P BURNS J S | 2004 | Oneogene2004，23，29： | 1 |
| 9 | Adult human mesenchymal stem cell as a target for neoplastic transfomation 显示文摘 | Serakinci N Guldberg P Burns JS | 2004 | Oncogene2004，23，29： | 1 |
| 10 | Adult human mesenchymal stem cell as a target for neoplastic transformation显示文摘 | Serakinci N Guldberg P Burns JS | 2004 | Oncogene2004，23，29： | 1 |
| 11 | Adult human mesenchymal stem cell as a target for neoplastic transformation 显示文摘 | Serakinci N Guldberg P Burns JS | 2004 | Oncogene2004，23，29： | 1 |
| 12 | Telomerase expression extend the proliferative life span and maintains the osteogenic potential of human bone marrow stromal cells显示文摘 | SIMONSEN J L ROSADA C SERAKINCI N | 2002 | Nat Biotechnol2002，20，6： | 1 |
| 13 | Adult human mesenchymal stem cell as a target for neoplastic transformation显示文摘 | SERAKINCI N GULDBERG P BURNS J S | 2004 | Oncogene2004，23，29： | 1 |
| 14 | Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells.显示文摘 | Simonsen JL Rosada C Serakinci N | | 0，，： | 1 |
| 15 | Adult human mesenchyreal stem cell as a target for neoplastic transformation 显示文摘 | Serakinci N Guldberg P Burns JS | 2004 | Oncogene2004，23，29： | 1 |
| 16 | Adult human mesenchymal stem cell as a target for neophtstic transformation显示文摘 | Serakinci N Guldberg P Burns J S | 2004 | Oncogene2004，23，29： | 1 |
| 17 | Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells显示文摘 | Simonsen JL Rosada C Serakinci N | 2002 | Nat Biotechnol2002，20，6： | 1 |
| 18 | Telomere and telomerase in mesenchymal stem cells显示文摘 | Serakinci N Graakjaer J Kolvraa S | 2008 | Biochimie2008，90，1： | 1 |
| 19 | Telomerase expression extends the prolifer active life span and maintains the osteogenic potential of human bone marrow stromal ceils 显示文摘 | Simonsen JL Rosada C Serakinci N | 2002 | Nat Biotechno12002，20，： | 1 |
| 20 | Telomerase expression Extends the proliferative life-span and maintains the osteogenicpotentialof human bone marrow stromalcells显示文摘 | Simonsen J L Rosada C Serakinci N | 2002 | Nat Biotechnol2002，20，6： | 1 |
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