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| 1 | Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis显示文摘AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed. | Jonathan G Stine Puja M Shah Scott L Cornella Sean R Rudnick Marwan S Ghabril George J Stukenborg Patrick G Northup | 2015 | World Journal of Hepatology2015，7，27： | 42 |
| 2 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 3 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 4 | Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications显示文摘The emergence of orthopedic tissue engineering devices as viable clinical solutions demands that the field address significant clinical complications associated with the implantation of foreign materials in the body,especially infection.While tissue engineering has focused on the development of methods to regenerate and repair,until recently there has been a relative dearth of literature regarding the intersection of tissue engineering and infection.In particular,local delivery of antimicrobials has long been of clinical interest,but only recently has that been translated into the realm of tissue engineering.In this perspective,we briefly review major modes of local delivery for infection prevention and treatment and discuss possible strategies for preventing implant-associated infections. | SHAH Sarita R KASPER F Kurtis MIKOS Antonios G | 2013 | Chinese Science Bulletin2013，58，35： | 4 |
| 5 | Evaluating the accuracy of American Society for Gastrointestinal Endoscopy guidelines in patients with acute gallstone pancreatitis with choledocholithiasis显示文摘BACKGROUND Acute gallstone pancreatitis(AGP) is the most common cause of acute pancreatitis(AP) in the United States. Patients with AGP may also present with choledocholithiasis. In 2010, the American Society for Gastrointestinal Endoscopy(ASGE) suggested a management algorithm based on probability for choledocholithiasis, recommending additional imaging for patients at intermediate risk and endoscopic retrograde cholangiopancreatography(ERCP) for patients at high risk of choledocholithiasis. In 2019, the ASGE guidelines were updated using more specific criteria to categorize individuals at high risk for choledocholithiasis. Neither ASGE guideline has been studied in AGP to determine the probability of having choledocholithiasis.AIM To determine compliance with ASGE guidelines, assess outcomes, and compare 2019 vs 2010 ASGE criteria for suspected choledocholithiasis in AGP.METHODS We conducted a retrospective cohort study of 882 patients admitted with AP to a single tertiary care center from 2008-2018. AP was diagnosed using revised Atlanta criteria and AGP was defined as the presence of gallstones on imaging or with cholestatic pattern of liver injury in the absence of another cause. Patients with chronic pancreatitis and pancreatic malignancy were excluded as were those who went directly to cholecystectomy prior to assessment for choledocholithiasis. Patients were assigned low, intermediate or high risk based on ASGE guidelines. Our primary outcomes of interest were the proportion of patients in the intermediate risk group undergoing magnetic resonance cholangiopancreatography(MRCP) first and the proportion of patients in the high risk group undergoing ERCP directly without preceding imaging. Secondary outcomes of interest included outcome differences based on if guidelines were not adhered to. We then evaluated the diagnostic accuracy of 2019 in comparison to the 2010 ASGE criteria for patients with suspected choledocholithiasis. We performed the t test or Wilcoxon rank sum test, as appropriate, to analyze if there were outcome differences based on if guidelines were not adhered to. Kappa coefficients were calculated to measure the degree of agreement between pairs of variables.RESULTS In this cohort, we identified 235 patients with AGP of which 79 patients were excluded as they went directly to surgery for cholecystectomy without prior MRCP or ERCP. Of the remaining 156 patients, 79 patients were categorized as intermediate risk and 77 patients were high risk for choledocholithiasis according to the 2010 ASGE guidelines. Among 79 intermediate risk patients, 54(68%) underwent