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| 1 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | Results of Total Knee Replacement for Isolated Patellofemoral Arthritis: When Not to Perform a Patellofemoral Arthroplasty显示文摘 | Ronald E. Delanois Mike S. McGrath Slif D. Ulrich David R. Marker Thorsten M. Seyler Peter M. Bonutti Michael A. Mont | 2008 | Orthopedic Clinics of North America2008，，3： | 2 |
| 3 | Osteonecrosis of the knee after laser or radiofrequency-assisted arthroscopy: treatment with minimally invasive knee arthroplasty 显示文摘 | BONUTTI PM SEYLER TM DELANOIS RE | 2006 | J Bone Joint Surg Am2006，88，3： | 1 |
| 4 | Total hip arthroplasties :what are the reasons for revision 显示文摘 | Ulneh SD Seyler TM Bennett D | 2008 | Int Orthop2008，32，5： | 1 |
| 5 | Advances in hip arthroplasty in the treatment of osteonecrosis显示文摘 | Seyler TM Cui Q Mihalko WM | 2007 | Instr Course Lect2007，56，： | 1 |
| 6 | Medium-term sur- vival, morbidity and immunovirological evolution in HIV-infected adults receiving antiretroviral therapy, Abidjan, Cote divoire 显示文摘 | Seyler C Anglaret X Dakoury-Dogbo N | 2003 | Antivir Ther2003，8，5： | 1 |
| 7 | Knee Arthroplasties Have Similar Results in High- and Low-activity Patients显示文摘 | Mont MA Marker DR Seyler TM | 2007 | Clin Orthop2007，460，： | 1 |
| 8 | Synthesis and in vitro evaluation of 68Ga-DOTA-4-FBn-TN14003, a novel tracer for the imaging of CXCR4 expression显示文摘 | Hennrich U Seyler L Sch-fer M | 2012 | Bioorg Med Chem2012，20，4： | 1 |
| 9 | Distribution andbehaviour of arsenic in Yellow River estuary and Bohai Sea 显示文摘 | Huang W W Martin J M Seyler P | 1988 | Marine Chemistry1988，25，1： | 1 |
| 10 | Rest oring range of motion via stress relaxation and static progressive stretch in posttraumatic elbow contractures显示文摘 | Ulrich SD Bonutti PM Seyler TM | | 0，，02： | 1 |
| 11 | Diffusion-weighted ima-ging in rectal carcinoma patients without and after chemoradio-therapy: a comparative study with histology显示文摘 | Bauerle T Seyler L Munter M | 2013 | Eur J Radiol2013，82，3： | 1 |
| 12 | Botulinum toxin type A injections for the management of flexion contractures following total knee arthroplasty显示文摘 | Seyler TM Jinnah RH Korean LA | 2008 | J Surg Orthop Adv2008，17，4： | 1 |
| 13 | Isoformspecific silencing of the Livin gene by RNA interferencedefines Livin beta as key mediator of apoptosis inhibition in Helacells显示文摘 | CRNKOVIC MERTENS I SEMZOW J HOPPE SEYLER F etal | 2006 | J Mol Med2006，84，3： | 1 |
| 14 | Results of early stage osteonecrosis of the femoral head 显示文摘 | Marker DR Seyler TM | 2008 | J Bone Joint SurgAm2008，90，： | 1 |
| 15 | Do modern techniques improve core decompression outcomes for hip osteonecrosis显示文摘 | Marker DR Seyler TM Ulrich SD | 2008 | Clin Orthop Relat Res2008，5，： | 1 |
| 16 | Functional problems and treatment solutions after total hip arthmplasty 显示文摘 | Bhave A Marker DR Seyler TM | 2007 | J Arthroplasty2007，22，2： | 1 |
| 17 | Restoring range of motion via stress relaxation and static progressive stretch in posttraumatic elbow contractures显示文摘 | Ulrich SD Bonutti PM Seyler TM | 2010 | J Shoulder Elbow Surg2010，19，2： | 1 |
| 18 | Advances in hip arthroplasty in the treatment of osteonecrosis 显示文摘 | Seyler TM Cui Q Mihalko WM | 2007 | Instr Course Lect2007，56，： | 1 |
| 19 | New treatment approaches for osteo- necrosis of the femoral head : an overview 显示文摘 | Mont MA Jones LC Seyler TM | 2007 | Instructional course lectures2007，56，： | 1 |
| 20 | Ex- portation of organic carbon from the Amazon River and its main tributaries 显示文摘 | MOREIRA T P SEYLER P GUYOT J L | 2003 | Hydrol Process2003，17，7： | 1 |
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