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| 1 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 2 | Sj?gren-Larsson syndrome in clinical practice显示文摘 | Fuijkschot J Theelen T Seyger MM | 2012 | J Inherit Metab Dis2012，35，6： | 1 |
| 3 | Selective persistence of dermal CD8 T cells in lesional plaque psoriasis after clobetasol- 17 propionate treatment 显示文摘 | Bovenschen H J Vissers WH Seyger MM | 2005 | Acta Derm Venereol2005，85，2： | 1 |
| 4 | Localized and systemic scleroderma show different histological responses to methotrexate therapy显示文摘 | van den Hoogen FH van Vlijmen-Willems IM | 2001 | J Pathol2001，193，4： | 1 |
| 5 | 比较斑块型银屑病与异位性皮炎和扁平苔藓皮损的T细胞亚群、表皮增生和分化 | Bovenschen H.J Seyger M.M.B Van De Kerkhof P.C.M 李晓莉 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，10： | 1 |
| 6 | CD26/dipeptidyl-peptidase IV in psoriatic skin:up-regulation and topographical changes显示文摘 | Van Lingen RG Van De Kerkhof PCM Seyger MMB | | 0，，06： | 1 |
| 7 | The fu- ture of swelling elastomers: An elastomer manu- facturer's view of swelling elastomer develop- ments and market trends显示文摘 | SEYGER R RESINK S HARMS H | 2013 | RUMA Products BV2013，10，1： | 1 |
| 8 | Loco-dose methotnexate in the treatment of widespread morphea 显示文摘 | Seyger MMB van der Hoogen | 1988 | JAm Aead Dermato1988，39，： | 1 |
| 9 | Selective persistence of dermal CD8 + T cells in lesional plaque psoriasis after clobetasol-17 propionate treatment显示文摘 | Bovenschen HJ Vissers WH Seyger MM | 2005 | Acta Derm Venereol2005，85，2： | 1 |
| 10 | 脉冲染料激光治疗局限性顽固性斑块状银屑病的有效性:一项比较研究显示文摘Background: Localized chronic plaque psoriasis, resistant to local therapy, may be very hard to treat. The treatment of these lesions with a pulsed dye laser (PDL) has been described before, but a comparative study between the PDL and a potent topical treatment has never been performed. Objectives: To compare the efficacy of the PDL in the treatment of localized, recalcitrant plaque psoriasis with a potent topical therapy, using calcipotriol/betamethasone dipropionate (Dovobet ) as an active comparator. Methods: Eight patients with psoriasis were treated with both PDL(585 nm) and calcipotriol/ betamethasone dipropionate in an open, intrapatient, left-right comparison. A plaque severity score (sum score) and photographs were used to document the course of therapy. Patients reported pain on a visual analogue scale. Results: Both treatments were well tolerated, although one patient left the study due to post-PDL treatment pain. A significant difference in the sum score 12 weeks after treatment was seen in favour of the PDL (62% vs. 19% reduction; P < 0.05). Scores for erythema declined significantly at week 12 in both the PDL and the calcipotriol/betamethasone dipropionate group (P < 0.001). Induration and desquamation scores were significantly reduced at week 12 in the PDL group, without a statistically significant reduction in calcipotriol/betamethasone- treated lesions. The pain scores declined with progressive PDL treatments, although not statistically significantly. Conclusions: PDL treatment might be considered for the treatment of localized, recalcitrant plaque psoriasis, when other topical therapies have failed. | Erceg A. Bovenschen H. J. Van De Kerkhof P.C.M. Seyger M. M. B. 李政霄(译) | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，9： | 0 |
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