MRCP first whereas 25 patients(32%) went directly to ERCP. For the 54 patients with intermediate risk who had MRCP first, 36 patients had no choledocholithiasis while 18 patients had evidence of choledocholithiasis prompting ERCP. Of these patients, ERCP confirmed stone disease in 11 patients. Of the 25 intermediate risk patients who directly underwent ERCP, 18 patients had stone disease. One patient with a normal ERCP developed post ERCP pancreatitis. Patients undergoing MRCP in this group had a significantly longer length of stay(5.0 vs 4.0 d, P = 0.02). In the high risk group, 64 patients(83%) had ERCP without preceding imaging, of which, 53 patients had findings consistent with choledocholithiasis, of which 13 patients(17%) underwent MRCP before ERCP, all of which showed evidence of stone disease. Furthermore, all of these patients ultimately had an ERCP, of which 8 patients had evidence of stones and 5 had normal examination.RESULTS Our cohort also demonstrated that 58% of all 156 patients with AGP had confirmed choledocholithiasis(79% of the high risk group and 37% of the intermediate group when risk was assigned based on the 2010 ASGE guidelines). When the updated 2019 ASGE guidelines were applied instead of the original 2010 guidelines, there was moderate agreement between the 2010 and 2019 guidelines(kappa = 0.46, 95%CI: 0.34-0.58). Forty-two of 77 patients were still deemed to be high risk and 35 patients were downgraded to intermediate risk. Thirty-five patients who were originally assigned high risk were reclassified as intermediate risk. For these 35 patients, 26 patients had ERCP findings consistent with choledocholithiasis and 9 patients had a normal examination. Based on the 2019 criteria, 9/35 patients who were downgraded to intermediate risk had an unnecessary ERCP with normal findings(without a preceding MRCP).CONCLUSION Two-thirds in intermediate risk and 83% in high risk group followed ASGE guidelines for choledocholithiasis. One intermediate-group patient with normal ERCP had post-ERCP AP, highlighting the risk of unnecessary procedures. | Supisara Tintara Ishani Shah William Yakah Awais Ahmed Cristina S Sorrento Cinthana Kandasamy Steven D Freedman Darshan J Kothari Sunil G Sheth | 2022 | World Journal of Gastroenterology2022，28，16： | 3 |
| 6 | Spontaneous bacterial peritonitis prevalence in pretransplant patients and its effect on survival and graft loss post-transplant显示文摘AIM To investigate the incidence of spontaneous bacterial peritonitis(SBP) in pre-transplant patients and its effect on post transplant mortality and graft failure. METHODS We conducted a retrospective cohort study of patient records from the organ procurement and transplant network data set. Patients were identified by the presence of SBP pre-transplant. Univariate post-transplant survival models were constructed using the Kaplan-Meier technique and multivariate models were constructed using the Cox proportional hazards model. Variables that affected post-transplant graft survival were identified in the SBP population. RESULTS Forty-seven thousand eight hundred and eighty patient records were included in the analysis for both groups, and 1966(4.11%) patients were identified in the data set as having pre-transplant SBP. Patients that had pre-transplant SBP had higher rates of graft loss from recurrent hepatitis C virus(HCV)(3.6% vs 2.0%, P < 0.0001), infections leading to graft loss(1.9% vs 1.3%, P = 0.02), primary non-function(4.3% vs 3.0%, P < 0.0001) and chronic rejection(1.1% vs 0.7%, P = 0.04). Kaplan-Meier survival analysis showed a statistically significant difference in all-cause survival in patients with a history of SBP vs those without(P < 0.0001). Pretransplant history of SBP was independently predictiveof mortality due to recurrent HCV(HR = 1.11, 95%CI: 1.02-1.21, P < 0.017) after liver transplantation.CONCLUSION HCV patients prior to the advent of directing acting anti-viral agents had a higher incidence of pre-transplant SBP than other patients on the liver transplant wait list. SBP history pre-transplant resulted in a higher rate of graft loss due to recurrent HCV infection and chronic rejection. | Neeral L Shah Nicolas M Intagliata Zachary H Henry Curtis K Argo Patrick G Northup | 2016 | World Journal of Hepatology2016，8，36： | 2 |
