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| 1 | 双调蛋白反义核酸表达对裸鼠乳腺癌血管生成的抑制作用显示文摘目的研究双调蛋白(AR)反义RNA表达对乳腺癌血管生成的抑制作用。方法乳腺癌NS2T2A1细胞经AR反义cDNA质粒转染后,经筛选获得表达AR反义RNA的AR-AS1及AR-AS3克隆,转染空载体获得NS2T2A1V对照细胞,接种裸鼠皮下形成肿瘤。研究条件培养液对人微血管内皮细胞(HMEC)增殖的影响,以ELISA法测定细胞血管内皮生长因子(VEGF)分泌量。以定量RT-PCR分析肿瘤组织的VEGF表达水平。以免疫组化法标记CD31研究肿瘤内血管数量。结果HMEC在AR-AS1和AR-AS3细胞条件培养液中的增殖比例明显降低。AR-AS1和AR-AS3细胞VEGF分泌量亦降低。AR-AS1和AR-AS3肿瘤的血管数量仅有对照组的50%左右,且VEGF表达显著降低。结论AR反义RNA表达可有效抑制乳腺癌的血管生成,应作为新治疗靶点进一步研究。 | 马林 SEROVA Maria PODGORNIAK Marie Pierre BERTHOIS Yolande MOURAH Samia CALVO Fabien | 2005 | 中华肿瘤杂志2005，27，9： | 3 |
| 2 | Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib显示文摘 | Maria Serova Armand Gramont Annemila? Tijeras-Raballand Célia Santos Maria Eugenia Riveiro Khemaies Slimane Sandrine Faivre Eric Raymond | 2013 | Cancer Chemotherapy and Pharmacology2013，，5： | 1 |
| 3 | Intranasal neuropeptide Y re- verses anxiety and depressive - like behavior impaired by single pro- longed stress FTSD model 显示文摘 | Serova LI Laukova M Alaluf LG | 2014 | Eur Neuropsychopharmacol2014，24，1： | 1 |
| 4 | Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells显示文摘 | Serova M Astorgues-Xerri L Bieche I | 2010 | Mol Cancer Ther2010，9，5： | 1 |
| 5 | Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells显示文摘 | Menashi S Serova M Ma L | | 0，，22： | 1 |
| 6 | Regulation of extracel-iular matrix metalloproteinase expression by amphiregulin intransformed human breast epithelial cells显示文摘 | Menashi S Serova M Ma L | 2003 | Cancer Res2003，63，22： | 1 |
| 7 | Increased susceptibility to transcriptional changes with novel stressor in adrenal medulla of rats exposed to prolonged cold stress显示文摘 | Liu X Kvetnansky R Serova L | 2005 | Brain Res Mol Brain Res2005，141，1： | 1 |
| 8 | Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in trans{ormed human breast epithe lialcells显示文摘 | Menashi S Serova M Ma L | 2003 | Cancer Res2003，63，22： | 1 |
| 9 | Adreno- eorticotropic hormone elevates gene expression for catecholamine biosynthesis in rat superior cervical ganglia and locus coeruleus by an adrenal independent mechanism显示文摘 | Serova L I Gueorguiev V Cheng S Y | 2008 | Neuroscience2008，153，： | 1 |
| 10 | Antibodies to Helicobacter pylori in gastric diseases显示文摘 | Lazebnik LB Tsaregorodtseva TM Serova TI | 2006 | Ter Arkh2006，78，2： | 1 |
| 11 | Preclinical and clinical development of novel agents that target the protein kinase C family显示文摘 | Serova M Ghoul A Benhadji KA | 2006 | Semin in Oncol2006，33，4： | 1 |
| 12 | Epithelial-to-mes- enchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells显示文摘 | Serova M Astorgues-Xerri L Bieche I | 2010 | Mol Cancer Ther2010，9，5： | 1 |
| 13 | Russia' s Transition to Major Player in World Agricultural Markets 显示文摘 | Liefert W M Liefert O Serova E | 2009 | Choices2009，24，2： | 1 |
| 14 | Epithelial-to-mesen-chy- mal transition and resistance to ingenol 3 - angelate,a novel protein kinase C modulator,in colon cancer ceils显示文摘 | Ghoul A Serova Astorgues-Xerri L | 2009 | Cancer Res2009，69，10： | 1 |
| 15 | Cytokines in primary biliary cirrhosis(diagnostic and prognostic value)显示文摘 | Golovanova E V II'chenko L Iu Tsaregoro dtseva T M Serova T I Gudkova R B | 2004 | Ter Arkh2004，76，： | 1 |
| 16 | Regulation of extracel-lular matrix metallop roteinase expression by amphiregulin intransformed human breast epithelial cells显示文摘 | Menashi S Serova M Ma L | 2003 | Cancer Res2003，63，22： | 1 |
| 17 | A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families显示文摘 | Montagna M Torchand D | 1996 | Am J Hum Genet1996，58，： | 1 |
| 18 | Effects of protein kinase C modulation by PEP005,a novel ingenol angelate,on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells显示文摘 | Serova M Ghoul A Benhadji K A | 2008 | Mol Cancer Ther2008，7，4： | 1 |
| 19 | Epithelial -to - mesenchymal transition and resistance to ingenol 3 - angelate, a novel protein kinase C modulator, in colon cancer cells显示文摘 | Ghoul A Serova M Astorgues Xerri L | 2009 | Can- cer Res2009，69，10： | 1 |
| 20 | mTORCl Inhibitors:is temsirolimus in renal cancer telling us how they really work?显示文摘 | Toumeau CL Faivre S Serova M | 2008 | Br J Cancery2008，99，8： | 1 |
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