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| 1 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 2 | Recovery of traceability links between software documentation and source code显示文摘 | Marcus A Malefic J I Sergeyev A | 2005 | International Journal of Software Engineering and Knowledge Engineering(IJSEKE)2005，15，5： | 1 |
| 3 | Firms R&D decisions under incomplete information显示文摘 | Grishagin V A Sergeyev Y D Silipo D B | 2001 | European Journal of Operational Research2001，29，1： | 1 |
| 4 | A model system to quantitate tumor bur-den in locoregional lymph nodes during cancer spread显示文摘 | Moore A Sergeyev N Bredow S | 1998 | Invasion Metastasis1998，18，4： | 1 |
| 5 | An efficient algorithm for the zero crossing detection in digitized measurement signal显示文摘 | A Molinaro Y D Sergeyev | 2001 | Measurement2001，30，3： | 1 |
| 6 | Monitoring the statistics of turbulence: Fried parameter estimation from the wavefront sensor measurements 显示文摘 | Sergeyev A V Roggemann M C | 2011 | Applied Optics2011，50，20： | 1 |
| 7 | Effects of Cultural Context on the Antecedents, Cot relates, and Consequences of Organizational Commitment: A Study of Russian Workers显示文摘 | Buchko A A Weinzimmer L G Sergeyev A V | 1998 | Journal of Business Research1998，，43： | 1 |
| 8 | Poly ( 3,4-ethylenedioxy- thiophene) : synthesis and properties 显示文摘 | Pyshkina O Kubarkov A Sergeyev V | 2010 | Scientific Proceedings of Riga Technical University Series 1 : Material Science and Applied Chemistry2010，21，51： | 1 |
| 9 | Scientific, engineering and metrological problems in producing pure 28Si and growing single crystals 显示文摘 | Tarbeyev Yu V Kaliteyevsky A K Sergeyev V I | 1994 | Metrologia1994，31，： | 1 |
| 10 | Recovery of tracea- bility links between software documentation and source code显示文摘 | MARCUS A MALETIC J I SERGEYEV A | 2005 | International Journal of Software Engineering and Knowledge Engi- neering2005，15，5： | 1 |
| 11 | Modeling polarization-de- pendent gain in fiber Raman amplifiers with randomly varying birefringenee 显示文摘 | Sergeyev S Popov S Friberg A T | 2006 | Optics Communications2006，262，： | 1 |
| 12 | Reactive oligomers based on the polycylotrimerization of acetylene compounds 显示文摘 | Sergeyev V A Shitikov V K Chemomordik Y A | 1975 | Applied Polymer Symposium1975，26，： | 1 |
| 13 | Firms R&D Decisions Under Incomplete Information 显示文摘 | GRISHAGIN V A SERGEYEV YD SILIPO D B | 2001 | European Journal of Operational Research2001，29，1： | 1 |
| 14 | Spun fiber Raman ampli- fiers with reduced polarization impairments 显示文摘 | Sergeyev S Popov S Friberg A T | 2008 | Optics Ex- press2008，16，14： | 1 |
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