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| 1 | Role of the Ilizarov non-free bone plasty in the management of long bone defects and nonunion: Problems solved and unsolved显示文摘BACKGROUND Ilizarov non-free bone plasty is a method of distraction osteogenesis using the Ilizarov apparatus for external fixation which originated in Russia and was disseminated across the world. It has been used in long bone defect and nonunion management along with free vascularized grafting and induced membrane technique. However, the shortcomings and problems of these methods still remain the issues which restrict their overall use.AIM To study the recent available literature on the role of Ilizarov non-free bone plasty in long bone defect and nonunion management, its problems and the solutions to these problems in order to achieve better treatment outcomes.METHODS Three databases(Pub Med, Scopus, and Web of Science) were searched for literature sources on distraction osteogenesis, free vascularized grafting and induced membrane technique used in long bone defect and nonunion treatment within a five-year period(2015-2019). Full-text clinical articles in the English language were selected for analysis only if they contained treatment results,complications and described large patient samples(not less than ten cases for congenital, post-tumor resection cases or rare conditions, and more than 20 cases for the rest). Case reports were excluded.RESULTS Fifty full-text articles and reviews on distraction osteogenesis were chosen.Thirty-five clinical studies containing large series of patients treated with this method and problems with its outcome were analyzed. It was found that distraction osteogenesis techniques provide treatment for segmental bone defects and nonunion of the lower extremity in many clinical situations, especially in complex problems. The Ilizarov techniques treat the triad of problems simultaneously(bone loss, soft-tissue loss and infection). Management of tibial defects mostly utilizes the Ilizarov circular fixator. Monolateral fixators are preferable in the femur. The use of a ring fixator is recommended in patients with an infected tibial bone gap of more than 6 cm. High rates of successful treatment were reported by the authors that ranged from 77% to 100% and depended on the pathology and the type of Ilizarov technique used. Hybrid fixation and autogenous grafting are the most applicable solutions to avoid after-frame regenerate fracture or deformity and docking site nonunion.CONCLUSION The role of Ilizarov non-free bone plasty has not lost its significance in the treatment of segmental bone defects despite the shortcomings and treatment problems encountered. | Dmitry Y Borzunov Sergei N Kolchin Tatiana A Malkova | 2020 | World Journal of Orthopedics2020，11，6： | 13 |
| 2 | Ilizarov bone transport combined with the Masquelet technique for bone defects of various etiologies (preliminary results)显示文摘BACKGROUND The Ilizarov bone transport(IBT)and the Masquelet induced membrane technique(IMT)have specific merits and shortcomings,but numerous studies have shown their efficacy in the management of extensive long-bone defects of various etiologies,including congenital deficiencies.Combining their strong benefits seems a promising strategy to enhance bone regeneration and reduce the risk of refractures in the management of post-traumatic and congenital defects and nonunion that failed to respond to other treatments.AIM To combine IBT and IMT for the management of severe tibial defects and pseudarthrosis,and present preliminary results of this technological solution.METHODS Seven adults with post-traumatic tibial defects(subgroup A)and nine children(subgroup B)with congenital pseudarthrosis of the tibia(CPT)were treated with the combination of IMT and IBT after the failure of previous treatments.The mean number of previous surgeries was 2.0±0.2 in subgroup A and 3.3±0.7 in subgroup B.Step 1 included Ilizarov frame placement and spacer introduction into the defect to generate the induced membrane which remained in the interfragmental gap after spacer removal.Step 2 was an osteotomy and bone transport of the fragment through the tunnel in the induced membrane,its compression and docking for consolidation without grafting.The outcomes were retrospectively studied after a mean follow-up of 20.8±2.7 mo in subgroup A and 25.3±2.3 mo in subgroup B.RESULTS The“true defect”after resection was 13.3±1.7%in subgroup A and 31.0±3.0%in subgroup B relative to the contralateral limb.Upon completion of treatment,defects were filled by 75.4±10.6%and 34.6±4.2%,respectively.Total duration of external fixation was 397±9.2 and 270.1±16.3 d,including spacer retention time of 42.4±4.5 and 55.8±6.6 d,in subgroups A and B,respectively.Bone infection was not observed.Postoperative