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| 1 | Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances显示文摘A simple analytical high-performance liquid chromatography(HPLC) method was applied for the enantiomeric excess determination of esomeprazole((S)-OME), the enantiopure active ingredient contained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separation was accomplished on the immobilized-type Chiralpak ID-3 chiral stationary phase(CSP)under reversed-phase conditions. The results were evaluated and compared with those obtained by the of fi cial enantioselective method of European Pharmacopoeia used as the reference for checking the enantiomeric excess of(S)-OME. It has been established that the use of the Chiralpak ID-3 CSP allows the determination of the enantiomeric purity of(S)-OME without any interference coming from its chiral and achiral related substances. The analytical procedure of the drug regulatory agencies based on the AGP CSP suffered instead from poor speci fi city due to overlap of the peaks pertinent to the achiral impurity A and the chiral impurity(R)-OME(impurity F). | Bruno Gallinella Rosella Ferretti Leo Zanitti Isabella Sestili Antonina Mosca Roberto Cirilli | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 2 | ddRAD sequencing-based genotyping for population structure analysis in cultivated tomato provides new insights into the genomic diversity of Mediterranean‘da serbo’type long shelf-life germplasm显示文摘Double digest restriction-site associated sequencing(ddRAD-seq)is a flexible and cost-effective strategy for providing in-depth insights into the genetic architecture of germplasm collections.Using this methodology,we investigated the genomic diversity of a panel of 288 diverse tomato(Solanum lycopersicum L.)accessions enriched in‘da serbo’(called‘de penjar’in Spain)long shelf life(LSL)materials(152 accessions)mostly originating from Italy and Spain.The rest of the materials originate from different countries and include landraces for fresh consumption,elite cultivars,heirlooms,and breeding lines.Apart from their LSL trait,‘da serbo’landraces are of remarkable interest for their resilience.We identified 32,799 high-quality SNPs,which were used for model ancestry population structure and non-parametric hierarchical clustering.Six genetic subgroups were revealed,clearly separating most‘da serbo’landraces,but also the Spanish germplasm,suggesting a subdivision of the population based on type and geographical provenance.Linkage disequilibrium(LD)in the collection decayed very rapidly within<5 kb.We then investigated SNPs showing contrasted minor frequency allele(MAF)in‘da serbo’materials,resulting in the identification of high frequencies in this germplasm of several mutations in genes related to stress tolerance and fruit maturation such as CTR1 and JAR1.Finally,a mini-core collection of 58 accessions encompassing most of the diversity was selected for further exploitation of key traits.Our findings suggest the presence of a genetic footprint of the‘da serbo’germplasm selected in the Mediterranean basin.Moreover,we provide novel insights on LSL‘da serbo’germplasm as a promising source of alleles for tolerance to stresses. | Salvatore Esposito Teodoro Cardi Gabriele Campanelli Sara Sestili María JoséDíez Salvador Soler Jaime Prohens Pasquale Tripodi | 2020 | Horticulture Research2020，7，1： | 2 |
| 3 | Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian ceils via direct antioxidant activity显示文摘 | Sestili P Martinelli C Bravi G | 2006 | Free Radical Biology and Medicine2006，40，： | 1 |
| 4 | The antioxidant butylated hydroxytoluene induces apoptosis in human U937 cells: the role of hydrogen peroxide and altered redox state显示文摘 | Palomba L Sestili P Cantoni O | 1999 | Free Radic Res1999，31，2： | 1 |
| 5 | Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA显示文摘 | Guidi C Potenza L Sestili P | 2008 | Biochimica et Biophysica Acta(BBA)-General Subjects2008，1780，1： | 1 |
| 6 | Characterization Of KNOX genes in Medicago truncatula显示文摘 | Di Giacomo E Sestili F Iannelli M A | 2008 | Plant Molecular Biology2008，67，12： | 1 |
| 7 | A novel wheat variety with elevated content of amy- lose increases resistant starch formation and may bene- ficially influence glycaemia in healthy subjects 显示文摘 | HALLSTROM E SESTILI F LAFIANDRA D | 2011 | Food & Nutrition Research2011，55，： | 1 |
| 8 | Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via directantioxidant activity显示文摘 | Sestili P Martinelli C Bravi G | 2006 | Free Radical Biology and Medicine2006，40，5： | 1 |
| 9 | Calcium chelator Quin 2 provents hydrogen-peroxide-induced DNA breakage and cytotoxicity显示文摘 | CANTONI O SESTILI P CATTABENI F | 1989 | Eur J Biochem1989，182，2： | 1 |
| 10 | Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide:free radical scavenging versus iron chelating mechanism显示文摘 | Sestili P Guidarelli A Dacha M | 1998 | Free Radical Biology and Medicine1998，25，2： | 1 |
| 11 | Pomegranate peel and fruit extracts:A review of potential anti-inflammatory and anti- infective effects 显示文摘 | Ismail T Sestili P Akhtar S | 2012 | J Ethnopharmacol2012，143，2： | 1 |
| 12 | Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression B-cell and T-cell homeostatic proliferation and specifictumor in filtration显示文摘 | Bracci L Moschella F Sestili P | 2007 | Clin Cancer Res2007，13，2： | 1 |
| 13 | A novel wheat variety with elevated content of amylose increases resistant starch formation and may beneficially influence glycaemia in healthy subjects显示文摘 | Hallstri~m E Sestili F Lafiandra D Bj~rck I Ostman E | 2011 | Food & Nutrition Research2011，55，1： | 1 |
| 14 | Increasing the amylose content of durum wheat through silencing of the SBEIIa genes显示文摘 | Sestili F Janni M Doherty A E | | 0，，01： | 1 |
| 15 | Increasing the amylose content of durum wheat through silencing of the SBEIIa genes 显示文摘 | Sestili F Janni M Doherty A | 2010 | BMC Plant Biology2010，10，： | 1 |
| 16 | Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA 显示文摘 | Guidi C Potenza L Sestili P | 2008 | Biochimica etBiophysica Acta( BBA)2008，1780，： | 1 |
| 17 | Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butyl hydroperoxide:free radical scavenging versus iron chelating mechanism显示文摘 | Sestili P Guidarelli A Dacha M | 1998 | Free Radio Biol Med1998，25，2： | 1 |
| 18 | Plasma levels of soluble CD36,platelet activation, inflammation, and oxidative stress are increased in type 2 diabetic patients 显示文摘 | Liani R Halvorsen B Sestili S | 2012 | Free Radic Biol Med2012，52，8： | 1 |
| 19 | Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression,B-cell and T-cell homeostatic proliferation,and specific tumor infiltration显示文摘 | Bracci L Moschella F Sestili P | 2007 | Clin Cancer Res2007，13，： | 1 |
| 20 | Quercetin prevents DNA single strand break age and eytotoxicity caused by tert - butylhy - droperoxide free radieal scavenging versus iron chelating meehanism显示文摘 | Sestili P Guidarelli A Daeha M | 1998 | Free Radie Biol Med1998，25，2： | 1 |
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