| 7 | Effect of cadmium on lipid peroxidation, superoxide anion generation and activities of antioxidant enzymes in growing rice seedlings显示文摘 | Kavita Shah Ritambhara G Kumar Shalini Verma R.S Dubey | 2001 | Plant Science2001，，6： | 2 |
| 8 | Strategic supply chain optimization for the pharmaceutical industries显示文摘 | Lazaros G Papageorgiou Guillermo E Rotstein Nilay Shah | 2001 | Ind Eng Chem Res2001，40，1： | 2 |
| 9 | Anaerobic bioventing of unsaturated zone contaminated wuth DDT and DNT显示文摘 | Shah J K Sayles G D Suidan M T | 2001 | Water Sci Technol2001，43，2： | 2 |
| 10 | Epigenetic pathways and glioblastoma treatment显示文摘 | Jennifer Clarke Clara Penas Chiara Pastori Ricardo J Komotar Amade Bregy Ashish H Shah Claes Wahlestedt Nagi G Ayad | 2013 | Epigenetics2013，，8： | 2 |
| 11 | Microfacies and Depositional Environments of Miocene Isolated Carbonate Platforms from Central Luconia, Offshore Sarawak, Malaysia显示文摘The Luconia Province-offshore Sarawak-is a key geological unit for understanding the distribution of hydrocarbon resources in Malaysia. Nevertheless, little effort has been made to address the palaeoenvironmental characteristics of the Tertiary carbonates in the key sector of Central Luconia.We study the sedimentology and petrography of core samples from a well in Central Luconia, for which thirteen microfacies have been identified reflecting different depositional settings. This is the first microfacies scheme elaborated for Luconian carbonates. Lithofacies and microfacies distribution are compatible with deposition in a reef complex, originating around a framework reef, within the euphotic zone. Sediments were deposited in environments of backreef, reef crest, and forereef. The fair weather wave base is marked by the presence of coralline red algae, foraminifera, decreasing degree of bioclast fragmentation and other microfacies features. As a result, a depositional-environmental model is constructed, depicting a reef complex built around a framework reef developed on the margin of an isolated platform. In addition, an innovative, preliminary time series analysis of facies, microfacies and depositional environment data reveal the existence of seasonal cycles in the stacking patterns of facies and microfacies. | Hammad Tariq JANJUHAH José Antonio GáMEZ VINTANED Ahmed Mohamed Ahmed SALIM Ibrahima FAYE Mumtaz Muhammad SHAH Deva Prasad GHOSH | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 2 |
| 12 | Long - term foUow - up of patients after endo-scopic sphincterotomy for choledocholithiasis, and risk factors recurrence 显示文摘 | Costamagna G Tringali A Shah SK | 2002 | Endoscopy2002，34，4： | 1 |
| 13 | 显示文摘 | Shah Y T Kelkar B G Godbole S P | 1982 | AlChE J1982，28，： | 1 |
| 14 | Therapeutic biliary endoscopy显示文摘 | Shah S K Mutignani M G Costamagna | 2002 | Endoscopy2002，34，： | 1 |
| 15 | Integrated production planning and scheduling optimization of multisite,multiproduct process industry显示文摘 | Shah N K Ierapetritou M G | 2012 | Computers & Chemical Engineering2012，37，10： | 1 |
| 16 | On chip droplet characterization: a practical, high sensitivity measurement of droplet impedance in digital microfluidics显示文摘 | SADEGHI S DING H SHAH G J | 2012 | Analytical chemistry2012，84，4： | 1 |
| 17 | Perceptual voice characteristics in pediatric unilateral vocal fold paralysis显示文摘 | Shah RK Harvey-Woodnorth G Glynn A | 2006 | Oto- laryngol Head Neck Surg2006，134，4： | 1 |
| 18 | A Framework for Integrating Real-Time MRI with Robot Control : Application to Simu- lated Transapieal Cardiac Interventions显示文摘 | Navkar N V Deng Z G Shah D J | 2013 | IEEE Trans on Biomedical Engineering2013，60，4： | 1 |
| 19 | Amino acid biosynthesis in-hibitors as herbicides 显示文摘 | Kishore G M Shah D M | 1988 | Annual Review of Biochem-istry1988，57，62： | 1 |
| 20 | Incremental dia- gnostic and prognostic value of contemporary stress echocardiography in a chest pain unit: mortality and morbidity outcomes from a real-world setting 显示文摘 | Shah BN Balaji G Alhajiri A | 2013 | Cardiovasc Imaging2013，6，2： | 1 |
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