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| 1 | Prevalence of variations and anomalies of the upper labial frenum显示文摘 | Sewerin I | 1971 | Acta Odontol Scand1971，29，4： | 1 |
| 2 | A clinical and epidemiologie study morsicatio buccarum-labiorum显示文摘 | Sewerin I | 1971 | Scand J Dent Res1971，79，2： | 1 |
| 3 | Comparison of quantitative and semiquantitative dynamic contrast-enhanced MRI with respect to their correlation to delayed gadolinium-enhanced MRI of the cartilage in patients with early rheumatoid arthritis显示文摘 | Muller-Lutz A Schleich C Sewerin P | 2015 | J Comput Assist Tomogr2015，39，1： | 1 |
| 4 | Radiographic assessment of simulated root resorption cavities 显示文摘 | Andreasen FM Sewerin I Mandel U | 1987 | Endod Dent Traumatol1987，3，1： | 1 |
| 5 | Radiographic assessment of simulated root resorption cavities显示文摘 | Andreasen FM Sewerin I Mandel U | | 0，，01： | 1 |
| 6 | Radiographic assessment of simulated root resorption cavities显示文摘 | Andreasen FM Sewerin I Mandel U | 1987 | Endod Dent Traumatol1987，3，1： | 1 |
| 7 | Radiographic assess- ment of simulated root resorption cavities 显示文摘 | Andreasen FM Sewerin I Mandel U | 1987 | Endod Dent Trau- matol1987，3，1： | 1 |
| 8 | Utility of combined high-resolution bone SPECT and MRI for the identification of rheumatoid arthritis patients with high-risk for erosive progression显示文摘 | Buchbender C Sewerin P Mattes-Gyürgy K et at | | 0，，： | 1 |
| 9 | Utility of combined high-resolution bone SPECT and MRI for the identification of rheumatoid arthritis patients with high-risk for erosive progression 显示文摘 | Buchbender C Sewerin P Mattes-Gyorgy K | 2013 | European Journal of Radiology2013，82，2： | 1 |
| 10 | Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly显示文摘Formation of claudin-10 based tight junctions(TJs)is paramount to paracellular Na+transport in multiple epithelia.Sequence variants in CLDN10 have been linked to HELIX syndrome,a salt-losing tubulopathy with altered handling of divalent cations accompanied by dysfunctional salivary,sweat,and lacrimal glands.Here,we investigate molecular basis and phenotypic consequences of a newly identified homozygous CLDN10 variant that translates into a single amino acid substitution within the fourth transmembrane helix of claudin-10.In addition to hypohidrosis(H),electrolyte(E)imbalance with impaired urine concentrating ability,and hypolacrimia(L),phenotypic findings include altered salivary electrolyte composition and amelogenesis imperfecta but neither ichthyosis(I)nor xerostomia(X).Employing cellular TJ reconstitution assays,we demonstrate perturbation of cis-and trans-interactions between mutant claudin-10 proteins.Ultrastructures of reconstituted TJ strands show disturbed continuity and reduced abundance in the mutant case.Throughout,both major isoforms,claudin-10a and claudin-10b,are differentially affected with claudin-10b showing more severe molecular alterations.However,expression of the mutant in renal epithelial cells with endogenous TJs results in wild-type-like ion selectivity and conductivity,indicating that aberrant claudin-10 is generally capable of forming functional paracellular channels.Thus,mutant proteins prove pathogenic by compromising claudin-10 TJ strand assembly.Additional ex vivo investigations indicate their insertion into TJs to occur in a tissue-specific manner. | Sebastian Sewerin Jorg Piontek Ria Schonauer Sonja Grunewald Angelika Rauch Steffen Neuber Carsten Bergmann Dorothee Gunzel Jan Halbritte | 2022 | Genes & Diseases2022，9，5： | 0 |
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