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| 1 | Role of receptor tyrosine kinases in gastric cancer: New targets for a selective therapy显示文摘受体酷氨酸家族 ases (RTK ) 象表皮的生长因素受体家庭那样包括增长和变形传播参予肿瘤形成的几步。几已知的 RTK 起来在是主要的胃的癌症调整了定制的治疗的目标。仅仅初步的数据然而,在使用上存在当前临床上可得到的药象在胃的癌症的背景的 trastuzumab, cetuximab, bevacizumab, gefitinib, erlotinib,和 imatinib 那样。现出症状之前的潜的数据建议他们的使用的一个潜在的好处,特别在有“常规”的抑制细胞的联合治疗。这评论象新途径和药一样在癌症治疗关于他们的使用总结当前的知识优化治疗成功。 | JC Becker C Müller-Tidow H Serve W Domschke T Pohle | 2006 | World Journal of Gastroenterology2006，12，21： | 19 |
| 2 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis显示文摘AIM:To evaluate the impact of metadoxine(MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).METHODS:This study was an open-label clinical trial,performed at the'Hospital General de México,Dr.Eduardo Liceaga'.We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(PDN)40 mg/d,35patients received PDN+MTD 500 mg three times daily,33 patients received pentoxifylline(PTX)400 mg three times daily,and 32 patients received PTX+MTD 500 mg three times daily.The duration of the treatment for all of the groups was 30 d.RESULTS:In the groups treated with the MTD,thesurvival rate was higher at 3 mo(PTX+MTD 59.4%vs PTX 33.3%,P=0.04;PDN+MTD 68.6%vs PDN20%,P=0.0001)and at 6 mo(PTX+MTD 50%vs PTX18.2%,P=0.01;PDN+MTD 48.6%vs PDN 20%,P=0.003)than in the groups not treated with MTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 mo.The patients receiving MTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,P=0.02).CONCLUSION:MTD improves the 3-and 6-mo survival rates in patients with severe AH.Alcohol abstinence is a key factor for survival in these patients.The patients who received the combination therapy with MTD were more likely to maintain abstinence than those who received monotherapy with either PDN or PTX. | Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-Zúniga Javier Cruz-Herrera Eduardo Pérez-Torres Juan M Abdo-Francis Francisco Salas-Gordillo JoséL Pérez-Hernández | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 3 | Case of Aeromonas veronii( DNA Group 10 ) bacteremia 显示文摘 | ABBOTT S L SERVE H JANDA J M | 1994 | J Clin Microbiol1994，32，12： | 1 |
| 4 | Purification and characterization of an extremely thermostable beta-glucosidase from the hyperther mophilic archae on Pyrococcus furiosus显示文摘 | Serve W M Kengen Evert J Luesink | 1993 | Eur J Biochem1993，213，： | 1 |
| 5 | Review of the aquatic toxicity, estrogenic responses and bioaccumulation of alkylphenols and polyethox ylates显示文摘 | Serves M R | 1999 | Water Quality Reseach Journal of Canada1999，34，1： | 1 |
| 6 | Expression of the growth hormone gene in the ovine placenta:detection and cellular localization of the protein 显示文摘 | LACROIX M C DEVINOY E SERVELY J L | 1996 | Endocrinology1996，137，： | 1 |
| 7 | Case of Aeromonas veronii (DNA Group 10) Bacteremia显示文摘 | Abbott S L Serve H Janda J M | 1994 | Journal of Clinical Microbiology1994，32，12： | 1 |
| 8 | Cytokinins modulate the expression of genes encoding the protein of the light-harvesting chlorophylla6b complex 显示文摘 | Teyssendier dela serve B Axelos M Peaud-Lenoel C | 1985 | Plant Mol Biol1985，，5： | 1 |
| 9 | RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation显示文摘 | Schw?ble J Choudhary C Thiede C Tickenbrock L Sargin B Steur C Rehage M Rudat A Brandts C Berdel WE Müller-Tidow C Serve H | | 0，，： | 1 |
| 10 | Distribution of estrogens, 17B-estradiol and estrone, in Canadian municipal wastewater treatment plants 显示文摘 | Serves M R Bennie D T Burnison B K | 2005 | Science of the Total Environment2005，336，13： | 1 |
| 11 | In vivo and in vitro antiarrhythmic effects of SSR149744C in animal models of atrial fibrillation and ventricular arrhythmias 显示文摘 | Gautier P Serve M Cosnier-Pucheu S | 2005 | J Cardiovasc Pharmacol2005，45，2： | 1 |
| 12 | Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols显示文摘 | Styblo M Serves SV Cullen WR | 1997 | Chem ResToxicol1997，10，： | 1 |
| 13 | High-quality and economically viable coating by means of tandem gas-shielded metal-arc welding显示文摘 | Appel D L Serve M Baum L | 2002 | Welding and Cutting2002，54，5： | 1 |
| 14 | Knetic basis for the substrate specificity during hydrolysis of phospholipids by secreted phospholipase A2显示文摘 | Joseph Rogers Bao-zhu Yu Spyros V serves Gerasimos M Tsivgoulis Demetrious N Sotiropoulos Panayiotis V loannou Mahendra Kumar Jain | 1996 | Biochemistry1996，，35： | 1 |
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