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| 1 | Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study显示文摘AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, respectively.CONCLUSION Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies. | Zeynep Gural Sezer Saglam Serap Yucel Esra Kaytan-Saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov Semen Onder Ahmet Kizir Ethem N Oral | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 3 |
| 2 | Attributes of cancer patients admitted to the emergency department in one year显示文摘BACKGROUND: Cancer patients frequently visit the emergency department(ED) with various symptoms of cancer. The purpose of this study was to determine the clinical characteristics and 1-year survival rate of cancer patients in the ED of a university hospital.METHODS: We conducted a retrospective review of 408 cancer patients who visited the ED between January 2011 and December 2011. Patient information on demographics, chief complaints, fi ndings, and survival was gathered from the hospital registry and corresponding health administration.RESULTS: The study included 240(58.8%) males and 168(41.2%) females with a median age of 57.9 years(range 19–87). Regarding cancer staging, 266 patients(65.3%) had metastatic disease and 142(34.7%) had local and loco-regional disease. The hospitalization rate was 59.6%. The most common symptoms were shortness of breath(23.2%), pain(17.8%), fever(14.2%), and nausea/vomiting(14.4%). The most common cancer sites were the lung(32.5%), gastrointestinal system(25.4%), and breast(9.3%). The initial evaluation determined progressive disease(42.4%), chemotherapy effects(20.7%), infections(17.2%), radiotherapy effects(4.7%), extravasation(1.8%), anemia(1.4%), and unknown(11.3%). During follow up, 191(46.8%) patients died after admission to the ED. The 1-year overall survival of all patients was 7.3 months.CONCLUSIONS: Symptom management in cancer patients is a complex multifaceted concern for the emergency physician. Because of the increasing prevalence of cancer patients, emergency physicians should develop consensus algorithms in collaboration with the relevant disciplines to manage the commonly encountered problems. | Muallaoglu Sadik Karagün Ozlem Mertsoylu Huseyin Besen AliAyberk Sezer Ahmet Ozyilkan Ozgur | 2014 | World Journal of Emergency Medicine2014，5，2： | 3 |
| 3 | Clinical results of the liquidbased cervical cytology tool,Liqui-PREP,in comparison with conventional smears for detection of squamous cell abnormalities显示文摘 | Canda MT Demir N Sezer O | 2009 | Asian Pac J Cancer Prev2009，10，3： | 1 |
| 4 | Clinical resu]Is of the liquid based cervical cytology tool, Liqui-PREP, in comparison with conventional smears for detection of squamous cell abnormalities 显示文摘 | Canda MT Demir N Sezer O | 2009 | Asian Pae J Cancer Prev2009，10，3： | 1 |
| 5 | Protective effect of everolimus on renal ischemia reperfusion injury in rats显示文摘 | Sagiroglu T Sezer A Torun N | 2014 | Saudi J Kidney Dis Transpl2014，25，2： | 1 |
| 6 | Diagnostic value of ultrasonography in appendicitis显示文摘 | Sezer TO Gulece B Zalluhoglu N | 2012 | Adv Clin Exp Med2012，21，5： | 1 |
| 7 | Solution of Dirichlet problem for a triangle region in terms of elliptic functions显示文摘 | Kurt N Sezer M | 2006 | Applied Mathematics and Computation2006，，182： | 1 |
| 8 | Mirror therapy improves hand function in subacute stroke: a randomized controlled trial显示文摘 | Yavuzer G Selles R Sezer N | 2008 | Arch Phys Med Rehabil2008，89，3： | 1 |
| 9 | The Effects of Estrogen and Raloxifene Treatment on Antioxidant Enzymes in Brain and Liver of Ovarectomized Female Rats显示文摘 | Mert ?zg?nül Ay?in ?ge Ebru Demirel Sezer Firat Bayraktar Eser Yildirim S?zmen | 2003 | Endocrine Research2003，，2： | 1 |
| 10 | Clinical results of the liquid- based cervical cytology tool, Liqui -PREP, in comparison with conventional smears for detection of squamous cell abnormalities 显示文摘 | Canda MT Demir N Sezer O | 2009 | Asian Pac J Cancer Prey2009，10，5： | 1 |
| 11 | The isolation of a virus as the cause of Behcet's diseases显示文摘 | SEZER F N | 1953 | Am J Ophthalmol1953，36，3： | 1 |
| 12 | Impact of first trimester and postpartum period thyroid autoantibodies on abortus incidence in Turkish pregnant women显示文摘 | Sezer K Kamel N Unlu C | 2009 | Gynecol Endocrinol2009，25，6： | 1 |
| 13 | The effect of pulsed electromagnetic fields in the treatment of cervical osteoarthritis:a randomized,double-blind,sham-controlled trial显示文摘 | Sutbeyaz ST Sezer N Koseoglu BF | | 0，，4： | 1 |
| 14 | Successful treatment of advanced endometriosis with extremely high CA125 and moderately elevated CA15 -3 levels 显示文摘 | Canda M T Demir N Sezer O | 2008 | Clin Exp Obstet Gynecol2008，35，3： | 1 |
| 15 | Effect of supportive extracorporeal treatment in liver transplantation recipients and advanced liver failure patients显示文摘 | Ozdemir F N Tutal E Sezer S | 2006 | Hemodial Int2006，10，： | 1 |
| 16 | Mirror therapy improves hand function in subacute stroke: a randomized controlled trail显示文摘 | Yavuzer G Selles R Sezer N | 2008 | Arch Phys Med Rehabil2008，89，： | 1 |
| 17 | Clinical results of the liquidbased cervical cytology tool, Liqui - PREP, in comparison with conventional smears for detection of squamous cell abnorm all- ties显示文摘 | CANDA M T DEMIR N SEZER O | 2009 | Asian Pac J Cancer Prey2009，10，3： | 1 |
| 18 | Mirror therapy improves hand function in subaeute stroke: a randomized controlled trial 显示文摘 | Yavuzer G Selles R Sezer N | 2008 | Arch Phys Med Rehabil2008，89，3： | 1 |
| 19 | Mirror therapy improves hand function in subacute stroke: a randomized controlled trial 显示文摘 | Yavuzer G SeUes R Sezer N etal | 2008 | Arch PhysMedRehabil2008，89，3： | 1 |
| 20 | Diagnostic value of ultrasonography in appendicitis 显示文摘 | Sezer TO Gulece B Zalluhoglu N | 2012 | Adv Clin Exp Med2012，21，5： | 1 |
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