complications were several cases of pin-tract infection and regenerate deformity in both subgroups.Ischemic regeneration was observed in two cases of subgroup B.Complications were corrected during the course of treatment.Bone union was achieved in all patients of subgroup A and in seven patients of subgroup B.One non-united CPT case was further treated with the Ilizarov compression method only and achieved union.After a follow-up period of two to three years,refractures occurred in four cases of united CPT.CONCLUSION The combination of IMT and IBT provides good outcomes in post-traumatic tibial defects after previous treatment failure but external fixation is longer due to spacer retention.Refractures may occur in severe CPT. | Dmitry Y Borzunov Sergey N Kolchin Denis S Mokhovikov Tatiana A Malkova | 2022 | World Journal of Orthopedics2022，13，3： | 6 |
| 3 | Wnt signaling through T-cell factor phosphorylation显示文摘胚胎的发信号小径经常从缺省压抑导致一个开关到目标基因的 transcriptional 激活。Wnt 发信号的主要后果是 β 的稳定;把因素(TCF ) 与 T 房间联系并且从抑压者把他们“变换成” transcriptional 使活跃之物的 -catenin, 。为这个变换遗体负责的分子的机制糟糕理解。几研究由 phosphorylation 在 TCF 的规定上报导了,还它的生理的意义是不清楚的:在一些情况中,它看起来支持目标基因激活,在其它 Wnt 依赖的抄写被禁止。这评论由 Wnt 发信号在 TCF 功能的上下文依赖者 translational 以后规定的理解集中于最近的进步。 | Sergei Y Sokol | 2011 | Cell Research2011，21，7： | 5 |
| 4 | Thermodynamic evaluation and optimization of the MnO-Al2O3 and MnO-Al2 O3 SiO2 systems and applications to inclusion engineering显示文摘 | Jung I H Kang Y B Sergei A | 2004 | Metallurgy and Material Transaction B2004，35，4： | 1 |
| 5 | Management of displaced intraarticu lar calcaneal fractures by using external ring fixation,minimally invasive open reduction,and early weight bearing显示文摘 | George R Sergei Y | 2004 | J Foot Ankle Surg2004，43，1： | 1 |
| 6 | Preimplantation exposures of murine embryos to estradiol or methoxychlor change postnatal development显示文摘 | Elena A K Alevtina N G | 2004 | Reprod Toxicol2004，18，： | 1 |
| 7 | Performance of Li-ion cells with new electrolytes conceived for lowtemperature applications显示文摘 | SERGEY V S MIKHAIL Y K YEVGENIY N T | 2000 | Journal of Power Sources2000，87，： | 1 |
| 8 | Involvement of the Urokinase Kringle Domainin Lipopolysaccharide-Induced Acute Lung Injury显示文摘 | Xue-Qing W Khalil B Sergei Y | 2006 | Immunology2006，177，7： | 1 |
| 9 | Prevention of the selection of resistant staphylococcus aureus by moxifloxacin plus doxycycline in an in vitro dynamic model:andditive effect of the combination显示文摘 | ALEXANDER A F SERGEY N V IRENE Y L | 2004 | International Journal of Antimicrobial Agents2004，23，： | 1 |
| 10 | Plasma-induced Ignition and Plasma-assisted Combustion in High-speed Flow 显示文摘 | Sergey B Leonov Dmitry A Y | 2007 | Plasma Source Science and Technology2007，16，： | 1 |
| 11 | Antifouling diketopiperazines produced by a deep-sea bacterium, Streptomyces fungicidicus显示文摘 | Li XC Sergey D Xu Y | 2006 | Biofouling2006，22，3： | 1 |
| 12 | Management of displaced intraarticular calcaneal fractures by using external ringfixation, minimally invasive, open reduction, and early weightbearing显示文摘 | Leonard M George R Sergei Y | 2004 | J Foot Ankle Surg2004，43，1： | 1 |
| 13 | Management of displaced in- traartieular calcaneal fractures by using external ring fixation, minimally invasive open reduetiota, and early weight bearing显示文摘 | Leonard M George R Sergei Y | 2004 | J Foot Ankle Surg2004，43，1： | 1 |
| 14 | Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer显示文摘 | Wang I M Sergey Stepaniants S Boie Y | 2008 | A- merican Journal of Respiratory and Critical Care Medicine2008，177，： | 1 |
| 15 | Prevention of the selection of resistant Staphylococcus aureus by moxifloxacin plus doxycycline in an in vitro dynamic model : an additive effect of the combination 显示文摘 | Alexander A F Sergey N V Irene Y L | 2004 | International Journal of Antimicrobial Agents2004，23，5： | 1 |
| 16 | Trivial two-stage group testing for complexes using almost disjunct matrices 显示文摘 | Macula A J Vyacheslav V R Sergey Y | 2004 | Discrete Applied Mathematics2004，，137： | 1 |
| 17 | Multiphoton ionization of jet-cooled nickelocene with tunable nanosecond laser pulses显示文摘 | Sergey Y K Heinrich L S Edward W S | 2003 | Chemical physics2003，，293： | 1 |
| 18 | Management of displaced intraarticular calcaneal fractures by using external ring fixation, minimally invasive open reduction, and early weightbearing 显示文摘 | Leonard M George R Sergei Y | 2004 | J Foot Ankle Surg2004，43，1： | 1 |
| 19 | Acoustically controlled behavior of dust particles in high temperature gas atmosphere显示文摘 | Sergey V K Takkashi Y Tctsuya U D A ere | 2004 | ISU International2004，，44： | 1 |
| 20 | Viscoaoustic modeling and imaging using low-rank approximation显示文摘 | Sun J Z Zhu T Y Sergey F | 2014 | Ex- panded Abstracts of 84th Annual Internat SEG Mtg2014，，： | 1 |
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