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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | The Hallmarks of Aging显示文摘 | Carlos López-Otín Maria A. Blasco Linda Partridge Manuel Serrano Guido Kroemer | 2013 | Cell2013，，6： | 5 |
| 3 | Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells显示文摘AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating levels.METHODS Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake assay.RESULTS In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance. | Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar | 2017 | World Journal of Diabetes2017，8，4： | 2 |
| 4 | Human CRP gene polymorphism influences CRP levels:implications for the prediction and pathogenesis of coronary heart disease显示文摘 | Brull DJ Serrano N Zito F | 2003 | Arterioscler Thromb Vasc Biol2003，23，11： | 1 |
| 5 | Human CRP gene poly- morphism influences CRP levels:implications for the pre- diction and pathogenesis of coronary heart disease显示文摘 | Brull DJ Serrano N Zito F | 2003 | Ar- terioscler Thromb Vasc Biol2003，23，11： | 1 |
| 6 | Direct prediction of bioethanol yield in sugar beet pulp using Near Infrared Spectroscopy显示文摘 | C. Maga?a N. Nú?ez-Sánchez V.M. Fernández-Cabanás P. García A. Serrano D. Pérez-Marín J.M. Pemán E. Alcalde | 2011 | Bioresource Technology2011，，20： | 1 |
| 7 | Effect of ethylene concentration on quality parameters of fresh tomatoes stored using a carbon-heat hybrid ethylene scrubber显示文摘 | Domingo Martínez-Romero Fabián Guillén Salvador Castillo Pedro Javier Zapata Daniel Valero María Serrano | 2008 | Postharvest Biology and Technology2008，，2： | 1 |
| 8 | Human CRP gene polymorphism influences CRP levels:implications for the prediction and pathogenesis of coronary heart disease显示文摘 | Brull DJ Serrano N Zito F | 2003 | Arterioscler Thromb Vase Biol2003，23，11： | 1 |
| 9 | The addition of essential oils to MAP as a tool to maintain the overall quality of fruits显示文摘 | SERRANO M MART NEZ-ROMERO D GUILL N F | 2008 | Trends in Food Science & Technology2008，19，9： | 1 |
| 10 | Prolonged intubation rates 'after coronary artery bypass surgery and ICU risk stratification score 显示文摘 | Serrano N Garcia C Villegas J | 2005 | Chest2005，128，2： | 1 |
| 11 | Combustion simulation of turbocharger HSDI Diesel engines during transient operation using neural networks显示文摘 | J. Galindo J.M. Luján J.R. Serrano L. Hernández | 2004 | Applied Thermal Engineering2004，，5： | 1 |
| 12 | Human CRP gene polymorphism influences CRP Ievels: implications for the prediction and pathogenesis of coronary heart disease arterioscler 显示文摘 | BRULL DJ SERRANO N ZITO F | 2003 | Thromb Vasc Biol2003，23，： | 1 |
| 13 | Isolation of Campylobacter pylori from the gastric mucosa by gram stain and culture显示文摘 | URRESTARAZU DE GARCIA M I SERRANO DE CARRERA N PINERO R | 1988 | G E N1988，42，： | 1 |
| 14 | Model of the expansion process for R245fa in an Organic Rankine Cycle (ORC)显示文摘 | J.M. Luján J.R. Serrano V. Dolz J. Sánchez | 2012 | Applied Thermal Engineering2012，，： | 1 |
| 15 | Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition显示文摘 | Milara J Navarro R Juan G PeiróT Serrano A Ramón M | 2012 | Thorax2012，67，2： | 1 |
| 16 | Solving the collision detection problem 显示文摘 | GARCIA-ALONSO A SERRANO N FLAUER J | 1994 | IEEE Computer Graphics and Applications1994，14，3： | 1 |
| 17 | Afforestation improves soil fertility in south-eastern Spain 显示文摘 | Ferna′ndez-Ondon?o F Rojo Serrano L Jime′nez MN Navarro FB D?′ez M Mart?′n F Ferna′ndez J Mart?′nez FG Roca A Aguilar J | 2010 | Eur J For Res2010，129，： | 1 |
| 18 | Cisplatin and gemcitabine administered every two weeks in patients with locally advanced or metastatic urothelial carcinoma and impaired renal function显示文摘 | Rafael Morales-Barrera Joaquim Bellmunt Cristina Suárez Claudia Valverde Marta Guix Cesar Serrano Manuel Gallén Joan Carles | 2012 | European Journal of Cancer2012，，12： | 1 |
| 19 | Cisplatin and gemcitabine administered every two weeks in patients with locally advanced or metastatic urothelial carcinoma and impaired renal function显示文摘 | Rafael Morales-Barrera Joaquim Bellmunt Cristina Suárez Claudia Valverde Marta Guix Cesar Serrano Manuel Gallén Joan Carles | 2012 | European Journal of Cancer2012，，12： | 1 |
| 20 | Cereal protein analysis via Dumas method: Standardization of a micro- method using the EuroVector Elemental Analyser显示文摘 | S Serrano F Rinc 6 n J Garc f a-Olmo | 2013 | Journal of Cereal Science2013，58，2013： | 1 |
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